Integrated analysis of FANCE expression and its regulatory role in the immune microenvironment of oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) presents a significant health challenge owing to its complex origin and limited treatment success. The precise function of Fanconi anemia complementation group E (FANCE), a key gene involved in DNA repair in OSCC, remains unclear. The present study performed bioin...
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| Published in | Oncology letters Vol. 29; no. 3; p. 160 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Greece
D.A. Spandidos
01.03.2025
Spandidos Publications Spandidos Publications UK Ltd |
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| Online Access | Get full text |
| ISSN | 1792-1074 1792-1082 1792-1082 |
| DOI | 10.3892/ol.2025.14906 |
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| Abstract | Oral squamous cell carcinoma (OSCC) presents a significant health challenge owing to its complex origin and limited treatment success. The precise function of Fanconi anemia complementation group E (FANCE), a key gene involved in DNA repair in OSCC, remains unclear. The present study performed bioinformatics analysis of The Cancer Genome Atlas dataset and cellular experiments to demonstrate that FANCE is significantly upregulated in OSCC. Enhanced FANCE expression was associated with poor survival outcome in patients with OSCC. Knockdown of FANCE inhibited OSCC cell proliferation and migration. Moreover, a negative correlation was observed between FANCE expression and immune cell markers. Collectively, these findings suggest that FANCE is a potential oncogene in OSCC and a prognostic biomarker that may play a role in modulating the OSCC microenvironment. |
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| AbstractList | Oral squamous cell carcinoma (OSCC) presents a significant health challenge owing to its complex origin and limited treatment success. The precise function of Fanconi anemia complementation group E (FANCE), a key gene involved in DNA repair in OSCC, remains unclear. The present study performed bioinformatics analysis of The Cancer Genome Atlas dataset and cellular experiments to demonstrate that FANCE is significantly upregulated in OSCC. Enhanced FANCE expression was associated with poor survival outcome in patients with OSCC. Knockdown of FANCE inhibited OSCC cell proliferation and migration. Moreover, a negative correlation was observed between FANCE expression and immune cell markers. Collectively, these findings suggest that FANCE is a potential oncogene in OSCC and a prognostic biomarker that may play a role in modulating the OSCC microenvironment. Oral squamous cell carcinoma (OSCC) presents a significant health challenge owing to its complex origin and limited treatment success. The precise function of Fanconi anemia complementation group E (FANCE), a key gene involved in DNA repair in OSCC, remains unclear. The present study performed bioinformatics analysis of The Cancer Genome Atlas dataset and cellular experiments to demonstrate that FANCE is significantly upregulated in OSCC. Enhanced FANCE expression was associated with poor survival outcome in patients with OSCC. Knockdown of FANCE inhibited OSCC cell proliferation and migration. Moreover, a negative correlation was observed between FANCE expression and immune cell markers. Collectively, these findings suggest that FANCE is a potential oncogene in OSCC and a prognostic biomarker that may play a role in modulating the OSCC microenvironment. Key words: oral squamous cell carcinoma, Fanconi anemia complementation group E, biomarker, prognosis, tumor microenvironment |
| ArticleNumber | 160 |
| Audience | Academic |
| Author | Zhou, Jian Chen, Yuling Li, Xiaolian Yang, Hongyu Lin, Bo Lin, Yuntao Shen, Yuehong |
| AuthorAffiliation | 2 Department of Oral and Maxillofacial Surgery, Guangdong Provincial High-level Clinical Key Specialty, Shenzhen, Guangdong 518036, P.R. China 3 Department of Oral and Maxillofacial Surgery, Guangdong Province Engineering Research Center of Oral Disease Diagnosis and Treatment, Shenzhen, Guangdong 518036, P.R. China 4 Institute of Stomatology, Shenzhen Clinical Research Center for Oral Diseases, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong 518036, P.R. China 1 Department of Oral and Maxillofacial Surgery, Stomatological Center, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China |
| AuthorAffiliation_xml | – name: 4 Institute of Stomatology, Shenzhen Clinical Research Center for Oral Diseases, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong 518036, P.R. China – name: 1 Department of Oral and Maxillofacial Surgery, Stomatological Center, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China – name: 2 Department of Oral and Maxillofacial Surgery, Guangdong Provincial High-level Clinical Key Specialty, Shenzhen, Guangdong 518036, P.R. China – name: 3 Department of Oral and Maxillofacial Surgery, Guangdong Province Engineering Research Center of Oral Disease Diagnosis and Treatment, Shenzhen, Guangdong 518036, P.R. China |
| Author_xml | – sequence: 1 givenname: Bo surname: Lin fullname: Lin, Bo organization: 1Department of Oral and Maxillofacial Surgery, Stomatological Center, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China – sequence: 2 givenname: Yuling surname: Chen fullname: Chen, Yuling organization: 1Department of Oral and Maxillofacial Surgery, Stomatological Center, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China – sequence: 3 givenname: Xiaolian surname: Li fullname: Li, Xiaolian organization: 1Department of Oral and Maxillofacial Surgery, Stomatological Center, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China – sequence: 4 givenname: Yuntao surname: Lin fullname: Lin, Yuntao organization: 1Department of Oral and Maxillofacial Surgery, Stomatological Center, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China – sequence: 5 givenname: Jian surname: Zhou fullname: Zhou, Jian organization: 1Department of Oral and Maxillofacial Surgery, Stomatological Center, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China – sequence: 6 givenname: Hongyu surname: Yang fullname: Yang, Hongyu organization: 1Department of Oral and Maxillofacial Surgery, Stomatological Center, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China – sequence: 7 givenname: Yuehong surname: Shen fullname: Shen, Yuehong organization: 1Department of Oral and Maxillofacial Surgery, Stomatological Center, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39911149$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/nprot.2008.73 10.1016/j.imbio.2021.152072 10.1038/nmeth.3337 10.3389/fgene.2022.1024989 10.1074/jbc.M507758200 10.1016/j.ebiom.2020.103081 10.1016/S0140-6736(15)60851-0 10.18632/aging.202499 10.1159/000520582 10.1007/978-1-4939-7493-1_12 10.1186/s13059-017-1349-1 10.3389/fonc.2019.01512 10.3390/cancers12040829 10.1038/nrclinonc.2016.217 10.7150/jca.86348 10.1111/ijlh.13986 10.2174/156652309787354667 10.1142/S0129065712500189 10.1074/jbc.M113.533976 10.1038/nm852 10.1155/2012/603253 10.1158/1078-0432.CCR-21-3581 10.1371/journal.pone.0144285 10.1111/j.1365-2567.2011.03541.x 10.1159/000525375 10.3322/caac.21293 10.1002/humu.24286 10.7150/thno.65411 10.1016/j.canlet.2005.12.028 10.1371/journal.pone.0159800 |
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| GrantInformation | The present research was supported by The Basic Research Program of Shenzhen Innovation Council (grant no. JCYJ20210324110014037), Shenzhen Clinical Medical Research Center for Oral Diseases (grant no. 20210617170745001-SCRC202201001) and Shenzhen High-level Hospital Construction Fund, Peking University Shenzhen Hospital Scientific Research Fund (grant no. KYQD2023253). |
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| Keywords | oral squamous cell carcinoma tumor microenvironment biomarker prognosis Fanconi anemia complementation group E |
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| SubjectTerms | Algorithms Anemia biomarker Biotechnology Cancer Cell growth Clustering Development and progression DNA damage DNA methylation DNA repair Fanconi anemia complementation group E Gene expression Genetic aspects Genetic engineering Health aspects Mouth cancer Oral cancer oral squamous cell carcinoma Prognosis Squamous cell carcinoma Statistical significance tumor microenvironment Wound healing |
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