Sleep-Specific Processing of Auditory Stimuli Is Reflected by Alpha and Sigma Oscillations

• Published in: The Journal of neuroscience Vol. 42; no. 23; pp. 4711 - 4724
• Main Authors: Wislowska, Malgorzata, Klimesch, Wolfgang, Jensen, Ole, Blume, Christine, Schabus, Manuel
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 08.06.2022
• Subjects: Auditory stimuli; Brain; Brain - physiology; Brain research; Cognitive ability; EEG; Electroencephalography; Electroencephalography - methods; Humans; Information processing; Neural networks; NREM sleep; Oscillations; Sensory integration; Sensory perception; Sleep; Sleep - physiology; Sleep and wakefulness; Sleep Stages - physiology; Synchronism; Synchronization; Vigilance; Wakefulness - physiology; information processing; sleep; brain oscillations; EEG; auditory; MEG
• ISSN: 0270-6474; 1529-2401; 1529-2401
• DOI: 10.1523/JNEUROSCI.1889-21.2022

Recent research revealed a surprisingly large range of cognitive operations to be preserved during sleep in humans. The new challenge is therefore to understand functions and mechanisms of processes, which so far have been mainly investigated in awake subjects. The current study focuses on dynamic changes of brain oscillations and connectivity patterns in response to environmental stimulation during non-REM sleep. Our results indicate that aurally presented names were processed and neuronally differentiated across the wake-sleep spectrum. Simultaneously recorded EEG and MEG signals revealed two distinct clusters of oscillatory power increase in response to the stimuli: (1) vigilance state-independent θ synchronization occurring immediately after stimulus onset, followed by (2) sleep-specific α/σ synchronization peaking after stimulus offset. We discuss the possible role of θ, α, and σ oscillations during non-REM sleep, and work toward a unified theory of brain rhythms and their functions during sleep. Previous research has revealed (residual) capacity of the sleeping human brain to interact with the environment. How sensory processing is realized by the neural assemblies in different stages of sleep is however unclear. To tackle this question, we examined simultaneously recorded MEG and EEG data. We discuss the possible role of θ, α, and σ oscillations during non-REM sleep. In contrast to versatile θ band response that reflected early stimulus processing step, succeeding α and σ band activity was sensitive to the saliency of the incoming information, and contingent on the sleep stage. Our findings suggest that the specific reorganization of mechanisms involved in later stages of sensory processing takes place upon falling asleep.