Polygenic risk scores predict diabetes complications and their response to intensive blood pressure and glucose control

• Published in: Diabetologia Vol. 64; no. 9; pp. 2012 - 2025
• Main Authors: Tremblay, Johanne, Haloui, Mounsif, Attaoua, Redha, Tahir, Ramzan, Hishmih, Camil, Harvey, François, Marois-Blanchet, François-Christophe, Long, Carole, Simon, Paul, Santucci, Lara, Hizel, Candan, Chalmers, John, Marre, Michel, Harrap, Stephen, Cífková, Renata, Krajčoviechová, Alena, Matthews, David R., Williams, Bryan, Poulter, Neil, Zoungas, Sophia, Colagiuri, Stephen, Mancia, Giuseppe, Grobbee, Diederick E., Rodgers, Anthony, Liu, Liusheng, Agbessi, Mawussé, Bruat, Vanessa, Favé, Marie-Julie, Harwood, Michelle P., Awadalla, Philip, Woodward, Mark, Hussin, Julie G., Hamet, Pavel
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2021; Springer Nature B.V; Springer Verlag
• Subjects: Age groups; Blood Glucose; Blood pressure; Blood Pressure - genetics; Cardiovascular diseases; Cardiovascular system; Death; Diabetes; Diabetes Complications - complications; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - genetics; Ethnicity; Gender; Genetics; Genome-Wide Association Study; Genomes; Glucose; Health risks; Human Physiology; Humans; Internal Medicine; Life Sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Mortality; Multifactorial Inheritance; Risk Factors; Risk groups; Single-nucleotide polymorphism; ADVANCE trial; Polygenic risk score; Renal complications; Prediction; Genetics; UK Biobank; Cardiovascular complications
• ISSN: 0012-186X; 1432-0428; 1432-0428
• DOI: 10.1007/s00125-021-05491-7

Aims/hypothesis Type 2 diabetes increases the risk of cardiovascular and renal complications, but early risk prediction could lead to timely intervention and better outcomes. Genetic information can be used to enable early detection of risk. Methods We developed a multi-polygenic risk score (multiPRS) that combines ten weighted PRSs (10 wPRS) composed of 598 SNPs associated with main risk factors and outcomes of type 2 diabetes, derived from summary statistics data of genome-wide association studies. The 10 wPRS, first principal component of ethnicity, sex, age at onset and diabetes duration were included into one logistic regression model to predict micro- and macrovascular outcomes in 4098 participants in the ADVANCE study and 17,604 individuals with type 2 diabetes in the UK Biobank study. Results The model showed a similar predictive performance for cardiovascular and renal complications in different cohorts. It identified the top 30% of ADVANCE participants with a mean of 3.1-fold increased risk of major micro- and macrovascular events ( p  = 6.3 × 10 −21 and p  = 9.6 × 10 −31 , respectively) and a 4.4-fold ( p  = 6.8 × 10 −33 ) higher risk of cardiovascular death. While in ADVANCE overall, combined intensive blood pressure and glucose control decreased cardiovascular death by 24%, the model identified a high-risk group in whom it decreased the mortality rate by 47%, and a low-risk group in whom it had no discernible effect. High-risk individuals had the greatest absolute risk reduction with a number needed to treat of 12 to prevent one cardiovascular death over 5 years. Conclusions/interpretation This novel multiPRS model stratified individuals with type 2 diabetes according to risk of complications and helped to target earlier those who would receive greater benefit from intensive therapy. Graphical abstract