MicroRNA-219-5p Promotes Tumor Growth and Metastasis of Hepatocellular Carcinoma by Regulating Cadherin 1

• Published in: BioMed research international Vol. 2018; no. 2018; pp. 1 - 10
• Main Authors: Qin, Lun-Xiu, Jia, Hu-Liang, Zhu, Ying, Gao, Xiao-Mei, Wei, Jin-Wang, Sheng, Yuan-Yuan, Yang, Jing, Dong, Qiong Z.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018; Hindawi; John Wiley & Sons, Inc
• Subjects: Analysis; Animal models; Apoptosis; Biology; Biomarkers, Tumor - biosynthesis; Cadherins; Cadherins - biosynthesis; Cancer; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell adhesion & migration; Cell cycle; Cell growth; Cell proliferation; Development and progression; E-cadherin; Female; Flow cytometry; Gene Expression Regulation, Neoplastic; Growth; Health aspects; Hep G2 Cells; Hepatocellular carcinoma; Hepatology; Humans; Laboratory animals; Liver cancer; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; Manufacturers; Medical prognosis; Medical research; Metastases; Metastasis; MicroRNA; MicroRNAs; MicroRNAs - biosynthesis; miRNA; Multivariate analysis; Neoplasm Metastasis; Neoplasm Proteins - biosynthesis; Patients; Prognosis; Ribonucleic acid; RNA; RNA, Neoplasm - biosynthesis; Therapeutic applications; Tumors; China; United States > US
• ISSN: 2314-6133; 2314-6141; 2314-6141
• DOI: 10.1155/2018/4793971

MicroRNAs play significant roles in the development of cancer and may serve as promising therapeutic targets. In our previous work, miR-219-5p was identified as one of the important metastasis-related microRNAs in HCC. Here we demonstrated that miR-219-5p expression was elevated in HCC tissues and was associated with vascular invasion and dismal prognosis. In multivariate analysis, miR-219-5p was identified as an independent prognostic indicator for HCC patients. Functional mechanism analyses showed that miR-219-5p promoted HCC cell proliferation and invasion in in vitro, as well as in vivo, tumor growth and metastasis in nude mice models bearing human HCC tumors. In addition, cadherin 1 (CDH1) was revealed to be a downstream target of miR-219-5p in HCC cells. In conclusion, miR-219-5p promotes tumor growth and metastasis of HCC by regulating CDH1 and can serve as a prognostic marker for HCC patients.