Synthesis of Cyclic Imides from Simple Diols

• Published in: Angewandte Chemie (International ed.) Vol. 49; no. 36; pp. 6391 - 6395
• Main Authors: Zhang, Jian, Senthilkumar, Muthaiah, Ghosh, Subhash Chandra, Hong, Soon Hyeok
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley-VCH Verlag 23.08.2010; WILEY-VCH Verlag; WILEY‐VCH Verlag; Wiley
• Subjects: Amines - chemistry; Catalysis; Chemistry; Chemistry, Multidisciplinary; Cyclization; diols; homogeneous catalysis; imides; Imides - chemical synthesis; Imides - chemistry; Methane - analogs & derivatives; Methane - chemistry; N-heterocyclic carbenes; Phthalimides - chemical synthesis; Phthalimides - chemistry; Physical Sciences; Piperidones - chemical synthesis; Piperidones - chemistry; ruthenium; Ruthenium - chemistry; Science & Technology; Succinimides - chemical synthesis; Succinimides - chemistry; CATALYZED CARBONYLATION; diols; RING EXPANSION; LEWIS-ACID; EFFICIENT SYNTHESIS; ALDEHYDES; ALCOHOLS; ruthenium; imides; ARYL BORONIC ACIDS; homogeneous catalysis; AMINES; ESTERS; DIRECT AMIDE SYNTHESIS; N-heterocyclic carbenes
• ISSN: 1433-7851; 1521-3773; 1521-3773
• DOI: 10.1002/anie.201002136

There′s something imide so strong: Cyclic imides were synthesized from simple diols with primary amines in a single step using an in‐situ‐generated ruthenium catalytic system. The atom‐economical and operatively simple syntheses of succinimides, phthalimides, and glutarimides, which are important building blocks in natural products and drugs, was also demonstrated.