Partial pulpotomy on caries-free teeth using enamel matrix derivative or calcium hydroxide: a randomized controlled trial
Aim To compare the effect of enamel matrix derivative (EMD) and calcium hydroxide [Ca(OH)2] on exposed human pulp. Methodology Fifteen pairs of human contralateral premolars were intentionally and partially pulpotomized. The exposed pulps were randomly capped with either EMDgel (Emdogain®) or a mi...
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Published in | International endodontic journal Vol. 42; no. 7; pp. 584 - 592 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.07.2009
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Subjects | |
Online Access | Get full text |
ISSN | 0143-2885 1365-2591 1365-2591 |
DOI | 10.1111/j.1365-2591.2009.01552.x |
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Summary: | Aim To compare the effect of enamel matrix derivative (EMD) and calcium hydroxide [Ca(OH)2] on exposed human pulp.
Methodology Fifteen pairs of human contralateral premolars were intentionally and partially pulpotomized. The exposed pulps were randomly capped with either EMDgel (Emdogain®) or a mix of Ca(OH)2 and sterile water. The subjects recorded pain or discomfort during the first 10 days and were also interviewed and examined by a blinded examiner at 1 day, 2 weeks, 3 and 6 months post‐operation. Periapical radiographs were taken prior to the operation, and 3 and 6 months post‐operation. After 6 months, the teeth were extracted and processed for histological evaluation. The data were described and analysed using McNemar test and Kaplan–Meier survival analysis.
Results The EMDgel‐treated teeth had significantly less tooth hypersensitivity than the Ca(OH)2‐treated teeth during the first 2 weeks (P = 0.031) but were not significantly different after 2 weeks (P = 0.125). No detectable periapical radiographic changes were observed in any teeth and radiographic evidence of dentine bridge formation from both groups were not significantly different during the follow‐up periods (P > 0.05). Histological evaluation demonstrated that the Ca(OH)2‐treated teeth had less inflammation and more dentine bridge formation than those in the EMDgel‐treated teeth.
Conclusions After 6 months, healthy pulps capped with Ca(OH)2 had more favourable results than counterparts capped with EMDgel. However, similar clinical and radiographic results were seen in both groups. |
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Bibliography: | istex:4613B24F97016817656D0D32DAB55B50A8EA5143 ArticleID:IEJ1552 ark:/67375/WNG-9NN92QV8-7 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3 |
ISSN: | 0143-2885 1365-2591 1365-2591 |
DOI: | 10.1111/j.1365-2591.2009.01552.x |