Brain stem hemorrhage due to cerebral amyloid angiopathy: The autopsy of a patient with Alzheimer’s disease at a young age

• Published in: Legal medicine (Tokyo, Japan) Vol. 16; no. 2; pp. 98 - 101
• Main Authors: Ohtani, Seiji, Shimizu, Keiko, Asari, Masaru, Maseda, Chikatoshi, Oka, Kumiko, Yamada, Hiromi, Hoshina, Chisato, Doi, Hiroki, Yajima, Daisuke, Shiono, Hiroshi, Ogawa, Katsuhiro
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.03.2014
• Subjects: Alzheimer Disease - pathology; Amyloid β; Cerebellum - pathology; Cerebral amyloid angiopathy; Cerebral Amyloid Angiopathy - pathology; Humans; Hypertension - diagnosis; Internal Medicine; Intracerebral hemorrhage; Intracranial Hemorrhages - etiology; Intracranial Hemorrhages - pathology; Male; Middle Aged; Necrosis; Neurofibrillary tangles; Neurofibrillary Tangles - pathology; Plaque, Amyloid - pathology; Pons - pathology; Senile plaques; Cerebral amyloid angiopathy; Neurofibrillary tangles; Senile plaques; Amyloid β; Intracerebral hemorrhage
• ISSN: 1344-6223; 1873-4162; 1873-4162
• DOI: 10.1016/j.legalmed.2014.01.003

We report findings from an autopsy of a male in his 40s who died of a brain stem hemorrhage associated with cerebral amyloid angiopathy (CAA), senile plaques (SPs) and neurofibrillary tangles (NFTs), which are histopathological changes associated with Alzheimer’s disease (AD). Our immunohistochemical study demonstrated amyloid β (Aβ) deposition in the small cerebral arteries and SPs. Although hypertension (178/132mmHg) was detected, the subject was not treated accordingly. CAA coupled with hypertension might have caused the intracerebral hemorrhage (ICH).