Protective effects of citrus based mixture drinks (CBMDs) on oxidative stress and restraint stress

• Published in: Food science and biotechnology Vol. 27; no. 6; pp. 1801 - 1809
• Main Authors: Cho, MyoungLae, Kim, Dan-Bi, Shin, Gi-Hae, Kim, Jae-Min, Seo, Yoonhee, Choe, Soo Young, Cho, Ju Hyun, Kim, Young-Cheul, Lee, Jin-Ha, Lee, Ok-Hwan
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.12.2018; Springer Nature B.V; 한국식품과학회
• Subjects: Beverages; Bioflavonoids; cell viability; Chemistry; Chemistry and Materials Science; Citrus; Constraints; Electrodes; exercise test; fibroblasts; Food Science; hesperidin; humans; Hydrogen peroxide; Nutrition; Oxidative stress; protective effect; Rats; Skin; 식품과학; Narirutin; Oxidative stress; Restraint stress; Citrus based mixture drinks; Hesperidin
• ISSN: 1226-7708; 2092-6456; 2092-6456
• DOI: 10.1007/s10068-018-0396-z

In the current study investigated the protective effects of citrus based mixture drinks (CBMDs) using oxidative stress in human dermal fibroblast (HDF) cells and restraint-stressed rats. The CBMDs contained citrus bioflavonoids including narirutin and hesperidin. The cell viability of HDF cells treated with H 2 O 2 was observed at 53.9% but treated with CBMD-1 and CBMD-2 (500 μg/mL) on H 2 O 2 exposed HDF cells significantly increased the relative cell viability at 65.0 and 72.2%, respectively. In the treadmill test, the time spent on the electrode plate in the restraint-stressed group was analyzed 24.1 s, but restraint-stressed rats with administered CBMDs (300 mg/kg) had significantly decreased the time at 2.4 (CBMD-1) and 4.7 (CBMD-2) s, respectively. In addition, number of touches the electrode plate in restraint-stressed group was observed at 42.4 ea, but, restraint-stressed rats with administered CBMD-1 and CBMD-2 (300 mg/kg) were significantly decreased at 7.0 and 10.2 ea, respectively.