Integrated analysis of FANCE expression and its regulatory role in the immune microenvironment of oral squamous cell carcinoma

• Published in: Oncology letters Vol. 29; no. 3; p. 160
• Main Authors: Lin, Bo, Chen, Yuling, Li, Xiaolian, Lin, Yuntao, Zhou, Jian, Yang, Hongyu, Shen, Yuehong
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.03.2025; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Algorithms; Anemia; biomarker; Biotechnology; Cancer; Cell growth; Clustering; Development and progression; DNA damage; DNA methylation; DNA repair; Fanconi anemia complementation group E; Gene expression; Genetic aspects; Genetic engineering; Health aspects; Mouth cancer; Oral cancer; oral squamous cell carcinoma; Prognosis; Squamous cell carcinoma; Statistical significance; tumor microenvironment; Wound healing; China; oral squamous cell carcinoma; tumor microenvironment; biomarker; prognosis; Fanconi anemia complementation group E
• ISSN: 1792-1074; 1792-1082; 1792-1082
• DOI: 10.3892/ol.2025.14906

Oral squamous cell carcinoma (OSCC) presents a significant health challenge owing to its complex origin and limited treatment success. The precise function of Fanconi anemia complementation group E (FANCE), a key gene involved in DNA repair in OSCC, remains unclear. The present study performed bioinformatics analysis of The Cancer Genome Atlas dataset and cellular experiments to demonstrate that FANCE is significantly upregulated in OSCC. Enhanced FANCE expression was associated with poor survival outcome in patients with OSCC. Knockdown of FANCE inhibited OSCC cell proliferation and migration. Moreover, a negative correlation was observed between FANCE expression and immune cell markers. Collectively, these findings suggest that FANCE is a potential oncogene in OSCC and a prognostic biomarker that may play a role in modulating the OSCC microenvironment.