Long-Term Complications in Youth-Onset Type 2 Diabetes

• Published in: The New England journal of medicine Vol. 385; no. 5; pp. 416 - 426
• Main Authors: Bjornstad, Petter, Drews, Kimberly L, Caprio, Sonia, Gubitosi-Klug, Rose, Nathan, David M, Tesfaldet, Bereket, Tryggestad, Jeanie, White, Neil H, Zeitler, Philip
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 29.07.2021
• Subjects: Adolescence; Adolescent; Adolescent Medicine; Adverse events; Age; Algorithms; Antidiabetics; Blood pressure; Cardiology; Cardiology General; Child; Childhood Diseases; Chronic Kidney Disease; Clinical trials; Diabetes; Diabetes Complications - epidemiology; Diabetes Complications - ethnology; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Diabetic neuropathy; Diabetic retinopathy; Dyslipidemia; Dyslipidemias - complications; Dyslipidemias - epidemiology; Endocrinology; Eye diseases; Fasting; Female; Follow-Up Studies; Growth and Development; Humans; Hyperglycemia; Hypertension; Hypertension - complications; Hypertension - epidemiology; Hypoglycemic Agents - therapeutic use; Insulin; Insulin resistance; Kidney diseases; Laboratories; Lipids; Male; Metabolic disorders; Metformin; Metformin - therapeutic use; Microvasculature; Minority & ethnic groups; Nephrology; Ophthalmology; Ophthalmology General; Pediatrics; Pediatrics General; Retina; Risk Factors; Rosiglitazone; Teenagers; United States > US
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMoa2100165

A clinical trial assessed the efficacy of three treatments, all involving metformin, on glycemic control in youth-onset type 2 diabetes. This follow-up study shows that the risk of complications increased steadily over time, and complications developed in most participants by young adulthood.