Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain

• Published in: Journal of Alzheimer's disease Vol. 44; no. 2; p. 379
• Main Authors: Rueli, Rachel H L H, Parubrub, Arlene C, Dewing, Andrea S T, Hashimoto, Ann C, Bellinger, Miyoko T, Weeber, Edwin J, Uyehara-Lock, Jane H, White, Lon R, Berry, Marla J, Bellinger, Frederick P
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2015
• Subjects: Aged, 80 and over; Alzheimer Disease - metabolism; Blotting, Western; Brain - metabolism; Choroid Plexus - metabolism; Humans; Immunohistochemistry; Male; Selenoprotein P - metabolism; selenium; cerebrospinal fluid; selenoproteins; Alzheimer's disease; Sepp1; choroid plexus; selenoprotein P
• ISSN: 1875-8908
• DOI: 10.3233/JAD-141755

Subjects with Alzheimer's disease (AD) have elevated brain levels of the selenium transporter selenoprotein P (Sepp1). We investigated if this elevation results from increased release of Sepp1 from the choroid plexus (CP). Sepp1 is significantly increased in CP from AD brains in comparison to non-AD brains. Sepp1 localizes to the trans-Golgi network within CP epithelia, where it is processed for secretion. The cerebrospinal fluid from AD subjects also contains increased levels Sepp1 in comparison to non-AD subjects. These findings suggest that AD pathology induces increased levels of Sepp1 within CP epithelia for release into the cerebrospinal fluid to ultimately increase brain selenium.