Long‐term outcomes of status epilepticus: A critical assessment

• Published in: Epilepsia (Copenhagen) Vol. 59; no. S2; pp. 155 - 169
• Main Authors: Sculier, Claudine, Gaínza‐Lein, Marina, Sánchez Fernández, Iván, Loddenkemper, Tobias
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.10.2018; John Wiley and Sons Inc
• Subjects: Adult; Age Factors; Child; Child, Preschool; Children; Cognition Disorders - etiology; Cognitive ability; cognitive outcome; Databases, Factual - statistics & numerical data; Epilepsy; Etiology; Female; functional impairment; Humans; Intensive Care Units - statistics & numerical data; Longitudinal Studies; Male; mortality; neurological sequelae; Patient Acceptance of Health Care - statistics & numerical data; Population studies; Quality of Life; Status Epilepticus - complications; Status Epilepticus - etiology; Status Epilepticus - psychology; Status Epilepticus - therapy; Supplement; Treatment Outcome; epilepsy; mortality; neurological sequelae; quality of life; cognitive outcome; functional impairment
• ISSN: 0013-9580; 1528-1167; 1528-1157; 1528-1167
• DOI: 10.1111/epi.14515

Summary We reviewed 37 studies reporting long‐term outcomes after a status epilepticus (SE) episode in pediatric and adult populations. Study design, length of follow‐up, outcome measures, domains investigated (mortality, SE recurrence, subsequent epilepsy, cognitive outcome, functional outcome, or quality of life), and predictors of long‐term outcomes are summarized. Despite heterogeneity in the design of prior studies, overall risk of poor long‐term outcome after SE is high in both children and adults. Etiology is the main determinant of outcome, and the effect of age or SE duration is often difficult to distinguish from the underlying cause. The effect of the treatment on long‐term outcome after SE is still unknown.