Diabetes mellitus related bone metabolism and periodontal disease

• Published in: International journal of oral science Vol. 7; no. 2; pp. 63 - 72
• Main Authors: Wu, Ying-Ying, Xiao, E, Graves, Dana T
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2015; Springer Nature B.V; State Key Laboratory of 0ral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China%School of Dental Medicine, University of Pennsylvania, Philadelphia, USA; Nature Publishing Group
• Subjects: Bone Diseases - complications; Bone Diseases - metabolism; Dentistry; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - metabolism; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - metabolism; Humans; Medicine; Oral and Maxillofacial Surgery; Orthopedics; Periodontal Diseases - complications; Review; Surgical Orthopedics; 代谢变化; 危险因素; 慢性疾病; 成骨细胞; 牙周病; 破骨细胞; 糖尿病; 骨代谢; hyperglycemia; osseous; inflammation; periodontitis; diabetes mellitus; osteoblast; osteoclast; bone loss
• ISSN: 1674-2818; 2049-3169
• DOI: 10.1038/ijos.2015.2

Diabetes mellitus and periodontal disease are chronic diseases affecting a large number of populations worldwide.Changed bone metabolism is one of the important long-term complications associated with diabetes mellitus.Alveolar bone loss is one of the main outcomes of periodontitis,and diabetes is among the primary risk factors for periodontal disease.In this review,we summarise the adverse effects of diabetes on the periodontium in periodontitis subjects,focusing on alveolar bone loss.Bone remodelling begins with osteoclasts resorbing bone,followed by new bone formation by osteoblasts in the resorption lacunae.Therefore,we discuss the potential mechanism of diabetes-enhanced bone loss in relation to osteoblasts and osteoclasts.