Amino Acids and Peptides. XXI. : Synthesis of N-Terminal Heptapeptide of Mammalian Metallothionein (MT) and Evaluation of Its Immunoreactivity

The common N-terminal heptapeptide, Ac-Met-Asp-Pro-Asn-Cys-Ser-Cys-OH, Ac-(MT II 1-7)-OH, of mammalian metallothioneins (MTs) was synthesised by a conventional solution method using newly developed β-2-adamantylasparate. This peptide was as reactive as native MT with a monoclonal antibody produced a...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 36; no. 9; pp. 3614 - 3618
Main Authors IGUCHI, SHIN, TERAO, TADAO, KIKUCHI, YUTAKA, IKEBUCHI, HIDEHARU, SAWADA, JUN-ICHI, IRIE, MASACHIKA, OKADA, YOSHIO, NAKAYAMA, SHIGERU
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 1988
公益社団法人日本薬学会
Maruzen
Subjects
Chemical Phenomena
chemical synthesis
Chemistry
common sequence
crossreactivity
Exact sciences and technology
mammalian metallothionein
Metallothionein - chemical synthesis
Metallothionein - immunology
metallothioneins
monoclonal antibody
N-terminal heptapeptide
Oligopeptides - chemical synthesis
Oligopeptides - immunology
Organic chemistry
peptide synthesis
Peptides
Preparations and properties
Radioimmunoassay
rat zinc-metallothionein II
rats
β-adamantylaspartate
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ISSN0009-2363
1347-5223
1347-5223
DOI10.1248/cpb.36.3614

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Summary:The common N-terminal heptapeptide, Ac-Met-Asp-Pro-Asn-Cys-Ser-Cys-OH, Ac-(MT II 1-7)-OH, of mammalian metallothioneins (MTs) was synthesised by a conventional solution method using newly developed β-2-adamantylasparate. This peptide was as reactive as native MT with a monoclonal antibody produced against rat Zn-MT II.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0009-2363
1347-5223
1347-5223
DOI:10.1248/cpb.36.3614