Effect of Tapentadol on Dogs’ Minimum Alveolar Concentration (MAC) of Isoflurane

• Published in: Animals (Basel) Vol. 15; no. 10; p. 1381
• Main Authors: Ibancovichi-Camarillo, José Antonio, Chávez-Monteagudo, Julio Raúl, De Paz-Campos, Marco Antonio, Gutiérrez-Olvera, Lilia, Sumano-López, Héctor Salvador
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.05.2025; MDPI
• Subjects: Analgesics; Anesthesia; Blood pressure; Catheters; Dexmedetomidine; Dogs; Drug dosages; Experiments; Isoflurane; Medical research; Narcotics; norepinephrine; Statistical analysis; tapentadol; μ-opioid receptor; Mexico; United States > US; China; Shenzhen China; norepinephrine; dogs; tapentadol; isoflurane; μ-opioid receptor
• ISSN: 2076-2615; 2076-2615
• DOI: 10.3390/ani15101381

To evaluate the effect of oral administration of 10 mg kg−1 tapentadol on dogs’ minimum alveolar concentration of isoflurane. The MAC of isoflurane was determined in seven dogs without previous medication (Group MACISO) and 2 h 30 min after the administration of 10 mg kg−1 of tapentadol orally (Group MACISO+TAP). The MAC was determined by pinching the fourth finger of the pelvic limb. Data normality was analyzed using the Shapiro–Wilk test. Student’s t-test was used to evaluate the effect of tapentadol on isoflurane MAC and cardiovascular variables. The minimum alveolar concentration obtained in the Group MACISO was 1.52 ± 0.02%, and in the Group MACISO+TAP, it was 1.47 ± 0.03%, observing a significant statistical difference between groups (p = 0.01). The reduction in the MAC caused by administering 10 mg kg−1 of Tapentadol was 3.29%. No statistically significant differences were observed when the heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were compared between groups. The oral administration of 10 mg kg−1 tapentadol reduces dogs’ minimum alveolar concentration of isoflurane without alterations in the heart rate and systemic blood pressure.