Periodontal pathogens and obesity in the context of cardiovascular risks across age groups

• Published in: Frontiers in oral health Vol. 5; p. 1488833
• Main Authors: Leonov, Georgy, Varaeva, Yurgita, Livantsova, Elena, Vasilyev, Andrey, Vladimirskaya, Olga, Korotkova, Tatyana, Nikityuk, Dmitry, Starodubova, Antonina
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media SA 09.01.2025; Frontiers Media S.A
• Subjects: Age; Bacteria; Biofilms; biomarkers; Body fat; Body mass index; Cardiovascular disease; Cytokines; Diabetes; Food safety; Gum disease; Heart attacks; High density lipoprotein; Hypertension; Inflammation; Lipids; Metabolic disorders; Metabolites; Microbiota; Microorganisms; Mortality; Nutrition; Obesity; Oral Health; P. gingivalis; Pathogens; periodontal pathogens; Questionnaires; Risk factors; United States > US; Russia; P. gingivalis; cardiovascular disease; periodontal pathogens; biomarkers; obesity
• ISSN: 2673-4842; 2673-4842
• DOI: 10.3389/froh.2024.1488833

Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity among noncommunicable diseases. Over the past decade, there has been a notable increase in the prevalence of CVDs among young individuals. Obesity, a well-known risk factor for CVDs, is also associated with various comorbidities that may contribute to cardiovascular risk. The relationship between periodontal pathogens and CVD risk factors, including obesity, smoking, lipid metabolism disorders, and inflammatory markers, remains underexplored. This study examined the relationship between six periodontal pathogens ( ) and CVD risk factors among 189 subjects stratified by age and body mass index (BMI). Body composition was assessed via bioimpedance analysis, and blood samples were analyzed for lipid profiles, glucose, and proinflammatory cytokines. Oral samples were collected for polymerase chain reaction (PCR) analysis to identify periodontal pathogens. Cardiovascular and diabetes risk scores were calculated using the SCORE and FINDRISC scales. The prevalence of periodontal pathogens in the population was 33.0% for , 47.8% for , 63.4% for , 46.6% for , 46.6% for , and 89.2% for . Significant age- and BMI-related differences were observed in pathogen prevalence, particularly with , , and . Young obese individuals exhibited a higher prevalence of and . was found to be associated with hypertension and dyslipidemia, while was linked to hypertension and obesity. was associated with obesity, dyslipidemia and smoking, whereas was linked to dyslipidemia alone. This study highlights the potential connection between periodontal pathogens and risk factors associated with cardiovascular disease, including smoking, elevated BMI, increased adipose tissue, hypertension, and dyslipidemia. Further research is required to determine the causal relationships between oral microbiome dysbiosis, obesity and, systemic diseases and to develop an effective strategy for preventing oral health-related CVD risk factors in young adults.