The Studies on the Active Peptide on Smooth Muscle in the Skin of Rana rugosa, Thr6-Bradykinin and Its Analogous Peptide, Ranakinin-R

Thr6-bradykinin and three kinds of its analogous peptides have been isolated from the methanol extract of the fresh skin of Rana rugosa. The longest bradykinin analogue, Thr6-bradykinyl-Ile-Ala-Pro-Glu-Ile-Val, was named ranakinin-R. Serotonin was also identified in the extract. The new peptide whic...

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Published inChemical & pharmaceutical bulletin Vol. 27; no. 2; pp. 486 - 491
Main Authors ISHIKAWA, OSAMU, YASUHARA, TADASHI, ARAKI, KENGO, TACHIBANA, SHINRO, NAKAJIMA, TERUMI
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.01.1979
Japan Science and Technology Agency
Subjects
Animals
Anura
Bradykinin - analogs & derivatives
Bradykinin - isolation & purification
Bradykinin - pharmacology
Female
Guinea Pigs
In Vitro Techniques
Muscle Contraction - drug effects
Muscle, Smooth - drug effects
Ranidae
Rats
sequence analysis
Skin - analysis
Online AccessGet full text
ISSN0009-2363
1347-5223
1347-5223
DOI10.1248/cpb.27.486

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Summary:Thr6-bradykinin and three kinds of its analogous peptides have been isolated from the methanol extract of the fresh skin of Rana rugosa. The longest bradykinin analogue, Thr6-bradykinyl-Ile-Ala-Pro-Glu-Ile-Val, was named ranakinin-R. Serotonin was also identified in the extract. The new peptide which contracts the rat uterus, guinea pig gall bladder and is hypertensive, was isolated and suggested to be the ranatensin or bombesin analogue by these pharmacological properties and by partial sequence analysis of the peptide.
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ISSN:0009-2363
1347-5223
1347-5223
DOI:10.1248/cpb.27.486