Modifications of quinolones and fluoroquinolones: hybrid compounds and dual-action molecules

• Published in: Monatshefte für Chemie Vol. 149; no. 7; pp. 1199 - 1245
• Main Authors: Fedorowicz, Joanna, Sączewski, Jarosław
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.01.2018; Springer Nature B.V
• Subjects: Analytical Chemistry; Chemical compounds; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Coordination compounds; Drugs; Fluorescence; Inorganic Chemistry; Lipophilicity; Literature reviews; Molecular chains; Nanoparticles; Organic Chemistry; Peptides; Pharmacology; Phosphonates; Physical Chemistry; Proteins; Review; Theoretical and Computational Chemistry; Triazoles; Conjugates; Antitumor agents; Antibiotics; Drug research; Hybrid drugs; Antiviral activity
• ISSN: 0026-9247; 1434-4475
• DOI: 10.1007/s00706-018-2215-x

This review is aimed to provide extensive survey of quinolones and fluoroquinolones for a variety of applications ranging from metal complexes and nanoparticle development to hybrid conjugates with therapeutic uses. The review covers the literature from the past 10 years with emphasis placed on new applications and mechanisms of pharmacological action of quinolone derivatives. The following are considered: metal complexes, nanoparticles and nanodrugs, polymers, proteins and peptides, NO donors and analogs, anionic compounds, siderophores, phosphonates, and prodrugs with enhanced lipophilicity, phototherapeutics, fluorescent compounds, triazoles, hybrid drugs, bis-quinolones, and other modifications. This review provides a comprehensive resource, summarizing a broad range of important quinolone applications with great utility as a resource concerning both chemical modifications and also novel hybrid bifunctional therapeutic agents. Graphical abstract