MicroRNA-219-5p Promotes Tumor Growth and Metastasis of Hepatocellular Carcinoma by Regulating Cadherin 1

MicroRNAs play significant roles in the development of cancer and may serve as promising therapeutic targets. In our previous work, miR-219-5p was identified as one of the important metastasis-related microRNAs in HCC. Here we demonstrated that miR-219-5p expression was elevated in HCC tissues and w...

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Published inBioMed research international Vol. 2018; no. 2018; pp. 1 - 10
Main Authors Qin, Lun-Xiu, Jia, Hu-Liang, Zhu, Ying, Gao, Xiao-Mei, Wei, Jin-Wang, Sheng, Yuan-Yuan, Yang, Jing, Dong, Qiong Z.
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2018
Hindawi
John Wiley & Sons, Inc
Subjects
Analysis
Animal models
Apoptosis
Biology
Biomarkers, Tumor - biosynthesis
Cadherins
Cadherins - biosynthesis
Cancer
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Cell adhesion & migration
Cell cycle
Cell growth
Cell proliferation
Development and progression
E-cadherin
Female
Flow cytometry
Gene Expression Regulation, Neoplastic
Growth
Health aspects
Hep G2 Cells
Hepatocellular carcinoma
Hepatology
Humans
Laboratory animals
Liver cancer
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Male
Manufacturers
Medical prognosis
Medical research
Metastases
Metastasis
MicroRNA
MicroRNAs
MicroRNAs - biosynthesis
miRNA
Multivariate analysis
Neoplasm Metastasis
Neoplasm Proteins - biosynthesis
Patients
Prognosis
Ribonucleic acid
RNA
RNA, Neoplasm - biosynthesis
Therapeutic applications
Tumors
China
United States > US
Online AccessGet full text
ISSN2314-6133
2314-6141
2314-6141
DOI10.1155/2018/4793971

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Abstract MicroRNAs play significant roles in the development of cancer and may serve as promising therapeutic targets. In our previous work, miR-219-5p was identified as one of the important metastasis-related microRNAs in HCC. Here we demonstrated that miR-219-5p expression was elevated in HCC tissues and was associated with vascular invasion and dismal prognosis. In multivariate analysis, miR-219-5p was identified as an independent prognostic indicator for HCC patients. Functional mechanism analyses showed that miR-219-5p promoted HCC cell proliferation and invasion in in vitro, as well as in vivo, tumor growth and metastasis in nude mice models bearing human HCC tumors. In addition, cadherin 1 (CDH1) was revealed to be a downstream target of miR-219-5p in HCC cells. In conclusion, miR-219-5p promotes tumor growth and metastasis of HCC by regulating CDH1 and can serve as a prognostic marker for HCC patients.
AbstractList MicroRNAs play significant roles in the development of cancer and may serve as promising therapeutic targets. In our previous work, miR-219-5p was identified as one of the important metastasis-related microRNAs in HCC. Here we demonstrated that miR-219-5p expression was elevated in HCC tissues and was associated with vascular invasion and dismal prognosis. In multivariate analysis, miR-219-5p was identified as an independent prognostic indicator for HCC patients. Functional mechanism analyses showed that miR-219-5p promoted HCC cell proliferation and invasion in in vitro, as well as in vivo, tumor growth and metastasis in nude mice models bearing human HCC tumors. In addition, cadherin 1 (CDH1) was revealed to be a downstream target of miR-219-5p in HCC cells. In conclusion, miR-219-5p promotes tumor growth and metastasis of HCC by regulating CDH1 and can serve as a prognostic marker for HCC patients.
MicroRNAs play significant roles in the development of cancer and may serve as promising therapeutic targets. In our previous work, miR-219-5p was identified as one of the important metastasis-related microRNAs in HCC. Here we demonstrated that miR-219-5p expression was elevated in HCC tissues and was associated with vascular invasion and dismal prognosis. In multivariate analysis, miR-219-5p was identified as an independent prognostic indicator for HCC patients. Functional mechanism analyses showed that miR-219-5p promoted HCC cell proliferation and invasion in in vitro , as well as in vivo , tumor growth and metastasis in nude mice models bearing human HCC tumors. In addition, cadherin 1 (CDH1) was revealed to be a downstream target of miR-219-5p in HCC cells. In conclusion, miR-219-5p promotes tumor growth and metastasis of HCC by regulating CDH1 and can serve as a prognostic marker for HCC patients.
MicroRNAs play significant roles in the development of cancer and may serve as promising therapeutic targets. In our previous work, miR-219-5p was identified as one of the important metastasis-related microRNAs in HCC. Here we demonstrated that miR-219-5p expression was elevated in HCC tissues and was associated with vascular invasion and dismal prognosis. In multivariate analysis, miR-219-5p was identified as an independent prognostic indicator for HCC patients. Functional mechanism analyses showed that miR-219-5p promoted HCC cell proliferation and invasion in in vitro, as well as in vivo, tumor growth and metastasis in nude mice models bearing human HCC tumors. In addition, cadherin 1 (CDH1) was revealed to be a downstream target of miR-219-5p in HCC cells. In conclusion, miR-219-5p promotes tumor growth and metastasis of HCC by regulating CDH1 and can serve as a prognostic marker for HCC patients.MicroRNAs play significant roles in the development of cancer and may serve as promising therapeutic targets. In our previous work, miR-219-5p was identified as one of the important metastasis-related microRNAs in HCC. Here we demonstrated that miR-219-5p expression was elevated in HCC tissues and was associated with vascular invasion and dismal prognosis. In multivariate analysis, miR-219-5p was identified as an independent prognostic indicator for HCC patients. Functional mechanism analyses showed that miR-219-5p promoted HCC cell proliferation and invasion in in vitro, as well as in vivo, tumor growth and metastasis in nude mice models bearing human HCC tumors. In addition, cadherin 1 (CDH1) was revealed to be a downstream target of miR-219-5p in HCC cells. In conclusion, miR-219-5p promotes tumor growth and metastasis of HCC by regulating CDH1 and can serve as a prognostic marker for HCC patients.
MicroRNAs play significant roles in the development of cancer and may serve as promising therapeutic targets. In our previous work, miR-219-5p was identified as one of the important metastasis-related microRNAs in HCC. Here we demonstrated that miR-219-5p expression was elevated in HCC tissues and was associated with vascular invasion and dismal prognosis. In multivariate analysis, miR-219-5p was identified as an independent prognostic indicator for HCC patients. Functional mechanism analyses showed that miR-219-5p promoted HCC cell proliferation and invasion in , as well as , tumor growth and metastasis in nude mice models bearing human HCC tumors. In addition, cadherin 1 (CDH1) was revealed to be a downstream target of miR-219-5p in HCC cells. In conclusion, miR-219-5p promotes tumor growth and metastasis of HCC by regulating CDH1 and can serve as a prognostic marker for HCC patients.
Audience Academic
Author Zhu, Ying
Wei, Jin-Wang
Gao, Xiao-Mei
Dong, Qiong Z.
Yang, Jing
Jia, Hu-Liang
Sheng, Yuan-Yuan
Qin, Lun-Xiu
AuthorAffiliation 2 Institutes of Biomedical Sciences, Fudan University, 131 Dong An Road, Shanghai 200032, China
1 Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai 200040, China
AuthorAffiliation_xml – name: 1 Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai 200040, China
– name: 2 Institutes of Biomedical Sciences, Fudan University, 131 Dong An Road, Shanghai 200032, China
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ContentType Journal Article
Copyright Copyright © 2018 Jing Yang et al.
COPYRIGHT 2018 John Wiley & Sons, Inc.
Copyright © 2018 Jing Yang et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2018 Jing Yang et al. 2018
Copyright_xml – notice: Copyright © 2018 Jing Yang et al.
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– notice: Copyright © 2018 Jing Yang et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: Copyright © 2018 Jing Yang et al. 2018
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Snippet MicroRNAs play significant roles in the development of cancer and may serve as promising therapeutic targets. In our previous work, miR-219-5p was identified...
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SubjectTerms Analysis
Animal models
Apoptosis
Biology
Biomarkers, Tumor - biosynthesis
Cadherins
Cadherins - biosynthesis
Cancer
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Cell adhesion & migration
Cell cycle
Cell growth
Cell proliferation
Development and progression
E-cadherin
Female
Flow cytometry
Gene Expression Regulation, Neoplastic
Growth
Health aspects
Hep G2 Cells
Hepatocellular carcinoma
Hepatology
Humans
Laboratory animals
Liver cancer
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Male
Manufacturers
Medical prognosis
Medical research
Metastases
Metastasis
MicroRNA
MicroRNAs
MicroRNAs - biosynthesis
miRNA
Multivariate analysis
Neoplasm Metastasis
Neoplasm Proteins - biosynthesis
Patients
Prognosis
Ribonucleic acid
RNA
RNA, Neoplasm - biosynthesis
Therapeutic applications
Tumors
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Title MicroRNA-219-5p Promotes Tumor Growth and Metastasis of Hepatocellular Carcinoma by Regulating Cadherin 1
URI https://search.emarefa.net/detail/BIM-1126910
https://dx.doi.org/10.1155/2018/4793971
https://www.ncbi.nlm.nih.gov/pubmed/29862272
https://www.proquest.com/docview/2045214391
https://www.proquest.com/docview/2049938981
https://pubmed.ncbi.nlm.nih.gov/PMC5976989
Volume 2018
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