Elucidating the molecular circuitry of autoimmunity

Novel single-cell profiling technologies have delineated the cellular and molecular landscapes that dominate the joints in rheumatoid arthritis and the skin and kidneys in systemic lupus erythematosus, shedding light on potential pathogenic mechanisms.

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Published inNature immunology Vol. 20; no. 7; pp. 777 - 778
Main Authors Varadarajan, Navin, Mohan, Chandra
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.07.2019
Nature Publishing Group
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ISSN1529-2908
1529-2916
1529-2916
DOI10.1038/s41590-019-0436-8

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Abstract Novel single-cell profiling technologies have delineated the cellular and molecular landscapes that dominate the joints in rheumatoid arthritis and the skin and kidneys in systemic lupus erythematosus, shedding light on potential pathogenic mechanisms.
AbstractList Novel single-cell profiling technologies have delineated the cellular and molecular landscapes that dominate the joints in rheumatoid arthritis and the skin and kidneys in systemic lupus erythematosus, shedding light on potential pathogenic mechanisms.
Audience Academic
Author Mohan, Chandra
Varadarajan, Navin
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  surname: Mohan
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Cites_doi 10.1038/s41590-019-0398-x
10.1038/s41590-019-0386-1
10.1016/j.cell.2016.04.019
10.1038/s41590-019-0378-1
10.1038/s41423-019-0214-4
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Snippet Novel single-cell profiling technologies have delineated the cellular and molecular landscapes that dominate the joints in rheumatoid arthritis and the skin...
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SubjectTerms 631/1647/2017
631/250/249/1313/1613/1614
631/250/249/1313/498
631/250/256/2515
631/250/38
Animals
Autoimmune diseases
Autoimmune Diseases - diagnosis
Autoimmune Diseases - etiology
Autoimmune Diseases - metabolism
Autoimmunity
Autoimmunity - genetics
B cells
Biomarkers
Biomedical and Life Sciences
Biomedicine
Correlation analysis
Cytokines
Disease
Flow cytometry
Gene Expression Profiling
Humans
Hypotheses
Immunology
Infectious Diseases
Inflammation
Joint diseases
Kidneys
Ligands
Lupus
Lymphocytes
News & Views
news-and-views
Protein expression
Proteins
Rheumatoid arthritis
Rheumatoid factor
Single-Cell Analysis - methods
Skin
Systemic lupus erythematosus
Transcriptome
Urine
Title Elucidating the molecular circuitry of autoimmunity
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