Protein-protein interactions in polyketide synthase-nonribosomal peptide synthetase hybrid assembly lines
Covering: up to early 2018 Polyketides and nonribosomal peptides are two major families of natural product with a broad range of biological activities. Polyketide synthases (PKSs) assemble small acetic acid-type acyl building blocks into polyketides through C-C bonds, and nonribosomal peptide synthe...
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| Published in | Natural product reports Vol. 35; no. 11; pp. 1185 - 129 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
14.11.2018
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0265-0568 1460-4752 1460-4752 |
| DOI | 10.1039/c8np00022k |
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| Summary: | Covering: up to early 2018
Polyketides and nonribosomal peptides are two major families of natural product with a broad range of biological activities. Polyketide synthases (PKSs) assemble small acetic acid-type acyl building blocks into polyketides through C-C bonds, and nonribosomal peptide synthetases (NRPSs) assemble amino acids into peptides through amide bonds. PKS-NRPS hybrid assembly lines build structurally complex polyketide-amino acid/peptide hybrid molecules that incorporate both acyl and aminoacyl building blocks into their products. Their combined functionalities expand the biological activities of these molecules by mixing their chemical properties. Protein-protein interactions are necessary within PKS-NRPS hybrid assembly lines to achieve accurate linkage between the PKS and NRPS systems. This review summarizes the current understanding of the roles and importance of the protein-protein interactions in various PKS-NRPS hybrid assembly lines.
The protein-protein interactions in polyketide synthase-nonribosomal peptide synthetase hybrids are summarized and discussed. |
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| Bibliography: | Fumitaka Kudo received his B.Sc. in 1994, M.Sc. in 1996, and Ph.D. in 1999 from the Tokyo Institute of Technology under the direction of Katusumi Kakinuma. He was a postdoctoral fellow at Brown University working with David E. Cane from 1999-2001 and at Johns Hopkins University working with Craig A. Townsend from 2001 to 2003. In 2003, he joined the Department of Chemistry at the Tokyo Institute of Technology as an assistant professor and was promoted to associate professor in 2010. His research focuses on bioorganic chemistry in microbial natural product biosynthesis, including aminoglycoside-aminocyclitol antibiotics and polyketide antibiotics. Tadashi Eguchi received his B.Sc. from Yokohama City University in 1980, M.Sc. in 1982 and Ph.D. in 1990 from the Tokyo Institute of Technology. After a stay in the Pharmaceutical Company, he joined Iwaki Meisei University as an assistant professor in 1987. He moved to the Tokyo Institute of Technology as an assistant professor in 1990, and was appointed to associate professor in 1995 and full professor in 2005. His research group is currently working in general research areas with a focus on both the elucidation of biosynthetic pathways of biologically active natural products and the mechanisms of novel enzymatic reactions. Akimasa Miyanaga received his B.Sc. in 2001, M.Sc. in 2003, and Ph.D. in 2006 from The University of Tokyo under the direction of Hirofumi Shoun. He was a postdoctoral fellow at The University of Tokyo working with Sueharu Horinouchi (2006-2009) and at the University of California at San Diego working with Bradley S. Moore (2009-2011). He was appointed to assistant professor at the Tokyo University of Science in 2011 and moved to the Tokyo Institute of Technology as an assistant professor in 2012. His research concerns biochemical and structural studies of natural product biosynthetic enzymes. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 0265-0568 1460-4752 1460-4752 |
| DOI: | 10.1039/c8np00022k |