Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1

• Published in: Journal of applied physiology (1985) Vol. 94; no. 1; pp. 179 - 184
• Main Authors: Ohga, Eijiro, Tomita, Tetsuji, Wada, Hiroo, Yamamoto, Hiroshi, Nagase, Takahide, Ouchi, Yasuyoshi
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01.01.2003; American Physiological Society
• Subjects: Anatomy & physiology; Biological and medical sciences; Cardiovascular disease; Chemokine CCL2 - blood; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes; Humans; Hypoxia; Hypoxia - blood; Hypoxia - etiology; Intercellular Adhesion Molecule-1 - blood; Interleukin-8 - blood; Male; Medical sciences; Middle Aged; Nervous system (semeiology, syndromes); Neurology; Positive-Pressure Respiration; Risk factors; Sleep; Sleep Apnea, Obstructive - blood; Sleep Apnea, Obstructive - complications; Sleep Apnea, Obstructive - therapy; Stress, Physiological - blood; Stress, Physiological - etiology; Human; Sleep apnea syndrome; Intercellular adhesion molecule 1; cardiovascular disorders; intracellular adhesion molecule-1; Sleep disorder; ischemic heart disease; monocyte chemoattractant protein-1; Cardiovascular disease; hypoxic stress; interleukin-8; Coronary heart disease; Obstruction; desaturation magnitude; Stress; Risk factor; Hypoxia; cytokines; Interleukin 8; Monocyte chemoattractant protein 1
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/japplphysiol.00177.2002

Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Tokyo1 13-8655, Japan Obstructive sleep apnea syndrome (OSAS) is one of the most important risk factors of cardiovascular disorders. In the treatment of OSAS, nasal continuous positive airway pressure (nCPAP) has been widely used and found to be effective. In the present study, we hypothesized that the hypoxic stress caused by obstructive sleep apnea would increase circulating intercellular adhesion molecule-1 (ICAM-1), interleukin-8 (IL-8), and monocyte chemoattractant protein-1 (MCP-1) in untreated OSAS patients compared with an age-matched control group. In addition, we hypothesized that nCPAP may decrease OSAS-induced hypoxic stress and mediators. To examine these hypotheses, we measured circulating ICAM-1 and IL-8 before and after nCPAP therapy in OSAS patients. We observed that nCPAP decreased apnea, desaturation, and the circulating ICAM-1 and IL-8 levels in OSAS patients. The circulating levels of ICAM-1, IL-8, and MCP-1 in untreated OSAS patients were significantly greater than those in the controls. These observations suggest that nCPAP therapy could reduce OSAS-induced hypoxia and generation of inflammatory mediators. Treatment of OSAS using nCPAP can be, therefore, a potential approach to decrease risk of the progression of OSAS-associated disorders. cytokines; cardiovascular disorders; ischemic heart disease; desaturation magnitude; hypoxic stress; intracellular adhesion molecule-1; monocyte chemoattractant protein-1; interleukin-8