Determinants of surgical repair of patent ductus arteriosus in low-birth-weight infants

Purpose To identify risk factors related to the failure of indomethacin therapy and the need for surgical repair in patent ductus arteriosus (PDA) in extremely low-birth-weight (<1000 g) infants (ELBWI). Methods Study subjects were 36 ELBWI with PDA born at a single tertiary perinatal center. The...

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Published inJournal of medical ultrasonics (2001) Vol. 38; no. 3; pp. 151 - 155
Main Authors Yoshikane, Yukako, Mori, Toshiko, Yoshizato, Toshiyuki, Miyake, Yoshihiro, Hirose, Shinichi
Format Journal Article
LanguageEnglish
Published Japan Springer Japan 01.07.2011
Springer
Springer Nature B.V
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ISSN1346-4523
1613-2254
DOI10.1007/s10396-011-0309-8

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Summary:Purpose To identify risk factors related to the failure of indomethacin therapy and the need for surgical repair in patent ductus arteriosus (PDA) in extremely low-birth-weight (<1000 g) infants (ELBWI). Methods Study subjects were 36 ELBWI with PDA born at a single tertiary perinatal center. They were classified into those who required surgery due to failure of indomethacin treatment (surgical group, n  = 21) and those with effective indomethacin treatment (non-surgical group, n  = 15). The odds ratios (ORs) and 95% confidence intervals (95% CIs) for the relationship between selected risk factors and surgical treatment of PDA were calculated. Results Gestational age of <28 weeks and diameter of PDA of 2 mm or more were independent and significant determinants of the need for surgical repair of PDA (adjusted ORs [95% CIs] = 9.91 [1.16–84.48] and 24.80 [2.72–225.74], respectively). The need for surgical repair of PDA did not correlate with sex, birth weight, 1-min Apgar score, left atrium diameter/aortic diameter (LA/Ao), left ventricular internal dimension at end-diastole, prophylaxes with indomethacin, and total dosage of indomethacin. Conclusions Gestational age at birth of <28 weeks and diameter of PDA of 2 mm or more are determinants of failure of indomethacin treatment for PDA and the need for surgical repair.
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ISSN:1346-4523
1613-2254
DOI:10.1007/s10396-011-0309-8