Efficacy and safety of sitagliptin as add-on therapy on glycemic control and blood glucose fluctuation in Japanese type 2 diabetes subjects ongoing with multiple daily insulin injections therapy

• Published in: Endocrine Journal Vol. 60; no. 10; pp. 1207 - 1214
• Main Authors: Goto, Rieko, Kondo, Tatsuya, Iwashita, Shinsuke, Maeda, Takako, Araki, Eiichi, Matsuo, Tomoko, Motoshima, Hiroyuki, Furukawa, Noboru, Matsuo, Yasuto, Kawashima, Junji, Ichimori, Shinji, Sekigami, Taiji, Shimoda, Seiya, Nishida, Kenro, Matsumura, Takeshi
• Format: Journal Article
• Language: English
• Published: Japan The Japan Endocrine Society 2013
• Subjects: Aged; Asian Continental Ancestry Group; Blood Glucose - drug effects; Blood Glucose - metabolism; Blood Glucose Self-Monitoring; Body Mass Index; Deoxyglucose - blood; Diabetes Mellitus, Type 2 - drug therapy; Dipeptidyl-Peptidase IV Inhibitors - therapeutic use; Female; Glycated Hemoglobin A - metabolism; Humans; Hypoglycemia; Hypoglycemia - chemically induced; Hypoglycemic Agents - adverse effects; Hypoglycemic Agents - therapeutic use; Insulin - administration & dosage; Insulin - therapeutic use; Male; Middle Aged; Multiple daily insulin injections therapy (MDI); Pyrazines - adverse effects; Pyrazines - therapeutic use; Self-measured plasma glucose (SMPG); Sitagliptin; Sitagliptin Phosphate; Triazoles - adverse effects; Triazoles - therapeutic use; Weight gain
• ISSN: 0918-8959; 1348-4540; 1348-4540
• DOI: 10.1507/endocrj.EJ13-0198

To assess the efficacy and safety of adding sitagliptin, an oral dipeptidyl peptidase-4 inhibitor, in subjects with type 2 diabetes inadequately controlled with multiple daily insulin injections therapy (MDI). HbA1c, 1,5-anhydroglucitol (1,5-AG), body mass index (BMI), insulin doses, six-point self-measured plasma glucose (SMPG) profiles were assessed before, after 12 weeks, and after 24 weeks of MDI with 50 mg/day of sitagliptin in 40 subjects with type 2 diabetes. Safety endpoints included hypoglycemia and any adverse events. HbA1c significantly decreased during the first 12 weeks ( −0.64 ± 0.60 %), and was sustained over 24 weeks ( −0.69 ± 0.85 %). 1,5-AG increased significantly from 7.5 ± 4.5 μg/mL at baseline to 9.6 ± 5.5 μg/mL after 24 weeks. The bolus insulin dose at 12 weeks was decreased, and the mean plasma glucose, the SD of daily glucose, M-value, and the mean amplitude of glycemic excursions (MAGE) also decreased significantly as compared with baseline values. BMI and frequency of hypoglycemia were not changed significantly. Univariate linear regression analyses revealed that % change in HbA1c was significantly associated with BMI, and % changes in the indexes of glycemic instability (SD of daily glucose and MAGE) were significantly associated with age. In conclusion, adding sitagliptin to MDI significantly improved glycemic control and decreased the daily glucose fluctuation in subjects with type 2 diabetes inadequately controlled with MDI, without weight gain or an increase in the incidence of hypoglycemia. This trial was registered with UMIN (no. UMIN000010157).