Domesticated animals as hosts of henipaviruses and filoviruses: A systematic review

• Published in: The veterinary journal (1997) Vol. 233; pp. 25 - 34
• Main Authors: Glennon, Emma E., Restif, Olivier, Sbarbaro, Silke Riesle, Garnier, Romain, Cunningham, Andrew A., Suu-Ire, Richard D., Osei-Amponsah, Richard, Wood, James L.N., Peel, Alison J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2018
• Subjects: Africa; Africa - epidemiology; Animals; Animals, Domestic - virology; Bat-borne viruses; case studies; Chiroptera; Chiroptera - virology; Disease Reservoirs - virology; domestic animals; Domesticated animals; Emerging zoonotic viruses; Filoviridae; Filoviridae Infections - transmission; Filoviridae Infections - veterinary; Filoviruses; Henipavirus; Henipavirus Infections - transmission; Henipavirus Infections - veterinary; Henipaviruses; host-pathogen relationships; hosts; Humans; intensive farming; Nipah henipavirus; risk; systematic review; viruses; zoonoses; Zoonoses - transmission; Zoonoses - virology; Africa; Emerging zoonotic viruses; Bat-borne viruses; Henipaviruses; Domesticated animals; Filoviruses
• ISSN: 1090-0233; 1532-2971; 1532-2971
• DOI: 10.1016/j.tvjl.2017.12.024

•The known roles of domesticated animals in transmission of bat-borne viruses are reviewed.•Knowledge gaps in henipavirus and filovirus epidemiology were identified.•Pigs and horses are the best-studied domesticated hosts of henipaviruses and filoviruses.•The roles of dogs, cats, cattle and poultry in transmission of henipaviruses and filoviruses are not well characterised.•Domesticated animals are especially understudied as hosts of filoviruses in Africa. Bat-borne viruses carry undeniable risks to the health of human beings and animals, and there is growing recognition of the need for a ‘One Health’ approach to understand their frequently complex spill-over routes. While domesticated animals can play central roles in major spill-over events of zoonotic bat-borne viruses, for example during the pig-amplified Malaysian Nipah virus outbreak of 1998-1999, the extent of their potential to act as bridging or amplifying species for these viruses has not been characterised systematically. This review aims to compile current knowledge on the role of domesticated animals as hosts of two types of bat-borne viruses, henipaviruses and filoviruses. A systematic literature search of these virus-host interactions in domesticated animals identified 72 relevant studies, which were categorised by year, location, design and type of evidence generated. The review then focusses on Africa as a case study, comparing research efforts in domesticated animals and bats with the distributions of documented human cases. Major gaps remain in our knowledge of the potential ability of domesticated animals to contract or spread these zoonoses. Closing these gaps will be necessary to fully evaluate and mitigate spill-over risks of these viruses, especially with global agricultural intensification.