Determinants of surgical repair of patent ductus arteriosus in low-birth-weight infants
Purpose To identify risk factors related to the failure of indomethacin therapy and the need for surgical repair in patent ductus arteriosus (PDA) in extremely low-birth-weight (<1000 g) infants (ELBWI). Methods Study subjects were 36 ELBWI with PDA born at a single tertiary perinatal center. The...
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Published in | Journal of medical ultrasonics (2001) Vol. 38; no. 3; pp. 151 - 155 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Japan
Springer Japan
01.07.2011
Springer Springer Nature B.V |
Subjects | |
Online Access | Get full text |
ISSN | 1346-4523 1613-2254 |
DOI | 10.1007/s10396-011-0309-8 |
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Summary: | Purpose
To identify risk factors related to the failure of indomethacin therapy and the need for surgical repair in patent ductus arteriosus (PDA) in extremely low-birth-weight (<1000 g) infants (ELBWI).
Methods
Study subjects were 36 ELBWI with PDA born at a single tertiary perinatal center. They were classified into those who required surgery due to failure of indomethacin treatment (surgical group,
n
= 21) and those with effective indomethacin treatment (non-surgical group,
n
= 15). The odds ratios (ORs) and 95% confidence intervals (95% CIs) for the relationship between selected risk factors and surgical treatment of PDA were calculated.
Results
Gestational age of <28 weeks and diameter of PDA of 2 mm or more were independent and significant determinants of the need for surgical repair of PDA (adjusted ORs [95% CIs] = 9.91 [1.16–84.48] and 24.80 [2.72–225.74], respectively). The need for surgical repair of PDA did not correlate with sex, birth weight, 1-min Apgar score, left atrium diameter/aortic diameter (LA/Ao), left ventricular internal dimension at end-diastole, prophylaxes with indomethacin, and total dosage of indomethacin.
Conclusions
Gestational age at birth of <28 weeks and diameter of PDA of 2 mm or more are determinants of failure of indomethacin treatment for PDA and the need for surgical repair. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
ISSN: | 1346-4523 1613-2254 |
DOI: | 10.1007/s10396-011-0309-8 |