Intestinal microbiota, chronic inflammation, and colorectal cancer

In addition to genetic and epigenetic factors, various environmental factors, including diet, play important roles in the development of colorectal cancer (CRC). Recently, there is increasing interest in the intestinal microbiota as an environmental risk factor for CRC, because diet also influences...

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Bibliographic Details
Published inIntestinal research Vol. 16; no. 3; pp. 338 - 345
Main Authors Park, Chan Hyuk, Eun, Chang Soo, Han, Dong Soo
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Association for the Study of Intestinal Diseases 01.07.2018
대한장연구학회
Subjects
Carcinogenesis
Colorectal neoplasms
Focused Review: Colorectal Cancer
Inflammation
Microbiota
내과학
Microbiota
Inflammation
Colorectal neoplasms
Carcinogenesis
Online AccessGet full text
ISSN1598-9100
2288-1956
DOI10.5217/ir.2018.16.3.338

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Summary:In addition to genetic and epigenetic factors, various environmental factors, including diet, play important roles in the development of colorectal cancer (CRC). Recently, there is increasing interest in the intestinal microbiota as an environmental risk factor for CRC, because diet also influences the composition of the intestinal microbiota. The human intestinal microbiota comprises about 100 trillion microbes. This microbiome thrives on undigested dietary residues in the intestinal lumen and produces various metabolites. It is well known that the dietary risk factors for CRC are mediated by dysbiosis of the intestinal microbiota and their metabolites. In this review, we describe the bacterial taxa associated with CRC, including , enterotoxigenic , , and butyrate-producing bacteria. We also discuss the host-diet interaction in colorectal carcinogenesis.
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ISSN:1598-9100
2288-1956
DOI:10.5217/ir.2018.16.3.338