Control of breathing during sleep assessed by proportional assist ventilation

• Published in: Journal of applied physiology (1985) Vol. 84; no. 1; pp. 3 - 12
• Main Authors: Meza, S, Giannouli, E, Younes, M
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01.01.1998; American Physiological Society
• Subjects: Adult; Air Pressure; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Down-Regulation - physiology; Emergency and intensive respiratory care; Female; Humans; Intensive care medicine; Male; Medical sciences; Middle Aged; Polysomnography; Positive-Pressure Respiration - instrumentation; Respiratory Mechanics - physiology; Sleep - physiology; Sleep, REM - physiology; Human; Sleep stage; Assisted ventilation; Respiratory disease; Carbon dioxide; Tidal volume; Artificial ventilation; Rapid eye movement sleep; Pressure; Slow wave sleep; Partial pressure; Respiratory muscle; Respiratory control
• ISSN: 8750-7587; 1522-1601; 1522-1601
• DOI: 10.1152/jappl.1998.84.1.3

Respiratory Investigation Unit, Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3A 1R8 Meza, S., E. Giannouli, and M. Younes. Control of breathing during sleep assessed by proportional assist ventilation. J. Appl. Physiol. 84(1): 3-12, 1998. We used proportional assist ventilation (PAV) to evaluate the sources of respiratory drive during sleep. PAV increases the slope of the relation between tidal volume (V T ) and respiratory muscle pressure output (Pmus). We reasoned that if respiratory drive is dominated by chemical factors, progressive increase of PAV gain should result in only a small increase in V T because Pmus would be downregulated substantially as a result of small decreases in P CO 2 . In the presence of substantial nonchemical sources of drive [believed to be the case in rapid-eye-movement (REM) sleep] PAV should result in a substantial increase in minute ventilation and reduction in P CO 2 as the output related to the chemically insensitive drive source is amplified severalfold. Twelve normal subjects underwent polysomnography while connected to a PAV ventilator. Continuous positive air pressure (5.2 ± 2.0 cmH 2 O) was administered to stabilize the upper airway. PAV was increased in 2-min steps from 0 to 20, 40, 60, 80, and 90% of the subject's elastance and resistance. V T , respiratory rate, minute ventilation, and end-tidal CO 2 pressure were measured at the different levels, and Pmus was calculated. Observations were obtained in stage 2 sleep ( n  = 12), slow-wave sleep ( n  = 11), and REM sleep ( n  = 7). In all cases, Pmus was substantially downregulated with increase in assist so that the increase in V T , although significant ( P  < 0.05), was small (0.08 liter at the highest assist). There was no difference in response between REM and non-REM sleep. We conclude that respiratory drive during sleep is dominated by chemical control and that there is no fundamental difference between REM and non-REM sleep in this regard. REM sleep appears to simply add bidirectional noise to what is basically a chemically controlled respiratory output. rapid-eye-movement sleep; respiratory drive; tidal volume; partial pressure of carbon dioxide; unloading The Journal of Applied Physiology 84(1):3-12 0161-7567/98 $5.00 Copyright © 1998 the American Physiological Society