Association of the anti-angiogenic factor secreted protein and rich in cysteine (SPARC) with vascular complications among Chinese type 2 diabetic patients in Singapore

• Published in: Journal of diabetes and its complications Vol. 31; no. 7; pp. 1222 - 1227
• Main Authors: Moh, Mei Chung, Sum, Chee Fang, Tavintharan, Subramaniam, Pek, Sharon Li Ting, Yeoh, Lee Ying, Ng, Xiaowei, Lee, Simon Biing Ming, Tang, Wern Ee, Lim, Su Chi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2017; Elsevier Limited
• Subjects: Aged; Angiogenesis; Ankle Brachial Index; Aortic Diseases - blood; Aortic Diseases - complications; Aortic Diseases - ethnology; Aortic stiffness; Asian Continental Ancestry Group; Biomarkers - blood; Biopsy; Cardiovascular disease; Chronic kidney disease; Cohort Studies; Cross-Sectional Studies; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - ethnology; Diabetic Angiopathies - blood; Diabetic Angiopathies - ethnology; Diabetic retinopathy; Down-Regulation; Endocrinology; Endocrinology & Metabolism; Family medical history; Female; Gastric cancer; Glycoproteins; Humans; Immunoassay; Insulin resistance; Kidney diseases; Male; Middle Aged; Obesity; Osteonectin - blood; Peripheral arterial disease; Peripheral Arterial Disease - blood; Peripheral Arterial Disease - complications; Peripheral Arterial Disease - ethnology; Primary Health Care; Proteins; Pulse Wave Analysis; Reproducibility of Results; Singapore; SPARC; Type 2 diabetes; Up-Regulation; Vascular endothelial growth factor; Vascular Stiffness; Singapore; Type 2 diabetes; Peripheral arterial disease; Angiogenesis; Chronic kidney disease; SPARC; Aortic stiffness
• ISSN: 1056-8727; 1873-460X; 1873-460X
• DOI: 10.1016/j.jdiacomp.2016.03.029

This study evaluated the association of the anti-angiogenic SPARC with known angiogenesis-associated factors and diabetes-related micro- and macro-vascular complications in a Singapore Chinese cohort with type 2 diabetes (T2DM). Plasma SPARC was measured by immunoassay in 438 T2DM adults (mean age:58±11years). Higher SPARC levels in subjects stratified by SPARC tertiles displayed decreased pro-angiogenic adiponectin, osteopontin, vascular cell adhesion molecule (VCAM)-1 and matrix metalloproteinase (MMP)-2 concentrations (all p<0.05). The anti-angiogenic pigment epithelium-derived factor (PEDF) level was not statistically different among the SPARC tertiles. Age-adjusted partial correlation revealed significant associations of SPARC with adiponectin, osteopontin, VCAM-1, MMP-2, and PEDF (all p<0.05). Lower SPARC was accompanied by less favorable estimated glomerular filtration rate (eGFR) and carotid–femoral pulse wave velocity (PWV) readings (all p<0.05). Conversely, ankle–brachial index (ABI) reduced with increasing SPARC (p=0.048). The eGFR (B=0.834, p=0.019), PWV (B=−7.925, p=0.009), and ABI (B=−142.160, p=0.010) remained as determinants of SPARC after confounder adjustment. Moreover, individuals in the lowest SPARC tertile had increased odds of aortic stiffness (OR=1.900, 95% CI=1.103−3.274) but reduced odds of peripheral arterial disease (OR=0.400, 95% CI=0.175−0.919). However, SPARC was not independently associated with chronic kidney disease. The anti-angiogenic SPARC may be associated with the pathophysiology of diabetes-related macrovascular complications.