Platelet serotonin uptake in drug-naïve depressive patients before and after treatment with citalopram
We investigated the kinetic parameters of serotonin (5-HT) uptake into platelets in a group of 26 drug-naïve patients suffering from major depression before and after 3–7 weeks of treatment with citalopram. The degree of depression was rated using the Hamilton Depression Rating Scale (HDRS). The 5-H...
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Published in | Psychiatry research Vol. 161; no. 2; pp. 185 - 194 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Kidlington
Elsevier Ireland Ltd
30.11.2008
Elsevier |
Subjects | |
Online Access | Get full text |
ISSN | 0165-1781 1872-7123 |
DOI | 10.1016/j.psychres.2007.06.022 |
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Summary: | We investigated the kinetic parameters of serotonin (5-HT) uptake into platelets in a group of 26 drug-naïve patients suffering from major depression before and after 3–7 weeks of treatment with citalopram. The degree of depression was rated using the Hamilton Depression Rating Scale (HDRS). The 5-HT uptake characteristics in untreated depressive patients were not significantly different from those of normal subjects. The apparent Michaelis constant (
K
M) was significantly increased, the apparent maximal velocity (
V
max) was not different from baseline, and the uptake efficiency (
V
max
/
K
M) was significantly decreased after citalopram treatment. A significantly positive correlation between
K
M and
V
max was found in all groups. There was a significantly lower
V
max and
V
max
/
K
M in the female compared with the male depressed patients before citalopram treatment; a hypothesis was supported that lowered 5-HT uptake may reflect a gender-linked vulnerability to a serotonin-related depression. A significant negative correlation between 5-HT uptake efficiency and the initial HDRS score suggests that platelet 5-HT uptake can be used as a marker of effective depressive disorder pharmacotherapy. The initial severity of depression was significantly negatively correlated with
V
max, which supported a hypothesis that the initial severity of depressive disorder could be related to the lower
V
max. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0165-1781 1872-7123 |
DOI: | 10.1016/j.psychres.2007.06.022 |