Two Distinct Broadly Neutralizing Antibody Specificities of Different Clonal Lineages in a Single HIV-1-Infected Donor: Implications for Vaccine Design

• Published in: Journal of Virology Vol. 86; no. 8; pp. 4688 - 4692
• Main Authors: Bonsignori, Mattia, Montefiori, David C., Wu, Xueling, Chen, Xi, Hwang, Kwan-Ki, Tsao, Chun-Yen, Kozink, Daniel M., Parks, Robert J., Tomaras, Georgia D., Crump, John A., Kapiga, Saidi H., Sam, Noel E., Kwong, Peter D., Kepler, Thomas B., Liao, Hua-Xin, Mascola, John R., Haynes, Barton F.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.04.2012
• Subjects: AIDS Vaccines - immunology; Antibodies, Neutralizing - genetics; Antibodies, Neutralizing - immunology; Antibodies, Neutralizing - metabolism; Antibody Specificity - immunology; B-Lymphocytes - immunology; Binding Sites; Biological and medical sciences; CD4 Antigens - chemistry; CD4 Antigens - metabolism; Epitopes - chemistry; Fundamental and applied biological sciences. Psychology; HIV Antibodies - genetics; HIV Antibodies - immunology; HIV Antibodies - metabolism; HIV Envelope Protein gp120 - chemistry; HIV Envelope Protein gp120 - immunology; HIV Infections - immunology; HIV-1 - immunology; Humans; Immunoglobulin Variable Region - chemistry; Immunoglobulin Variable Region - genetics; Microbiology; Miscellaneous; Neutralization Tests; Phylogeny; Vaccines and Antiviral Agents; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Virology; Immunopathology; HIV-1 virus; Retroviridae; AIDS; Vaccine; Immune deficiency; Lentivirus; Neutralizing antibody; Infection; Virus; Specificity; Viral disease; Human immunodeficiency virus
• ISSN: 0022-538X; 1098-5514; 1070-6321; 1098-5514
• DOI: 10.1128/JVI.07163-11

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