Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain

Subjects with Alzheimer's disease (AD) have elevated brain levels of the selenium transporter selenoprotein P (Sepp1). We investigated if this elevation results from increased release of Sepp1 from the choroid plexus (CP). Sepp1 is significantly increased in CP from AD brains in comparison to n...

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Published inJournal of Alzheimer's disease Vol. 44; no. 2; p. 379
Main Authors Rueli, Rachel H L H, Parubrub, Arlene C, Dewing, Andrea S T, Hashimoto, Ann C, Bellinger, Miyoko T, Weeber, Edwin J, Uyehara-Lock, Jane H, White, Lon R, Berry, Marla J, Bellinger, Frederick P
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2015
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ISSN1875-8908
DOI10.3233/JAD-141755

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Abstract Subjects with Alzheimer's disease (AD) have elevated brain levels of the selenium transporter selenoprotein P (Sepp1). We investigated if this elevation results from increased release of Sepp1 from the choroid plexus (CP). Sepp1 is significantly increased in CP from AD brains in comparison to non-AD brains. Sepp1 localizes to the trans-Golgi network within CP epithelia, where it is processed for secretion. The cerebrospinal fluid from AD subjects also contains increased levels Sepp1 in comparison to non-AD subjects. These findings suggest that AD pathology induces increased levels of Sepp1 within CP epithelia for release into the cerebrospinal fluid to ultimately increase brain selenium.
AbstractList Subjects with Alzheimer's disease (AD) have elevated brain levels of the selenium transporter selenoprotein P (Sepp1). We investigated if this elevation results from increased release of Sepp1 from the choroid plexus (CP). Sepp1 is significantly increased in CP from AD brains in comparison to non-AD brains. Sepp1 localizes to the trans-Golgi network within CP epithelia, where it is processed for secretion. The cerebrospinal fluid from AD subjects also contains increased levels Sepp1 in comparison to non-AD subjects. These findings suggest that AD pathology induces increased levels of Sepp1 within CP epithelia for release into the cerebrospinal fluid to ultimately increase brain selenium.
Author White, Lon R
Parubrub, Arlene C
Dewing, Andrea S T
Berry, Marla J
Bellinger, Miyoko T
Weeber, Edwin J
Bellinger, Frederick P
Hashimoto, Ann C
Rueli, Rachel H L H
Uyehara-Lock, Jane H
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Issue 2
Keywords selenium
cerebrospinal fluid
selenoproteins
Alzheimer's disease
Sepp1
choroid plexus
selenoprotein P
Language English
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PublicationTitle Journal of Alzheimer's disease
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Snippet Subjects with Alzheimer's disease (AD) have elevated brain levels of the selenium transporter selenoprotein P (Sepp1). We investigated if this elevation...
SourceID pubmed
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StartPage 379
SubjectTerms Aged, 80 and over
Alzheimer Disease - metabolism
Blotting, Western
Brain - metabolism
Choroid Plexus - metabolism
Humans
Immunohistochemistry
Male
Selenoprotein P - metabolism
Title Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain
URI https://www.ncbi.nlm.nih.gov/pubmed/25298198
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