Influence of Induction Therapy Using Basiliximab With Delayed Tacrolimus Administration in Heart Transplant Recipients　― Comparison With Standard Tacrolimus-Based Triple Immunosuppression

• Published in: Circulation Journal Vol. 84; no. 12; pp. 2212 - 2223
• Main Authors: Kumai, Yuto, Yoshitake, Koichi, Nakagita, Kazuki, Nakajima, Seiko, Seguchi, Osamu, Matsuda, Sachi, Yajima, Shin, Mochizuki, Hiroki, Ishibashi-Ueda, Hatsue, Matsumoto, Yorihiko, Kakuta, Takashi, Sujino, Yasumori, Fukushima, Norihide, Fujita, Tomoyuki, Takenaka, Hiromi, Yagi, Nobuichiro, Watanabe, Takuya, Ikura, Megumi, Yanase, Masanobu, Kuroda, Kensuke, Fukushima, Satsuki, Anegawa, Eiji, Iwasaki, Keiichiro, Wada, Kyoichi, Hamasaki, Toshimitsu, Toda, Koichi, Kobayashi, Junjiro, Kimura, Yuki, Tadokoro, Naoki
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 25.11.2020
• Subjects: Basiliximab; Basiliximab - therapeutic use; Graft Rejection - prevention & control; Heart Transplantation; High-risk heart transplant; Humans; Immunosuppression Therapy; Immunosuppressive Agents - therapeutic use; Induction Chemotherapy; Induction therapy; Kidney Diseases - drug therapy; Retrospective Studies; Tacrolimus - therapeutic use; Basiliximab; Induction therapy; High-risk heart transplant
• ISSN: 1346-9843; 1347-4820; 1347-4820
• DOI: 10.1253/circj.CJ-20-0164

Background:Appropriate indications and protocols for induction therapy using basiliximab have not been fully established in heart transplant (HTx) recipients. This study elucidated the influence of induction therapy using basiliximab along with delayed tacrolimus (Tac) initiation on the outcomes of high-risk HTx recipients.Methods and Results:A total of 86 HTx recipients treated with Tac-based immunosuppression were retrospectively reviewed. Induction therapy was administered to 46 recipients (53.5%) with impaired renal function, pre-transplant sensitization, and recipient- and donor-related risk factors (Induction group). Tac administration was delayed in the Induction group. Induction group subjects showed a lower cumulative incidence of acute cellular rejection grade ≥1R after propensity score adjustment, but this was not significantly different (hazard ratio [HR]: 0.63, 95% confidence interval [CI]: 0.37–1.08, P=0.093). Renal dysfunction in the Induction group significantly improved 6 months post-transplantation (P=0.029). The cumulative incidence of bacterial or fungal infections was significantly higher in the Induction group (HR: 10.6, 95% CI: 1.28–88.2, P=0.029).Conclusions:These results suggest that basiliximab-based induction therapy with delayed Tac initiation may suppress mild acute cellular rejection and improve renal function in recipients with renal dysfunction, resulting in its non-inferior outcome, even in high-risk patients, when applied to the appropriate recipients. However, it should be carefully considered in recipients at a high risk of bacterial and fungal infections.