Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases

• Published in: Biochimica et biophysica acta Vol. 1842; no. 8; pp. 1208 - 1218
• Main Authors: Gan, Li, Johnson, Jeffrey A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2014
• Subjects: Animals; Antioxidant Response Elements - genetics; Humans; Misfolded proteins; Neurodegenerative diseases; Neurodegenerative Diseases - drug therapy; Neurodegenerative Diseases - genetics; Neurodegenerative Diseases - pathology; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; NF-E2-Related Factor 2 - metabolism; Nrf2-ARE pathway; Oxidative stress; Oxidative Stress - drug effects; Oxidative Stress - genetics; Signal Transduction - drug effects; Signal Transduction - genetics; Nrf2-ARE pathway; Oxidative stress; Neurodegenerative diseases; Misfolded proteins
• ISSN: 0925-4439; 0006-3002; 1879-260X
• DOI: 10.1016/j.bbadis.2013.12.011

Oxidative damage contributes to pathogenesis in many neurodegenerative diseases. As the indicator and regulator of oxidative stress, the Nrf2-ARE pathway has been shown dynamic changes and examined for its neuroprotective role in many cases. In this review, we summarize the progress of the Nrf2-ARE pathway in combating toxicity induced from typical misfolded protein aggregates in neurodegenerative diseases, and specifically the effects on the clearance of protein aggregates. This article is part of a Special Issue entitled: Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases. •Oxidative damage in neurodegenerative diseases•Dynamic changes and neuroprotection of the Nrf2-ARE pathway•Effects of the Nrf2-ARE pathway on clearance of misfolded protein aggregates