Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain
Subjects with Alzheimer's disease (AD) have elevated brain levels of the selenium transporter selenoprotein P (Sepp1). We investigated if this elevation results from increased release of Sepp1 from the choroid plexus (CP). Sepp1 is significantly increased in CP from AD brains in comparison to n...
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Published in | Journal of Alzheimer's disease Vol. 44; no. 2; p. 379 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
01.01.2015
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Subjects | |
Online Access | Get more information |
ISSN | 1875-8908 |
DOI | 10.3233/JAD-141755 |
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Abstract | Subjects with Alzheimer's disease (AD) have elevated brain levels of the selenium transporter selenoprotein P (Sepp1). We investigated if this elevation results from increased release of Sepp1 from the choroid plexus (CP). Sepp1 is significantly increased in CP from AD brains in comparison to non-AD brains. Sepp1 localizes to the trans-Golgi network within CP epithelia, where it is processed for secretion. The cerebrospinal fluid from AD subjects also contains increased levels Sepp1 in comparison to non-AD subjects. These findings suggest that AD pathology induces increased levels of Sepp1 within CP epithelia for release into the cerebrospinal fluid to ultimately increase brain selenium. |
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AbstractList | Subjects with Alzheimer's disease (AD) have elevated brain levels of the selenium transporter selenoprotein P (Sepp1). We investigated if this elevation results from increased release of Sepp1 from the choroid plexus (CP). Sepp1 is significantly increased in CP from AD brains in comparison to non-AD brains. Sepp1 localizes to the trans-Golgi network within CP epithelia, where it is processed for secretion. The cerebrospinal fluid from AD subjects also contains increased levels Sepp1 in comparison to non-AD subjects. These findings suggest that AD pathology induces increased levels of Sepp1 within CP epithelia for release into the cerebrospinal fluid to ultimately increase brain selenium. |
Author | White, Lon R Parubrub, Arlene C Dewing, Andrea S T Berry, Marla J Bellinger, Miyoko T Weeber, Edwin J Bellinger, Frederick P Hashimoto, Ann C Rueli, Rachel H L H Uyehara-Lock, Jane H |
Author_xml | – sequence: 1 givenname: Rachel H L H surname: Rueli fullname: Rueli, Rachel H L H organization: Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA – sequence: 2 givenname: Arlene C surname: Parubrub fullname: Parubrub, Arlene C organization: Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA – sequence: 3 givenname: Andrea S T surname: Dewing fullname: Dewing, Andrea S T organization: Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA – sequence: 4 givenname: Ann C surname: Hashimoto fullname: Hashimoto, Ann C organization: Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA – sequence: 5 givenname: Miyoko T surname: Bellinger fullname: Bellinger, Miyoko T organization: Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA – sequence: 6 givenname: Edwin J surname: Weeber fullname: Weeber, Edwin J organization: Molecular Pharmacology and Physiology, University of South Florida, Johnnie B. Byrd, Sr. Alzheimer's Center & Research Institute, Tampa, FL, USA – sequence: 7 givenname: Jane H surname: Uyehara-Lock fullname: Uyehara-Lock, Jane H organization: Pathology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA – sequence: 8 givenname: Lon R surname: White fullname: White, Lon R organization: Pacific Health Research and Education Institute, Honolulu, HI, USA – sequence: 9 givenname: Marla J surname: Berry fullname: Berry, Marla J organization: Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA – sequence: 10 givenname: Frederick P surname: Bellinger fullname: Bellinger, Frederick P organization: Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA |
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Keywords | selenium cerebrospinal fluid selenoproteins Alzheimer's disease Sepp1 choroid plexus selenoprotein P |
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SubjectTerms | Aged, 80 and over Alzheimer Disease - metabolism Blotting, Western Brain - metabolism Choroid Plexus - metabolism Humans Immunohistochemistry Male Selenoprotein P - metabolism |
Title | Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain |
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