Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review
Backgrounds. The objective of the present research was to systematically revise the international literature about the genetic biomarkers related to oral cancer (OC) evaluating the recent findings in clinical studies. Methods. A comprehensive review of the current literature was conducted according...
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| Published in | Disease markers Vol. 2019; no. 2019; pp. 1 - 11 |
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| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cairo, Egypt
Hindawi Publishing Corporation
01.01.2019
Hindawi John Wiley & Sons, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0278-0240 1875-8630 1875-8630 |
| DOI | 10.1155/2019/8040361 |
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| Abstract | Backgrounds. The objective of the present research was to systematically revise the international literature about the genetic biomarkers related to oral cancer (OC) evaluating the recent findings in clinical studies. Methods. A comprehensive review of the current literature was conducted according to the PRISMA guidelines by accessing the NCBI PubMed database. The authors conducted the search of articles in the English language published from 2008 to 2018. The present systematic review included only papers with significant results about correlation between wound healing, genetic alteration, and OC. Prognostic capacity of genetic markers was not evaluated in vivo. Results. The first analysis with filters recorded about 1884 published papers. Beyond reading and consideration of suitability, only 20 and then 8 papers, with case report exclusion, were recorded for the revision. Conclusion. All the researches recorded the proteomic and genetic alterations in OC human biopsy cells. The gene modification level in the different studies, compared with samples of healthy tissues, has always been statistically significant, but it is not possible to associate publications with each other because each job is based on the measurement of different biomarkers and gene targets. Further investigations should be required in order to state scientific evidence about a clear advantage of using these biomarkers for diagnostic purpose. |
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| AbstractList | Backgrounds. The objective of the present research was to systematically revise the international literature about the genetic biomarkers related to oral cancer (OC) evaluating the recent findings in clinical studies. Methods. A comprehensive review of the current literature was conducted according to the PRISMA guidelines by accessing the NCBI PubMed database. The authors conducted the search of articles in the English language published from 2008 to 2018. The present systematic review included only papers with significant results about correlation between wound healing, genetic alteration, and OC. Prognostic capacity of genetic markers was not evaluated in vivo. Results. The first analysis with filters recorded about 1884 published papers. Beyond reading and consideration of suitability, only 20 and then 8 papers, with case report exclusion, were recorded for the revision. Conclusion. All the researches recorded the proteomic and genetic alterations in OC human biopsy cells. The gene modification level in the different studies, compared with samples of healthy tissues, has always been statistically significant, but it is not possible to associate publications with each other because each job is based on the measurement of different biomarkers and gene targets. Further investigations should be required in order to state scientific evidence about a clear advantage of using these biomarkers for diagnostic purpose. The objective of the present research was to systematically revise the international literature about the genetic biomarkers related to oral cancer (OC) evaluating the recent findings in clinical studies.BACKGROUNDSThe objective of the present research was to systematically revise the international literature about the genetic biomarkers related to oral cancer (OC) evaluating the recent findings in clinical studies.A comprehensive review of the current literature was conducted according to the PRISMA guidelines by accessing the NCBI PubMed database. The authors conducted the search of articles in the English language published from 2008 to 2018. The present systematic review included only papers with significant results about correlation between wound healing, genetic alteration, and OC. Prognostic capacity of genetic markers was not evaluated in vivo.METHODSA comprehensive review of the current literature was conducted according to the PRISMA guidelines by accessing the NCBI PubMed database. The authors conducted the search of articles in the English language published from 2008 to 2018. The present systematic review included only papers with significant results about correlation between wound healing, genetic alteration, and OC. Prognostic capacity of genetic markers was not evaluated in vivo.The first analysis with filters recorded about 1884 published papers. Beyond reading and consideration of suitability, only 20 and then 8 papers, with case report exclusion, were recorded for the revision.RESULTSThe first analysis with filters recorded about 1884 published papers. Beyond reading and consideration of suitability, only 20 and then 8 papers, with case report exclusion, were recorded for the revision.All the researches recorded the proteomic and genetic alterations in OC human biopsy cells. The gene modification level in the different studies, compared with samples of healthy tissues, has always been statistically significant, but it is not possible to associate publications with each other because each job is based on the measurement of different biomarkers and gene targets. Further investigations should be required in order to state scientific evidence about a clear advantage of using these biomarkers for diagnostic purpose.CONCLUSIONAll the researches recorded the proteomic and genetic alterations in OC human biopsy cells. The gene modification level in the different studies, compared with samples of healthy tissues, has always been statistically significant, but it is not possible to associate publications with each other because each job is based on the measurement of different biomarkers and gene targets. Further investigations should be required in order to state scientific evidence about a clear advantage of using these biomarkers for diagnostic purpose. The objective of the present research was to systematically revise the international literature about the genetic biomarkers related to oral cancer (OC) evaluating the recent findings in clinical studies. A comprehensive review of the current literature was conducted according to the PRISMA guidelines by accessing the NCBI PubMed database. The authors conducted the search of articles in the English language published from 2008 to 2018. The present systematic review included only papers with significant results about correlation between wound healing, genetic alteration, and OC. Prognostic capacity of genetic markers was not evaluated in vivo. The first analysis with filters recorded about 1884 published papers. Beyond reading and consideration of suitability, only 20 and then 8 papers, with case report exclusion, were recorded for the revision. All the researches recorded the proteomic and genetic alterations in OC human biopsy cells. The gene modification level in the different studies, compared with samples of healthy tissues, has always been statistically significant, but it is not possible to associate publications with each other because each job is based on the measurement of different biomarkers and gene targets. Further investigations should be required in order to state scientific evidence about a clear advantage of using these biomarkers for diagnostic purpose. Backgrounds . The objective of the present research was to systematically revise the international literature about the genetic biomarkers related to oral cancer (OC) evaluating the recent findings in clinical studies. Methods . A comprehensive review of the current literature was conducted according to the PRISMA guidelines by accessing the NCBI PubMed database. The authors conducted the search of articles in the English language published from 2008 to 2018. The present systematic review included only papers with significant results about correlation between wound healing, genetic alteration, and OC. Prognostic capacity of genetic markers was not evaluated in vivo. Results . The first analysis with filters recorded about 1884 published papers. Beyond reading and consideration of suitability, only 20 and then 8 papers, with case report exclusion, were recorded for the revision. Conclusion . All the researches recorded the proteomic and genetic alterations in OC human biopsy cells. The gene modification level in the different studies, compared with samples of healthy tissues, has always been statistically significant, but it is not possible to associate publications with each other because each job is based on the measurement of different biomarkers and gene targets. Further investigations should be required in order to state scientific evidence about a clear advantage of using these biomarkers for diagnostic purpose. |
| Audience | Academic |
| Author | De Stefano, Rosa Crimi, Salvatore Fiorillo, Luca D’Amico, Cesare Herford, Alan Scott Cicciù, Marco Santoro, Rossella Bianchi, Alberto Umberto, Romeo Cervino, G. Troiano, Giuseppe Laino, Gregorio Laino, Luigi |
| AuthorAffiliation | 3 Department of Oral and Maxillofacial Sciences, Paediatric Dentistry Unit, “Sapienza” University of Rome, Roma 00161, Italy 2 Department of Maxillofacial Surgery, Loma Linda University, Loma Linda, CA 92354, USA 6 Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania “Luigi Vanvitelli”, 80121 Naples 80121, Italy 5 Departments of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, Italy 4 Department of Maxillofacial Surgery and Surgical Disciplines, University of Catania, Catania 98100, Italy 1 Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, Messina 98100, Italy |
| AuthorAffiliation_xml | – name: 4 Department of Maxillofacial Surgery and Surgical Disciplines, University of Catania, Catania 98100, Italy – name: 1 Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, Messina University, Messina 98100, Italy – name: 6 Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania “Luigi Vanvitelli”, 80121 Naples 80121, Italy – name: 5 Departments of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, Italy – name: 3 Department of Oral and Maxillofacial Sciences, Paediatric Dentistry Unit, “Sapienza” University of Rome, Roma 00161, Italy – name: 2 Department of Maxillofacial Surgery, Loma Linda University, Loma Linda, CA 92354, USA |
| Author_xml | – sequence: 1 fullname: Santoro, Rossella – sequence: 2 fullname: Laino, Luigi – sequence: 3 fullname: Laino, Gregorio – sequence: 4 fullname: Cicciù, Marco – sequence: 5 fullname: De Stefano, Rosa – sequence: 6 fullname: D’Amico, Cesare – sequence: 7 fullname: Crimi, Salvatore – sequence: 8 fullname: Bianchi, Alberto – sequence: 9 fullname: Umberto, Romeo – sequence: 10 fullname: Herford, Alan Scott – sequence: 11 fullname: Fiorillo, Luca – sequence: 12 fullname: Cervino, G. – sequence: 13 fullname: Troiano, Giuseppe |
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| ContentType | Journal Article |
| Copyright | Copyright © 2019 Gabriele Cervino et al. COPYRIGHT 2019 John Wiley & Sons, Inc. Copyright © 2019 Gabriele Cervino et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0 Copyright © 2019 Gabriele Cervino et al. 2019 |
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| SubjectTerms | Angiogenesis Bioindicators Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biopsy Cancer Carcinoma - genetics Carcinoma - metabolism Carcinoma - pathology Clinical trials Clinical Trials as Topic Diagnostic systems Disease English language Evaluation Studies as Topic Genes Genetic aspects Genetic markers Genetic modification Genetically modified organisms Histology Humans Keywords Literature reviews Medical prognosis Medical research Medical Subject Headings-MeSH Methods Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Oncology, Experimental Oral cancer Oral carcinoma Pathology Proteins Review Reviews Statistical analysis Statistical methods Wound healing |
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| Title | Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review |
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