Recent Developments in the Synthesis of Five- and Six-Membered Heterocycles Using Molecular Iodine

• Published in: Chemistry : a European journal Vol. 18; no. 18; pp. 5460 - 5489
• Main Authors: Parvatkar, Prakash T., Parameswaran, Perunninakulath S., Tilve, Santosh G.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 27.04.2012; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Catalysis; Chemistry; Chemistry Techniques, Synthetic - methods; Formations; Functional groups; heterocycles; Heterocyclic compounds; Heterocyclic Compounds - chemical synthesis; Heterocyclic Compounds - chemistry; Iodine; Iodine - chemistry; Low cost; multicomponent reactions; Scaffolds; Synthesis; Synthesis (chemistry); synthetic methods
• ISSN: 0947-6539; 1521-3765; 1521-3765
• DOI: 10.1002/chem.201100324

Heterocyclic scaffolds represent the key structural subunits of many biologically active compounds. Over the last few years iodine‐mediated reactions have been extensively studied due to their low cost and eco‐friendliness. This Review covers advances in the field of iodine‐mediated synthesis of heterocyclic compounds since 2006, especially with an emphasis on mechanisms of ring formation. In this article, syntheses of different heterocycles are classified based on the manipulation of functional groups. Eco‐friendly iodine: Heterocyclic scaffolds represent the key structural subunits of many biologically active compounds. Over the last few years iodine‐mediated reactions have been extensively studied due to their low cost and eco‐friendliness. This Review covers advances in the field of iodine‐mediated synthesis of heterocyclic compounds since 2006, especially with an emphasis on mechanisms of ring formation.