Metabolic profile of first and second generation antipsychotics among Chinese patients

• Published in: Psychiatry research Vol. 185; no. 3; pp. 456 - 458
• Main Authors: Lee, Edwin, Chow, Lai-Yin, Leung, Chi-Ming
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ireland Ltd 28.02.2011; Elsevier
• Subjects: Adult; Antipsychotic Agents - classification; Antipsychotic Agents - metabolism; Antipsychotic Agents - therapeutic use; Asian Continental Ancestry Group; Biological and medical sciences; Body Mass Index; Chlorpromazine; Cholesterol - metabolism; Dyslipidemia; Female; Haloperidol; Humans; Male; Medical sciences; Mental Disorders - drug therapy; Mental Disorders - metabolism; Middle Aged; Neuropharmacology; Olanzapine; Pharmacology. Drug treatments; Psychiatry; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Risperidone; Trifluoperazine; Ziprasidone; Olanzapine; Trifluoperazine; Ziprasidone; Dyslipidemia; Haloperidol; Risperidone; Chlorpromazine; Dibenzodiazepine derivatives; Atypical antipsychotic; Neuroleptic; Psychotropic; Lipids; Phenothiazine derivatives; Serotonine receptor; Dyslipemia; Benzisoxazole derivatives; Human; Dopamine antagonist; Serotonin antagonist; Metabolic diseases; Butyrophenone derivatives; Thienobenzodiazepine derivatives; 5-HT2 Serotonine receptor; D2 Dopamine receptor; Chinese; Piperazine derivatives
• ISSN: 0165-1781; 1872-7123
• DOI: 10.1016/j.psychres.2010.04.050

The metabolic profiles of Chinese patients treated with second-generation antipsychotic (SGA) medication and first-generation antipsychotic (FGA) medication were compared. The sample comprised 99 patients treated with SGA (risperidone, olanzapine and ziprasidone) and 99 with FGA (chlorpromazine, haloperidol and trifluoperazine) from the outpatient clinic of a teaching hospital in Hong Kong. The most frequent psychiatric diagnosis was schizophrenia, followed by affective disorder and other psychiatric diagnoses. Subjects were measured for body weight, body height, fasting lipid and glucose levels. SGA was associated with higher LDL-cholesterol level than FGA. Individual comparison of different antipsychotics showed that patients on olanzapine had the greatest increases in cholesterol and triglycerides among all antipsychotics. The finding suggested SGA, particularly olanzapine, were associated with more metabolic risk factors than first-generation antipsychotics.