Abnormal premovement gating of somatosensory input in writer's cramp

• Published in: Brain (London, England : 1878) Vol. 123; no. 9; pp. 1813 - 1829
• Main Authors: Murase, Nagako, Kaji, Ryuji, Shimazu, Hideki, Katayama-Hirota, Mari, Ikeda, Akio, Kohara, Nobuo, Kimura, Jun, Shibasaki, Hiroshi, Rothwell, John C.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.09.2000; Oxford Publishing Limited (England)
• Subjects: Adult; Aged; ANOVA = analysis of variance; Biological and medical sciences; CNV = contingent negative variation; Diseases of striated muscles. Neuromuscular diseases; dystonia; Dystonic Disorders - physiopathology; Electromyography; EOG = electro-oculogram; Evoked Potentials, Somatosensory - physiology; Female; Humans; Male; Medical sciences; Middle Aged; Motor Cortex - physiopathology; motor subroutine; Movement - physiology; Neural Pathways - physiopathology; Neurology; Neuropsychological Tests; premovement gating; Psychomotor Performance - physiology; Reaction Time - physiology; SEP = somatosensory evoked potential; Somatosensory Cortex - physiopathology; somatosensory evoked potential; writer's cramp; Human; Nervous system diseases; Pathogenesis; Exploration; Involuntary movement; Electrodiagnosis; Writer cramp; Striated muscle disease; Sensitivity; Body movement; Upper limb; Dystonia; Neurological disorder; Somatosensory evoked potential; Gating; Motricity; Localized; Extrapyramidal syndrome
• ISSN: 0006-8950; 1460-2156; 1460-2156
• DOI: 10.1093/brain/123.9.1813

One characteristic of focal dystonia is the sensory trick, by which sensory input to a certain area of the body can reduce abnormal contractions in muscles nearby. This suggests that adjusting the link between sensory input and movement allows motor commands to be issued more effectively from the brain. To explore this sensorimotor link, we studied the attenuation (gating) of somatosensory evoked potentials (SEPs) before and during hand movements in patients with writer's cramp. For premovement gating, 10 patients and 11 age-matched normal subjects were given a warning sound followed 1s later by an electric stimulus to the right median nerve at the wrist. The latter served both as a reaction signal to start a finger extension task and as the input to evoke SEPs over the scalp. Because reaction times always exceeded 70 ms, short-latency SEPs thus obtained were unaffected by the afferents activated by the movement. The amplitudes of frontal N30 components were significantly decreased over the frontal leads compared with SEPs elicited at rest (P < 0.002) in the normal group, whereas significant gating was found not for N30 but for frontal P22 (P = 0.002) in the patient group. For midmovement gating studies, SEPs to the right median nerve stimulation were recorded in 16 patients and 12 age-matched normal subjects at rest, and during active and passive finger extension–flexion movements. In contrast to the premovement SEPs, the frontal N30 was equally gated during active and passive movements both in the patient (P ≤ 0.002) and the normal group (P ≤ 0.003). These findings indicate that in writer's cramp the sensitivity of sensory input channels from the hand is wrongly set by the central command to move. Perhaps the sensory trick, by supplying additional input not usually present during unobstructed movement, is a manoeuvre to correct this imbalance. Dystonia may result not only from abnormalities in the central motor command but also from disturbed central processing of sensory input.