Regulation of Adipocyte Differentiation via MicroRNAs

Adipocyte differentiation, termed adipogenesis, is a complicated process in which pluripotent mesenchymal stem cells differentiate into mature adipocytes. The process of adipocyte differentiation is tightly regulated by a number of transcription factors, hormones and signaling pathway molecules. Rec...

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Published inEndocrinology and metabolism (Seoul) Vol. 29; no. 2; pp. 122 - 135
Main Authors Son, You Hwa, Ka, Sojeong, Kim, A Young, Kim, Jae Bum
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Endocrine Society 01.06.2014
대한내분비학회
Subjects
Adipocyte differentiation
MicroRNAs
Obesity
Review
내과학
Obesity
MicroRNAs
Adipocyte differentiation
Online AccessGet full text
ISSN2093-596X
2093-5978
DOI10.3803/EnM.2014.29.2.122

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Summary:Adipocyte differentiation, termed adipogenesis, is a complicated process in which pluripotent mesenchymal stem cells differentiate into mature adipocytes. The process of adipocyte differentiation is tightly regulated by a number of transcription factors, hormones and signaling pathway molecules. Recent studies have demonstrated that microRNAs, which belong to small noncoding RNA species, are also involved in adipocyte differentiation. In vivo and in vitro studies have revealed that various microRNAs affect adipogenesis by targeting several adipogenic transcription factors and key signaling molecules. In this review, we will summarize the roles of microRNAs in adipogenesis and their target genes associated with each stage of adipocyte differentiation.
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Current affiliation: Division of Drug Discovery Research, Pharmacological Research Center, Korea Research Institute of Chemical Technology, Daejeon, Korea.
G704-001505.2014.29.2.007
ISSN:2093-596X
2093-5978
DOI:10.3803/EnM.2014.29.2.122