Fatal anaphylactic reaction to intravenous gadobutrol, a gadolinium-based MRI contrast agent

We present the rare case of a fatal anaphylactic reaction to gadobutrol, a magnetic resonance imaging contrast agent, in a 42-year-old man. The patient underwent elective magnetic resonance imaging for diagnostic clarification of a suspicious finding in the abdomen. The patient had undergone contras...

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Bibliographic Details
Published inRadiology case reports Vol. 13; no. 1; pp. 299 - 301
Main Authors Franckenberg, Sabine, Berger, Florian, Schaerli, Sarah, Ampanozi, Garyfalia, Thali, Michael
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.02.2018
Elsevier
Subjects
Anaphylactic reaction
Gadobutrol
Gadolinium
MRI
Quality and Safety
Gadolinium
Anaphylactic reaction
Gadobutrol
MRI
Online AccessGet full text
ISSN1930-0433
1930-0433
DOI10.1016/j.radcr.2017.09.012

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Summary:We present the rare case of a fatal anaphylactic reaction to gadobutrol, a magnetic resonance imaging contrast agent, in a 42-year-old man. The patient underwent elective magnetic resonance imaging for diagnostic clarification of a suspicious finding in the abdomen. The patient had undergone contrast-enhanced computed tomography previously without the occurrence of any adverse effects. Adverse drug reactions in gadobutrol have a very low prevalence of 0.32%-3.5%, with serious adverse drug reactions in <0.1%. There are only a few cases of fatal anaphylactoid reactions to gadolinium-based contrast agents in general. However, if an anaphylactoid reaction occurs, it can present itself with a fulminant course within minutes.
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ISSN:1930-0433
1930-0433
DOI:10.1016/j.radcr.2017.09.012