Monocyte Subpopulations in Angiogenesis

• Published in: Cancer research (Chicago, Ill.) Vol. 74; no. 5; pp. 1287 - 1293
• Main Authors: Dalton, Heather J., Armaiz-Pena, Guillermo N., Gonzalez-Villasana, Vianey, Lopez-Berestein, Gabriel, Bar-Eli, Menashe, Sood, Anil K.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.03.2014
• Subjects: Animals; Antineoplastic agents; Biological and medical sciences; Humans; Medical sciences; Monocytes - pathology; Neoplasms - blood supply; Neoplasms - pathology; Neovascularization, Pathologic - pathology; Pharmacology. Drug treatments; Tumor Microenvironment - physiology; Tumors; Angiogenesis; Neovascularization; Monocyte; Cell subpopulation
• ISSN: 0008-5472; 1538-7445; 1538-7445
• DOI: 10.1158/0008-5472.CAN-13-2825

Growing understanding of the role of the tumor microenvironment in angiogenesis has brought monocyte-derived cells into focus. Monocyte subpopulations are an increasingly attractive therapeutic target in many pathologic states, including cancer. Before monocyte-directed therapies can be fully harnessed for clinical use, understanding of monocyte-driven angiogenesis in tissue development and homeostasis, as well as malignancy, is required. Here, we provide an overview of the mechanisms by which monocytic subpopulations contribute to angiogenesis in tissue and tumor development, highlight gaps in our existing knowledge, and discuss opportunities to exploit these cells for clinical benefit. Cancer Res; 74(5); 1287–93. ©2014 AACR.