Effects of Phenylethanoid Glycosides Extracted from Herba Cistanches on the Learning and Memory of the APP/PSI Transgenic Mice with Alzheimer’s Disease

• Published in: BioMed research international Vol. 2021; no. 1; p. 1291549
• Main Authors: Yang, Jianhua, Ju, Bowei, Hu, Junping
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2021; John Wiley & Sons, Inc
• Subjects: Alzheimer Disease - metabolism; Alzheimer's disease; Analysis; Animal behavior; Animals; Apoptosis; Behavior, Animal - drug effects; Biomedical research; Brain research; Care and treatment; Cistanche - chemistry; Cognition; Cognitive ability; Deoxyribonucleic acid; Diagnosis; Disease; Disease Models, Animal; DNA; Donepezil; Female; Food; Genetic engineering; Glycoproteins; Glycosides; Glycosides - chemistry; Glycosides - isolation & purification; Glycosides - pharmacology; Health aspects; Herbal medicine; Male; Maze Learning - drug effects; Memory; Memory - drug effects; Methods; Mice; Mice, Transgenic; Nesting; Neurodegenerative diseases; Oxidative stress; Pharmacy; Physiological aspects; Plant Extracts - chemistry; R&D; Research & development; Risk factors; Rodents; Transgenic animals; Transgenic mice; China
• ISSN: 2314-6133; 2314-6141; 2314-6141
• DOI: 10.1155/2021/1291549

Background. To investigate the effects of phenylethanoid glycosides (PhGs) extracted from Herba Cistanches on the behavioral and cognition capacity of the APP/PSI transgenic mice with Alzheimer’s disease (AD). Methods. AD mice were randomly divided into the control group, model group, donepezil group, PhG groups, and verbascose group, respectively. Three weeks later, the animals were subject to behavioral and cognition evaluation by the nesting test, Morris water maze test, and step-down test. Results. The cognition capacity in these groups showed a significant increase compared with that in the model group. The step-down test indicated that the errors induced by the memory decrease in the PhG groups and verbascose group showed a significant decrease compared with those in the model group (P<0.05). Conclusions. PhGs attenuated the cognitive dysfunction features of the APP/PSI transgenic gene. Besides, PhGs were the active components for the anti-AD activity of H. Cistanches.