Activating and inhibitory receptors expressed on innate lymphoid cells

• Published in: Seminars in immunopathology Vol. 40; no. 4; pp. 331 - 341
• Main Authors: Guia, Sophie, Fenis, Aurore, Vivier, Eric, Narni-Mancinelli, Emilie
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2018; Springer Nature B.V; Springer Verlag
• Subjects: Animals; Antigens; Biomedical and Life Sciences; Biomedicine; Cell interactions; Cytokines; Cytomegalovirus; Cytotoxicity; Gene Expression Regulation; Growth factors; Heparan sulfate; Homeostasis; Host-Pathogen Interactions - genetics; Host-Pathogen Interactions - immunology; Humans; Immunity, Innate; Immunology; Influenza; Internal Medicine; Killer Cells, Natural - immunology; Killer Cells, Natural - metabolism; Life Sciences; Ligands; Lymphocyte Activation - genetics; Lymphocyte Activation - immunology; Lymphocyte Subsets - immunology; Lymphocyte Subsets - metabolism; Lymphoid cells; Lymphoid tissue; Measles; Mucosa; Natural killer cells; Protein Binding; Proteins; Receptors, Immunologic - genetics; Receptors, Immunologic - metabolism; Review; Signal Transduction; Tumor necrosis factor-TNF; Viruses; West Nile virus; ILC; NK cells; NCR; Checkpoints
• ISSN: 1863-2297; 1863-2300; 1863-2300
• DOI: 10.1007/s00281-018-0685-x

Innate lymphoid cells (ILCs) are innate immune cells located in lymphoid and non-lymphoid tissues. They are particularly abundant at mucosal and barrier surfaces. Three major ILC subsets are present in humans and mice: group 1 ILCs (comprising natural killer (NK) cells and ILC1s), ILC2s, and ILC3s. ILCs are involved in the maintenance of homeostasis and the regulation of immunity. This review focuses on the extensive array of activating and inhibitory receptors expressed by ILCs for communication with other cell types and their environment in health and disease.