Prevalence and Risk Factors of Atrophic Gastritis and Intestinal Metaplasia: A Nationwide Multicenter Prospective Study in Korea

• Published in: Gut and liver Vol. 7; no. 3; pp. 303 - 310
• Main Authors: Joo, Young-Eun, Park, Hyun-Kyung, Myung, Dae-Seong, Baik, Gwang-Ho, Shin, Jeong-Eun, SeoⅡ, Geom-Seog, Kim, Gwang Ha, Kim, Heung Up, Kim†, Hyun Young, Cho, Sung-Il, Kim†, Nayoung
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society of Gastroenterology; the Korean Society of Gastrointestinal Endoscopy; the Korean Association for the Study of the Liver; the Korean Society of Neurogastroenterology and Motility; Korean Association for the Study of Intestinal Diseases; Korean College of Helicobacter and Upper Gastrointestinal Research; Korean Pancreatobiliary Association; Korean Society of Gastrointestinal Cancer 01.05.2013; Gastroenterology Council for Gut and Liver; 거트앤리버 소화기연관학회협의회
• Subjects: atrophic gastritis; endoscopy; intestinal metaplasia; Original; prevalence; risk factors; 내과학; Prevalence; Endoscopy; Atrophic gastritis; Intestinal metaplasia; Risk factors
• ISSN: 1976-2283; 2005-1212
• DOI: 10.5009/gnl.2013.7.3.303

Atrophic gastritis (AG) and intestinal metaplasia (IM) are premalignant gastric lesions. The aims of this study were to evaluate the prevalence of endoscopic AG and IM and to document the risk factors for these lesions. In total, 4,023 subjects were enrolled at eight hospitals in Korea. AG and IM were diagnosed by endoscopy. Helicobacter pylori immunoglobulin G antibodies were measured. The prevalences of endoscopic AG and IM were 40.7% and 12.5%. In a multivariate analysis, the risk factors for AG were age groups of 40 to 59 years and >60 years, male sex, positive H. pylori serology, IM, and education below the college level (odds ratio [OR], 2.55, 5.00, 1.38, 1.41, 4.29, and 1.35, respectively). The risk factors for IM were age groups of 40 to 59 years and >60 years, male sex, positive H. pylori serology, AG, having relatives with gastric cancer, education below the college level and consumption of dairy products (OR, 3.16, 3.25, 1.88, 2.17, 3.68, 1.48, 1.47, and 1.40, respectively). A nationwide survey regarding the prevalence of endoscopic AG and IM and their risk factors in Korea supports the hypothesis that endoscopic diagnosis of these premalignant lesions could be helpful to describe a group at high risk for gastric cancer.