Microbiota in interstitial cystitis/bladder pain syndrome: evidence and opportunities

Urologic chronic pelvic pain syndrome (UCPPS) and interstitial cystitis/bladder pain syndrome (IC/BPS) are associated with dysbiosis of the gut and possibly other compartments. Future studies are needed to more definitively determine whether these associations are causally linked to pathogenesis. Me...

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Bibliographic Details
Published inThe Journal of clinical investigation Vol. 135; no. 17; pp. 1 - 4
Main Author Klumpp, David J.
Format Journal Article
LanguageEnglish
Published United States American Society for Clinical Investigation 15.09.2025
Subjects
Biomarkers
Bladder
Chronic pain
Comorbidity
Cystitis
Dysbacteriosis
Fatty acids
Females
Gut microbiota
Intestinal microflora
Medical colleges
Metabolism
Metabolites
Microbiota
Microbiota (Symbiotic organisms)
Patients
Pelvis
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ISSN1558-8238
0021-9738
1558-8238
DOI10.1172/JCI197858

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Summary:Urologic chronic pelvic pain syndrome (UCPPS) and interstitial cystitis/bladder pain syndrome (IC/BPS) are associated with dysbiosis of the gut and possibly other compartments. Future studies are needed to more definitively determine whether these associations are causally linked to pathogenesis. Mechanisms of visceral convergence that mediate organ crosstalk as well as circulating factors endow gut microbiota with the potential to modulate IC symptoms peripherally and centrally. By targeting the effects of dysbiosis directly and indirectly, microbiota thus offer unique therapeutic opportunities to potentially treat pelvic pain and comorbid conditions of IC.
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ISSN:1558-8238
0021-9738
1558-8238
DOI:10.1172/JCI197858