The possible role of myocardial biopsy in systemic sclerosis
The histopathological features of heart involvement in systemic sclerosis (SSc) are not widely known. In internal and transplantation medicine, myocardial biopsies are increasingly used to diagnose cardiomyopathies including myocarditis. In two SSc patients presenting with dyspnoea with no evidence...
Saved in:
Published in | Rheumatology (Oxford, England) Vol. 39; no. 6; pp. 674 - 679 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Oxford University Press
01.06.2000
Oxford Publishing Limited (England) |
Subjects | |
Online Access | Get full text |
ISSN | 1462-0324 1462-0332 |
DOI | 10.1093/rheumatology/39.6.674 |
Cover
Summary: | The histopathological features of heart involvement in systemic sclerosis (SSc) are not widely known. In internal and transplantation medicine, myocardial biopsies are increasingly used to diagnose cardiomyopathies including myocarditis. In two SSc patients presenting with dyspnoea with no evidence of pulmonary involvement, the cause of the compromised heart function was sought by myocardial biopsy. Immunohistological analysis revealed an increased number of CD3+ + T cells indicating myocarditis in one, and increased amounts of fibroblasts in both SSc patients. The authors think that myocardial involvement in SSc should be differentially evaluated and they propose the use of myocardial biopsies as a tool to distinguish between inflammatory and fibrotic forms of heart involvement in SSc patients. |
---|---|
Bibliography: | ark:/67375/HXZ-1W7H5243-K local:0390674 istex:6B3B9BBB229575BB132EB6714FD5EC4E745F034B PII:1460-2172 ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Case Study-2 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 |
ISSN: | 1462-0324 1462-0332 |
DOI: | 10.1093/rheumatology/39.6.674 |