The transition zone: an essential functional compartment of cilia

Recent studies of the primary cilium have begun to provide further insights into ciliary ultrastructure, with an emerging picture of complex compartmentalization and molecular components that combine in functional modules. Many proteins that are mutated in ciliopathies are localized to the transitio...

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Bibliographic Details
Published inCilia (London) Vol. 1; no. 1; p. 10
Main Authors Szymanska, Katarzyna, Johnson, Colin A
Format Journal Article
LanguageEnglish
Published London BioMed Central 02.07.2012
BioMed Central Ltd
Subjects
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cellular proteins
Cilia and ciliary motion
Developmental Biology
Human Genetics
Life Sciences
Molecular Medicine
Physiological aspects
Proteins
Receptors
Review
United Kingdom
Ciliopathies
Transition zone
IFT
Cilia
Online AccessGet full text
ISSN2046-2530
2046-2530
DOI10.1186/2046-2530-1-10

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Summary:Recent studies of the primary cilium have begun to provide further insights into ciliary ultrastructure, with an emerging picture of complex compartmentalization and molecular components that combine in functional modules. Many proteins that are mutated in ciliopathies are localized to the transition zone, a compartment of the proximal region of the cilium. The loss of these components can disrupt ciliary functions such as the control of protein entry and exit from the cilium, the possible trafficking of essential ciliary components, and the regulation of signaling cascades and control of the cell cycle. The discovery of functional modules within the primary cilium may help in understanding the variable phenotypes and pleiotropy in ciliopathies.
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ISSN:2046-2530
2046-2530
DOI:10.1186/2046-2530-1-10