Hydrogen Sulfide Biology and Its Role in Cancer

Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian tissues. It plays a very critical role in many pathophysiological processes in the body. It can be endogenously produced through many enzymes analogous to the cysteine family, while the exogenous source may involve...

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Published inMolecules (Basel, Switzerland) Vol. 27; no. 11; p. 3389
Main Authors Khattak, Saadullah, Rauf, Mohd Ahmar, Khan, Nazeer Hussain, Zhang, Qian-Qian, Chen, Hao-Jie, Muhammad, Pir, Ansari, Mohammad Azam, Alomary, Mohammad N., Jahangir, Muhammad, Zhang, Chun-Yang, Ji, Xin-Ying, Wu, Dong-Dong
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 25.05.2022
MDPI
Subjects
Angiogenesis
Animals
Biology
Biosynthesis
Brain research
Cancer
Cardiovascular system
Cell cycle
Colorectal cancer
Cysteine
DNA repair
endogenous gases
Enzymes
Glucose
Homocysteine
hydrogen sulfide
Hydrogen Sulfide - metabolism
Kidneys
Liver
Lungs
Mammals
Mammals - metabolism
Metabolism
Metastasis
Microbiota
Mitochondria
Neoplasms - drug therapy
Nervous system
Physiology
Review
Roles
Signal Transduction - physiology
signaling pathways
Small intestine
Sulfur
translational medicine
Uterus
endogenous gases
translational medicine
cancer
signaling pathways
hydrogen sulfide
Online AccessGet full text
ISSN1420-3049
1420-3049
DOI10.3390/molecules27113389

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Abstract Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian tissues. It plays a very critical role in many pathophysiological processes in the body. It can be endogenously produced through many enzymes analogous to the cysteine family, while the exogenous source may involve inorganic sulfide salts. H2S has recently been well investigated with regard to the onset of various carcinogenic diseases such as lung, breast, ovaries, colon cancer, and neurodegenerative disorders. H2S is considered an oncogenic gas, and a potential therapeutic target for treating and diagnosing cancers, due to its role in mediating the development of tumorigenesis. Here in this review, an in-detail up-to-date explanation of the potential role of H2S in different malignancies has been reported. The study summarizes the synthesis of H2S, its roles, signaling routes, expressions, and H2S release in various malignancies. Considering the critical importance of this active biological molecule, we believe this review in this esteemed journal will highlight the oncogenic role of H2S in the scientific community.
AbstractList Hydrogen sulfide (H S) is an endogenous biologically active gas produced in mammalian tissues. It plays a very critical role in many pathophysiological processes in the body. It can be endogenously produced through many enzymes analogous to the cysteine family, while the exogenous source may involve inorganic sulfide salts. H S has recently been well investigated with regard to the onset of various carcinogenic diseases such as lung, breast, ovaries, colon cancer, and neurodegenerative disorders. H S is considered an oncogenic gas, and a potential therapeutic target for treating and diagnosing cancers, due to its role in mediating the development of tumorigenesis. Here in this review, an in-detail up-to-date explanation of the potential role of H S in different malignancies has been reported. The study summarizes the synthesis of H S, its roles, signaling routes, expressions, and H S release in various malignancies. Considering the critical importance of this active biological molecule, we believe this review in this esteemed journal will highlight the oncogenic role of H S in the scientific community.
Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian tissues. It plays a very critical role in many pathophysiological processes in the body. It can be endogenously produced through many enzymes analogous to the cysteine family, while the exogenous source may involve inorganic sulfide salts. H2S has recently been well investigated with regard to the onset of various carcinogenic diseases such as lung, breast, ovaries, colon cancer, and neurodegenerative disorders. H2S is considered an oncogenic gas, and a potential therapeutic target for treating and diagnosing cancers, due to its role in mediating the development of tumorigenesis. Here in this review, an in-detail up-to-date explanation of the potential role of H2S in different malignancies has been reported. The study summarizes the synthesis of H2S, its roles, signaling routes, expressions, and H2S release in various malignancies. Considering the critical importance of this active biological molecule, we believe this review in this esteemed journal will highlight the oncogenic role of H2S in the scientific community.
Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian tissues. It plays a very critical role in many pathophysiological processes in the body. It can be endogenously produced through many enzymes analogous to the cysteine family, while the exogenous source may involve inorganic sulfide salts. H2S has recently been well investigated with regard to the onset of various carcinogenic diseases such as lung, breast, ovaries, colon cancer, and neurodegenerative disorders. H2S is considered an oncogenic gas, and a potential therapeutic target for treating and diagnosing cancers, due to its role in mediating the development of tumorigenesis. Here in this review, an in-detail up-to-date explanation of the potential role of H2S in different malignancies has been reported. The study summarizes the synthesis of H2S, its roles, signaling routes, expressions, and H2S release in various malignancies. Considering the critical importance of this active biological molecule, we believe this review in this esteemed journal will highlight the oncogenic role of H2S in the scientific community.Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian tissues. It plays a very critical role in many pathophysiological processes in the body. It can be endogenously produced through many enzymes analogous to the cysteine family, while the exogenous source may involve inorganic sulfide salts. H2S has recently been well investigated with regard to the onset of various carcinogenic diseases such as lung, breast, ovaries, colon cancer, and neurodegenerative disorders. H2S is considered an oncogenic gas, and a potential therapeutic target for treating and diagnosing cancers, due to its role in mediating the development of tumorigenesis. Here in this review, an in-detail up-to-date explanation of the potential role of H2S in different malignancies has been reported. The study summarizes the synthesis of H2S, its roles, signaling routes, expressions, and H2S release in various malignancies. Considering the critical importance of this active biological molecule, we believe this review in this esteemed journal will highlight the oncogenic role of H2S in the scientific community.
Hydrogen sulfide (H 2 S) is an endogenous biologically active gas produced in mammalian tissues. It plays a very critical role in many pathophysiological processes in the body. It can be endogenously produced through many enzymes analogous to the cysteine family, while the exogenous source may involve inorganic sulfide salts. H 2 S has recently been well investigated with regard to the onset of various carcinogenic diseases such as lung, breast, ovaries, colon cancer, and neurodegenerative disorders. H 2 S is considered an oncogenic gas, and a potential therapeutic target for treating and diagnosing cancers, due to its role in mediating the development of tumorigenesis. Here in this review, an in-detail up-to-date explanation of the potential role of H 2 S in different malignancies has been reported. The study summarizes the synthesis of H 2 S, its roles, signaling routes, expressions, and H 2 S release in various malignancies. Considering the critical importance of this active biological molecule, we believe this review in this esteemed journal will highlight the oncogenic role of H 2 S in the scientific community.
Author Rauf, Mohd Ahmar
Khattak, Saadullah
Zhang, Qian-Qian
Jahangir, Muhammad
Wu, Dong-Dong
Muhammad, Pir
Khan, Nazeer Hussain
Chen, Hao-Jie
Ansari, Mohammad Azam
Alomary, Mohammad N.
Zhang, Chun-Yang
Ji, Xin-Ying
AuthorAffiliation 5 National Centre for Biotechnology, King Abdulaziz City for Science and Technology (KACST), P.O. Box 6086, Riyadh 11442, Saudi Arabia; malomary@kacst.edu.sa
1 Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China; saadullah@henu.edu.cn (S.K.); kakakhan3514@gmail.com (N.H.K.); 13323950805@163.com (Q.-Q.Z.); chj104753201139@henu.edu.cn (H.-J.C.)
6 Department of Psychiatric and Mental Health, Central South University, Changsha 410078, China; jahangir.masoom@csu.edu.cn
9 Kaifeng Key Laboratory of Infection and Biological Safety, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China
10 School of Stomatology, Henan University, Kaifeng 475004, China
2 Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; mxr2481@med.miami.edu
7 Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
4 Department of
AuthorAffiliation_xml – name: 7 Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
– name: 2 Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; mxr2481@med.miami.edu
– name: 4 Department of Epidemic Disease Research, Institute for Research & Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia; maansari@iau.edu.sa
– name: 5 National Centre for Biotechnology, King Abdulaziz City for Science and Technology (KACST), P.O. Box 6086, Riyadh 11442, Saudi Arabia; malomary@kacst.edu.sa
– name: 6 Department of Psychiatric and Mental Health, Central South University, Changsha 410078, China; jahangir.masoom@csu.edu.cn
– name: 9 Kaifeng Key Laboratory of Infection and Biological Safety, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China
– name: 10 School of Stomatology, Henan University, Kaifeng 475004, China
– name: 1 Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China; saadullah@henu.edu.cn (S.K.); kakakhan3514@gmail.com (N.H.K.); 13323950805@163.com (Q.-Q.Z.); chj104753201139@henu.edu.cn (H.-J.C.)
– name: 8 Department of General Thoracic Surgery, Hami Central Hospital, Hami 839000, China
– name: 3 Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng 475004, China; pir@henu.edu.cn
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  givenname: Saadullah
  surname: Khattak
  fullname: Khattak, Saadullah
– sequence: 2
  givenname: Mohd Ahmar
  surname: Rauf
  fullname: Rauf, Mohd Ahmar
– sequence: 3
  givenname: Nazeer Hussain
  orcidid: 0000-0003-4380-233X
  surname: Khan
  fullname: Khan, Nazeer Hussain
– sequence: 4
  givenname: Qian-Qian
  surname: Zhang
  fullname: Zhang, Qian-Qian
– sequence: 5
  givenname: Hao-Jie
  surname: Chen
  fullname: Chen, Hao-Jie
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  orcidid: 0000-0001-5960-0279
  surname: Muhammad
  fullname: Muhammad, Pir
– sequence: 7
  givenname: Mohammad Azam
  surname: Ansari
  fullname: Ansari, Mohammad Azam
– sequence: 8
  givenname: Mohammad N.
  surname: Alomary
  fullname: Alomary, Mohammad N.
– sequence: 9
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  orcidid: 0000-0002-7364-9228
  surname: Jahangir
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– sequence: 10
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  fullname: Zhang, Chun-Yang
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  givenname: Xin-Ying
  surname: Ji
  fullname: Ji, Xin-Ying
– sequence: 12
  givenname: Dong-Dong
  orcidid: 0000-0001-6739-8437
  surname: Wu
  fullname: Wu, Dong-Dong
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35684331$$D View this record in MEDLINE/PubMed
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Cites_doi 10.3390/ijms22042194
10.1007/s00018-016-2406-8
10.1002/jor.21350
10.7314/APJCP.2013.14.4.2607
10.1016/S0002-9440(10)63645-0
10.1089/dna.2019.5067
10.1016/j.phrs.2016.08.026
10.1007/s00280-014-2655-x
10.1016/j.ejphar.2011.01.052
10.4103/jcrt.JCRT_423_17
10.7150/jca.35375
10.1038/nrc2602
10.1111/apt.15088
10.1016/j.bbamcr.2014.08.005
10.1016/j.mito.2016.06.006
10.2174/157488411797189442
10.1093/annonc/mds249
10.1017/S0007114509992492
10.1002/ijc.28715
10.1016/j.urology.2011.10.013
10.1186/1476-4598-10-68
10.3390/biom9120839
10.1016/j.redox.2019.101190
10.1158/0008-5472.CAN-15-1544
10.1155/2019/2360945
10.1016/j.bone.2021.116168
10.1371/journal.pone.0079167
10.1016/j.fct.2016.09.028
10.1038/s41420-021-00553-6
10.1155/2016/6043038
10.1038/s41467-018-03899-1
10.1371/journal.pone.0122062
10.1016/j.phrs.2018.11.034
10.1158/0008-5472.CAN-11-3115
10.1073/pnas.0705710104
10.3892/ijo.2015.2914
10.1016/bs.enz.2015.05.003
10.1080/10715762.2018.1431626
10.5114/hpc.2020.96571
10.1155/2015/186908
10.3389/fgene.2021.706814
10.1016/j.freeradbiomed.2012.04.007
10.1016/j.phrs.2020.105119
10.1002/jnr.23925
10.1016/j.gie.2015.11.031
10.1016/j.yexcr.2014.09.027
10.1089/ars.2013.5308
10.1089/ars.2021.0203
10.1159/000521671
10.1038/nature03482
10.1158/1055-9965.EPI-08-0710
10.1021/acs.jmedchem.5b01033
10.1002/ptr.6586
10.1016/j.neuint.2010.01.004
10.1158/1078-0432.CCR-06-2074
10.2165/11318550-000000000-00000
10.1093/jnci/djm135
10.1080/01635581.2014.868912
10.15252/embr.201845986
10.7150/ijms.36516
10.1016/j.clgc.2014.11.001
10.1038/35077213
10.1096/fj.02-0211hyp
10.1155/2019/6927298
10.1186/1476-4598-9-47
10.3892/or.2016.4691
10.1038/srep36125
10.1038/ncomms2623
10.1016/j.ejphar.2008.07.029
10.1002/embr.201338213
10.1038/nrm3629
10.3390/biom11050682
10.1038/cddis.2014.495
10.3390/nano12020258
10.1371/journal.pone.0021077
10.1016/j.redox.2021.101926
10.5414/CP201937
10.1002/ijc.23131
10.1074/jbc.M116.746339
10.1161/CIRCULATIONAHA.112.000855
10.1016/j.cellsig.2012.02.003
10.1111/bcp.12907
10.1016/j.cardiores.2007.05.026
10.1074/jbc.R110.128363
10.1517/14656566.2012.647406
10.1016/j.bcp.2017.10.011
10.1038/nrd2425
10.1074/jbc.M310211200
10.18632/oncotarget.3026
10.1038/bjc.2014.564
10.1016/j.phrs.2018.03.002
10.1002/ejp.798
10.3390/ijms22179271
10.1002/tox.20737
10.1074/jbc.M802529200
10.1002/ptr.6159
10.1093/annonc/mdv244
10.1093/carcin/bgh149
10.1158/1078-0432.CCR-08-0141
10.1038/pcan.2011.49
10.1093/carcin/bgi272
10.1089/ars.2012.4612
10.1073/pnas.1308487110
10.1016/j.leukres.2009.01.030
10.7555/JBR.28.20140037
10.1038/nrc3110
10.1136/gutjnl-2011-300721
10.1016/j.redox.2020.101772
10.1155/2012/718320
10.1074/jbc.M114.605733
10.1016/j.dnarep.2018.11.002
10.1039/C6SC05646F
10.1159/000441520
10.1053/j.gastro.2009.04.012
10.1089/ars.2010.3678
10.1074/jbc.M808026200
10.1016/j.critrevonc.2017.09.016
10.1016/j.heliyon.2019.e02244
10.1002/(SICI)1097-010X(19981015)282:3<310::AID-JEZ4>3.0.CO;2-P
10.1089/ars.2012.5041
10.1371/journal.pone.0037572
10.3892/ijo.2014.2305
10.1016/j.freeradbiomed.2015.05.024
10.1016/j.cllc.2015.04.008
10.1016/j.mrfmmm.2006.01.007
10.1039/C6CS00212A
10.1074/jbc.M408997200
10.1158/1535-7163.MCT-06-0494
10.1158/1535-7163.MCT-18-0695
10.3390/nu11020295
10.1016/j.pharep.2015.01.005
10.1186/s12885-018-4508-1
10.1016/j.redox.2020.101675
10.1002/gcc.22115
10.1007/s00520-008-0409-1
10.1089/ars.2013.5324
10.1016/j.molimm.2021.12.003
10.1016/j.bcp.2012.10.019
10.1200/JCO.2005.01.5594
10.1186/s12951-021-01069-y
10.1021/jf204193v
10.1158/1078-0432.CCR-09-1980
10.1007/s00726-010-0510-x
10.1074/jbc.M802330200
10.1074/jbc.M110.115261
10.1038/s41598-017-05457-z
10.1002/mc.20258
10.1038/nrmicro3184
10.3390/pathophysiology28030028
10.3892/or.2015.4292
10.1016/j.mrfmmm.2014.03.002
10.1089/ars.2009.3074
10.1002/jat.3734
10.1016/j.currproblcancer.2017.05.002
10.1002/cam4.286
10.1016/j.mvr.2013.09.002
10.1038/aps.2013.127
10.1007/s00280-012-2025-5
10.1055/s-0034-1398544
10.7314/APJCP.2014.15.19.8225
10.1038/sj.onc.1205868
10.1007/s00726-010-0606-3
10.1016/j.biomaterials.2021.121103
10.1016/j.cell.2012.03.042
10.1016/j.neo.2021.03.009
10.1016/j.molonc.2014.10.013
10.1021/ja1085723
10.1016/S1470-2045(19)30272-4
10.1515/hsz-2015-0148
10.1634/theoncologist.2018-0377
10.1016/j.ejca.2018.10.002
10.1007/978-3-319-18144-8_13
10.1089/ars.2012.4645
10.3389/fphar.2017.00763
10.1021/bc500150s
10.1016/S0166-2236(96)01035-1
10.1016/j.bcp.2020.114267
10.1089/ars.2009.2899
10.1038/srep40070
10.1038/s41598-017-00557-2
10.1016/j.freeradbiomed.2010.02.014
10.3892/ijo.2017.4084
10.3389/fcell.2022.829316
10.1016/j.niox.2013.07.002
10.1038/bjc.2012.154
10.1016/j.bbrc.2007.05.063
10.1038/cddis.2017.18
10.1152/physrev.00017.2011
10.1586/17512433.2013.842126
10.1515/cclm-2013-0069
10.1590/1414-431x20198409
10.1089/ars.2019.7841
10.1007/s10549-010-1299-8
10.1016/S0140-6736(16)32453-9
10.1007/s40487-016-0027-x
10.1002/ptr.6278
10.3390/molecules23112966
10.1038/s41419-020-2298-2
10.1002/tox.22841
10.1158/0008-5472.CAN-04-1326
10.1089/ars.2008.2282
10.1200/JCO.2017.35.15_suppl.3551
10.1200/JCO.2011.37.1195
10.1111/j.1365-2710.2012.01342.x
10.1093/biolre/ioz027
10.1038/aps.2016.146
10.1016/j.bbi.2010.09.001
10.3892/ijo.2012.1640
10.1269/jrr.11004
10.1016/j.cellsig.2020.109870
10.1016/j.clcc.2018.11.002
10.3390/cells8080828
10.1016/j.bcp.2019.113775
10.1016/j.bbrc.2016.03.154
10.1073/pnas.0908047106
10.1016/j.neures.2009.09.1713
10.1016/j.brainres.2012.10.046
10.1007/s11030-022-10406-8
10.2214/AJR.12.9049
10.4158/EP171822.OR
10.1007/s11064-015-1784-x
10.1002/tox.22581
10.1089/ars.2009.2947
10.1016/j.freeradbiomed.2009.04.014
10.1016/j.molcel.2011.10.021
10.3168/jds.S0022-0302(05)73126-X
10.1007/s00280-015-2899-0
10.1016/j.taap.2011.09.026
10.1016/j.lfs.2021.119551
10.1016/S0140-6736(12)61900-X
10.1371/journal.pone.0022486
10.3390/cells10020220
10.1016/j.fitote.2016.02.007
10.1016/j.ctrv.2012.09.004
10.1074/jbc.M110.132142
10.21873/anticanres.12668
10.1177/1758835920982853
10.7150/ijbs.47850
10.3389/fonc.2020.00252
10.1186/s12885-021-07833-5
10.1016/S1569-9056(16)60046-5
10.3892/mmr.2014.2161
10.1158/0008-5472.CAN-04-1554
10.1038/nrclinonc.2012.59
10.1016/j.bcp.2017.11.014
10.1038/nrd4433
10.1634/theoncologist.2013-0059
10.21873/anticanres.12839
10.1007/978-3-319-18144-8_12
10.1371/journal.pone.0049683
10.1093/carcin/bgi265
10.1038/s41598-017-11256-3
10.1016/0020-711X(93)90496-2
10.1371/journal.pone.0020525
10.1007/s00280-013-2339-y
10.1002/em.20454
10.1007/s12012-012-9164-0
10.1021/ac302409a
10.1016/j.niox.2015.08.004
10.1016/j.hfc.2011.03.004
10.1016/S1470-2045(15)70156-7
10.1097/MD.0000000000014774
10.3389/fphar.2016.00385
10.18632/oncotarget.6482
10.3390/biology10020083
10.1016/j.atherosclerosis.2017.08.012
10.1161/CIRCULATIONAHA.107.753467
10.1093/jn/134.8.2004
10.3390/biom10020323
10.1023/B:APPT.0000045801.15585.dd
10.3892/or.2016.5014
10.3390/biom11060896
10.1093/carcin/bgq267
10.1016/j.freeradbiomed.2013.02.024
10.3892/ol.2021.12918
10.1089/ars.2009.2882
10.1007/BF02170255
10.1093/jn/134.9.2229
10.1089/ars.2010.3525
10.1016/j.redox.2020.101564
10.1007/978-3-030-34025-4_17
10.1007/s11064-018-2471-5
10.1016/j.cellsig.2014.08.023
10.1126/scisignal.2000464
10.1002/wsbm.1331
10.3892/or.2015.4248
10.1074/jbc.M111.270884
10.1002/ddr.430340203
10.1111/bph.14100
10.1038/nrc3237
10.3390/biom10030447
10.1096/fj.06-7407com
10.1146/annurev-pharmtox-010510-100505
10.1007/978-3-319-18144-8_1
10.1111/pcmr.12312
10.1038/nature11706
10.3389/fphar.2020.564281
10.1016/j.bcp.2017.10.007
10.1002/ijc.25922
10.1096/fj.12-216507
10.1089/ars.2013.5309
10.1016/j.jamcollsurg.2014.07.315
10.1038/nrc2663
10.1371/journal.pone.0025799
10.1089/ars.2011.4005
10.3892/or.2021.8019
10.1074/jbc.RA119.009442
10.18632/oncotarget.12407
10.1016/j.tips.2007.09.003
10.1089/jop.2015.0144
10.1016/j.redox.2022.102233
10.1007/s12094-021-02669-8
10.1016/bs.mie.2014.11.036
10.1016/j.lfs.2020.118348
10.1155/2015/691070
10.3109/09637481003639092
10.3390/molecules191221350
10.3390/cells11030325
10.1038/s12276-019-0216-4
10.1038/s41598-021-88355-9
10.1016/j.ecoenv.2020.110464
10.1161/CIRCRESAHA.111.240242
10.1096/fj.201701095R
10.1002/hep.29515
10.1016/j.cell.2011.02.013
10.1038/nrd.2015.1
10.1016/j.wneu.2017.08.017
10.1002/glia.20905
10.1158/1541-7786.MCR-14-0184
10.1073/pnas.1306241110
10.1186/1756-8722-1-6
10.3390/ijms22168898
10.1039/C8SC03781G
10.1158/1078-0432.CCR-07-5270
10.1016/j.jhep.2014.03.030
10.1161/CIRCRESAHA.114.300505
10.3892/or.2016.4577
10.1038/ki.2011.288
10.1016/j.niox.2014.05.014
10.1038/cddis.2013.41
10.1038/sj.onc.1208656
10.1016/j.ejcsup.2013.07.016
10.1152/ajpcell.00021.2015
10.1042/CBI20090368
10.59566/IJBS.2012.8081
10.1200/JCO.2018.36.4_suppl.412
10.1016/j.canlet.2019.04.031
10.3748/wjg.v11.i26.3990
10.1007/978-3-319-18144-8_10
10.3390/biom10040653
10.1089/ars.2017.7058
10.1111/odi.12223
10.1016/j.phrs.2020.105393
10.1371/journal.pone.0101145
10.1038/s41419-018-1063-2
10.1158/1535-7163.MCT-06-0396
10.3389/fphar.2018.01066
10.1159/000492464
10.1158/1940-6207.CAPR-10-0048
10.1016/j.yexcr.2013.10.023
10.1016/j.freeradbiomed.2017.01.026
10.1126/science.1162667
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Keywords endogenous gases
translational medicine
cancer
signaling pathways
hydrogen sulfide
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References Wahafu (ref_120) 2018; 15
Karim (ref_84) 2020; 182
Li (ref_223) 2022; 141
Hwang (ref_260) 2010; 61
ref_254
Kim (ref_280) 2006; 27
Bentke (ref_115) 2017; 64
Jurkowska (ref_114) 2011; 41
Sen (ref_143) 2012; 45
Mi (ref_270) 2008; 283
Kondo (ref_51) 2013; 127
Mousa (ref_340) 2010; 24
Zhu (ref_313) 2014; 15
Guo (ref_90) 2012; 79
ref_129
Ma (ref_305) 2018; 39
Busquet (ref_237) 2005; 88
Lee (ref_167) 2007; 358
Schwartz (ref_146) 2005; 23
Wang (ref_266) 2007; 46
Bryant (ref_273) 2010; 9
Huang (ref_282) 2012; 60
Cella (ref_359) 2014; 3
Zhang (ref_203) 2017; 8
Grothey (ref_333) 2017; 35
Switzer (ref_233) 2012; 72
Adenis (ref_335) 2016; 16
Lee (ref_274) 2015; 34
ref_159
Webb (ref_165) 2011; 11
ref_151
Kandula (ref_355) 2011; 80
Xiao (ref_257) 2006; 5
Kim (ref_304) 2010; 32
Mao (ref_30) 2020; 10
Mani (ref_62) 2014; 20
ref_156
Jackson (ref_272) 2004; 134
Cotter (ref_178) 2009; 9
Bates (ref_14) 2015; 10
ref_160
Zhen (ref_141) 2015; 46
Smith (ref_271) 2004; 25
ref_268
Wang (ref_224) 2018; 9
Wu (ref_61) 2019; 2019
Hansel (ref_92) 2003; 163
Lucarini (ref_173) 2018; 32
Zhu (ref_289) 2016; 7
Xu (ref_184) 2018; 11
ref_387
Wang (ref_24) 2002; 16
Mazhar (ref_210) 2021; 7
Wu (ref_137) 2017; 7
Parsanathan (ref_220) 2018; 52
Untereiner (ref_118) 2018; 149
Vanneman (ref_321) 2012; 12
Yang (ref_144) 2013; 18
ref_214
ref_334
ref_218
ref_339
Xu (ref_310) 2020; 34
Bruix (ref_331) 2017; 389
ref_212
Giustarini (ref_380) 2010; 48
Zhao (ref_41) 2015; 58
Wang (ref_217) 2021; 278
Kim (ref_303) 2010; 130
Cornell (ref_320) 2012; 37
Myzak (ref_264) 2004; 64
Rosenbaum (ref_326) 2008; 16
Dong (ref_5) 2019; 455
ref_324
ref_205
Pan (ref_225) 2021; 19
Xiao (ref_277) 2008; 283
ref_209
Abramson (ref_354) 2013; 200
Kandil (ref_106) 2010; 56
Li (ref_72) 2011; 51
Lee (ref_245) 2010; 58
ref_201
Francia (ref_145) 2014; 12
Qi (ref_349) 2012; 71
Manna (ref_183) 2011; 286
Polhemus (ref_55) 2014; 114
Chen (ref_258) 2012; 2012
ref_119
Rajendran (ref_263) 2011; 10
Shen (ref_60) 2012; 52
Li (ref_152) 2020; 34
Rose (ref_140) 2005; 11
Rajan (ref_297) 2016; 110
Hasan (ref_389) 2019; 51
Svoboda (ref_346) 2012; 12
Kashfi (ref_52) 2013; 85
Myzak (ref_265) 2006; 27
Wang (ref_222) 2021; 78
Grothey (ref_330) 2014; 19
Chwatko (ref_386) 2013; 51
Rimola (ref_338) 2018; 67
Malumbres (ref_147) 2009; 9
Tarte (ref_91) 2002; 21
Mukherjee (ref_230) 2010; 103
Cenac (ref_241) 2016; 20
Xie (ref_379) 2016; 2016
Cai (ref_25) 2007; 76
Tsai (ref_255) 2012; 41
Lee (ref_166) 2014; 171
Tsou (ref_290) 2009; 33
Nagy (ref_110) 2015; 172
Lai (ref_238) 2013; 28
Mitchell (ref_191) 2016; 8
Wu (ref_250) 2017; 7
Radon (ref_132) 2014; 289
ref_13
Baskar (ref_196) 2011; 656
Calabrese (ref_195) 2016; 94
Chen (ref_279) 2016; 3
Yin (ref_139) 2013; 1491
Wang (ref_192) 2019; 20
Kimura (ref_69) 2011; 41
ref_15
Kundu (ref_186) 2014; 1843
Abe (ref_284) 2014; 5
Predmore (ref_68) 2012; 17
Bria (ref_351) 2015; 16
Zhou (ref_288) 2013; 4
Nagy (ref_75) 2015; 554
Chai (ref_226) 2021; 12
Li (ref_281) 2000; 60
Zhang (ref_12) 2016; 35
Bohanon (ref_102) 2014; 219
Nagpure (ref_242) 2015; 230
Askari (ref_3) 2018; 17
Li (ref_235) 2009; 47
Dongsoo (ref_126) 2018; 11
Fan (ref_103) 2014; 26
Zhang (ref_390) 2019; 10
Pan (ref_105) 2014; 763
Kolluru (ref_66) 2013; 35
Gupta (ref_368) 2016; 81
Wallace (ref_56) 2015; 14
Sundar (ref_202) 2017; 41
Wang (ref_29) 2020; 172
Cai (ref_104) 2010; 34
Tang (ref_275) 2004; 134
Mustafa (ref_101) 2009; 2
Ou (ref_325) 2019; 20
Zhen (ref_6) 2018; 15
Li (ref_199) 2015; 7
Sapena (ref_328) 2019; 49
Calabrese (ref_194) 2015; 62
Zhao (ref_231) 2011; 133
Wolf (ref_253) 2013; 66
Donnarumma (ref_64) 2011; 7
Sen (ref_95) 2015; 86
Lechuga (ref_154) 2019; 100
Tahara (ref_373) 2019; 106
Zhao (ref_311) 2015; 396
Bartkova (ref_148) 2005; 434
Chen (ref_197) 2019; 73
Wang (ref_58) 2012; 92
Czubak (ref_128) 1993; 25
Ma (ref_293) 2018; 33
Augsburger (ref_74) 2020; 154
Zhang (ref_111) 2015; 2015
Bertoli (ref_172) 2013; 14
Calvert (ref_42) 2010; 12
Zhang (ref_307) 2017; 38
Zhao (ref_109) 2014; 15
ref_161
Ma (ref_262) 2006; 28
Lee (ref_299) 2015; 230
Li (ref_211) 2020; 11
Ercolano (ref_150) 2020; 177
Ye (ref_83) 2020; 261
Libiad (ref_79) 2019; 294
Li (ref_236) 2008; 117
Teng (ref_87) 2013; 110
ref_170
ref_291
Lei (ref_318) 2018; 11
Wu (ref_309) 2019; 2019
Zheng (ref_187) 2016; 36
Hellmich (ref_100) 2015; 230
Howard (ref_176) 2007; 13
Ward (ref_358) 2012; 15
Rose (ref_73) 2017; 74
Yamagishi (ref_385) 2012; 61
Liu (ref_136) 2012; 17
Kabil (ref_45) 2010; 285
John (ref_4) 2017; 7
Levinn (ref_243) 2020; 32
Zhen (ref_312) 2015; 34
Lu (ref_168) 2010; 66
Yang (ref_48) 2004; 279
Yin (ref_112) 2012; 24
Sakuma (ref_9) 2019; 5
ref_40
Wu (ref_96) 2010; 285
ref_1
Shackelford (ref_31) 2021; 38
Tsai (ref_296) 2020; 35
Takano (ref_99) 2014; 12
Arai (ref_375) 2017; 107
Parikh (ref_198) 2014; 53
Fernandes (ref_315) 2015; 309
ref_8
Szczesny (ref_125) 2016; 6
Boyd (ref_319) 1995; 34
Yang (ref_108) 2008; 322
Bai (ref_121) 2019; 39
ref_98
Kumar (ref_383) 2012; 84
Kashfi (ref_181) 2014; 20
Wu (ref_256) 2011; 29
Li (ref_332) 2015; 16
Huang (ref_308) 2018; 38
Kimura (ref_219) 2010; 12
Ikuta (ref_365) 2009; 15
Schulze (ref_164) 2012; 491
Wu (ref_11) 2022; 2022
Wu (ref_248) 2015; 50
Kimura (ref_63) 2014; 20
Zhang (ref_93) 2005; 65
Yang (ref_247) 2020; 39
Lai (ref_283) 2017; 51
Goubern (ref_133) 2007; 21
Ostrakhovitch (ref_117) 2015; 330
Yao (ref_213) 2021; 22
Tripathi (ref_259) 2015; 6
Faro (ref_43) 2014; 41
Papapetropoulos (ref_134) 2009; 106
Yamaguchi (ref_336) 2019; 24
ref_71
Jin (ref_221) 2022; 10
PPowell (ref_2) 2018; 149
Wallace (ref_39) 2009; 137
Wallace (ref_38) 2007; 28
ref_78
Koniukh (ref_19) 2020; 14
Gai (ref_113) 2016; 34
Schmidinger (ref_341) 2013; 11
Wallace (ref_240) 2010; 159
Shackelford (ref_27) 2021; 28
Matsui (ref_364) 2008; 14
Crawford (ref_344) 2017; 35
Fernandes (ref_77) 2020; Volume 1219
Liu (ref_227) 2021; 277
Meng (ref_378) 2015; 2015
ref_81
Reig (ref_337) 2014; 61
Benavides (ref_67) 2007; 104
Ma (ref_94) 2014; 21
ref_88
Wang (ref_185) 2017; 8
Yao (ref_158) 2022; 9
Wang (ref_232) 2010; 12
Szabo (ref_34) 2013; 110
(ref_49) 2015; 67
Katsouda (ref_26) 2016; 113
Xie (ref_294) 2017; 7
Kaltschmidt (ref_193) 1997; 20
Dickler (ref_347) 2008; 14
Dixon (ref_208) 2012; 149
Meram (ref_124) 2018; 38
Bouillaud (ref_46) 2011; 15
Rees (ref_348) 2011; 7
Maclean (ref_70) 2004; 279
Gong (ref_180) 2011; 25
Ghatalia (ref_350) 2015; 112
Boss (ref_370) 2012; 106
Matsui (ref_363) 2008; 122
Ariyaratnam (ref_37) 2013; 90
Nagahara (ref_131) 2018; 175
Li (ref_206) 2021; 24
Tang (ref_286) 2016; 35
Li (ref_234) 2013; 6
Grothey (ref_322) 2013; 381
Hanahan (ref_163) 2011; 144
Yamazaki (ref_374) 2019; 98
Liu (ref_162) 2021; 11
Zhou (ref_138) 2017; 104
Murata (ref_182) 2014; 320
Vandiver (ref_175) 2013; 4
Hong (ref_174) 2014; 34
Li (ref_327) 2017; 119
Wu (ref_33) 2018; 131
Kasiappan (ref_285) 2016; 291
Lee (ref_300) 2017; 8
Citi (ref_251) 2019; 33
Molina (ref_371) 2014; 73
Lee (ref_244) 2010; 285
Bachelot (ref_361) 2016; 4
Ngowi (ref_18) 2020; 11
Ngowi (ref_7) 2021; 17
Chiku (ref_44) 2009; 284
Zhu (ref_295) 2013; 14
Whiteman (ref_179) 2010; 12
Ma (ref_317) 2019; 52
Patel (ref_345) 2011; 6
Osaki (ref_149) 2004; 9
Bhatt (ref_384) 2015; 84
Searcy (ref_65) 1998; 282
Szabo (ref_22) 2015; 15
Guo (ref_246) 2013; 34
Lv (ref_302) 2014; 10
Meng (ref_377) 2015; 29
Zuhra (ref_80) 2019; 2019
Dilek (ref_204) 2020; 161
Dilek (ref_85) 2021; 165
Stephan (ref_388) 2015; 46
Jasim (ref_372) 2017; 23
Reis (ref_249) 2019; 27
Akbari (ref_76) 2019; 2019
Chen (ref_216) 2021; 23
Evan (ref_169) 2001; 411
Pei (ref_107) 2011; 257
Tiong (ref_142) 2010; 161
Murphy (ref_189) 2018; 32
Bankhele (ref_50) 2018; 43
Ye (ref_306) 2020; 195
McLellan (ref_329) 2015; 26
Hartle (ref_23) 2016; 45
Cao (ref_32) 2019; 31
Panagaki (ref_155) 2022; 51
Xu (ref_267) 2005; 24
ref_316
Paul (ref_28) 2021; 38
Li (ref_314) 2017; 13
Cao (ref_381) 2016; 7
Shumaker (ref_367) 2014; 52
Schutz (ref_343) 2012; 30
Panza (ref_89) 2015; 28
Kim (ref_287) 2010; 3
Vogelzang (ref_357) 2015; 13
Shen (ref_59) 2013; 60
Vrdoljak (ref_342) 2012; 13
Hellmich (ref_10) 2018; 149
Wang (ref_376) 2019; 18
Salvi (ref_53) 2016; 41
Xu (ref_353) 2012; 23
Zhang (ref_21) 2018; 9
Wu (ref_35) 2015; 2015
Coletta (ref_116) 2013; 27
Dubrovska (ref_36) 2012; 8
Lu (ref_171) 2014; 44
Hamberg (ref_362) 2015; 75
Baskar (ref_17) 2008; 594
(ref_57) 2007; 6
Lawson (ref_269) 2015; 75
Hasegawa (ref_239) 2014; 25
Kalkunte (ref_301) 2006; 5
Greiner (ref_190) 2013; 19
Aguirre (ref_207) 2021; 153
Zhang (ref_97) 2011; 52
Kun (ref_127) 1960; 16
Tsubura (ref_228) 2011; 11
Kim (ref_323) 2019; 18
Honda (ref_188) 2021; 41
Nakamichi (ref_369) 2015; 76
Szabo (ref_86) 2014; 171
Arif (ref_157) 2022; 36
Lu (ref_278) 2008; 1
Santoni (ref_360) 2015; 136
Sobolewski (ref_276) 2007; 6
Galmarini (ref_382) 2007; 99
Li (ref_153) 2021; 45
Escudier (ref_356) 2012; 9
Tabassum (ref_215) 2019; 16
Pappa (ref_261) 2006; 599
Sehrawat (ref_292) 2016; 30
Czubak (ref_122) 2014; 19
Salvi (ref_54) 2016; 32
Yeh (ref_298) 2016; 97
Lam (ref_252) 2009; 18
Aghagolzadeh (ref_16) 2017; 265
Qian (ref_20) 2016; 473
Nian (ref_177) 2009; 50
Mustafa (ref_135) 2011; 109
Middleton (ref_200) 2015; 9
Teo (ref_352) 2013; 39
Shiota (ref_123) 2018; 9
Govar (ref_130) 2020; 177
Levitt (ref_47) 2011; 15
Yue (ref_82) 2020; 11
Bruheim (ref_366) 2011; 129
Calabrese (ref_229) 2010; 13
References_xml – ident: ref_15
  doi: 10.3390/ijms22042194
– volume: 74
  start-page: 1391
  year: 2017
  ident: ref_73
  article-title: H2S biosynthesis and catabolism: New insights from molecular studies
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-016-2406-8
– volume: 15
  start-page: 6562
  year: 2018
  ident: ref_6
  article-title: Exogenous hydrogen sulfide promotes hepatocellular carcinoma cell growth by activating the STAT3-COX-2 signaling pathway
  publication-title: Oncol. Lett.
– volume: 29
  start-page: 1199
  year: 2011
  ident: ref_256
  article-title: Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human osteogenic sarcoma U-2 OS cells
  publication-title: J. Orthop. Res.
  doi: 10.1002/jor.21350
– volume: 14
  start-page: 2607
  year: 2013
  ident: ref_295
  article-title: Inhibitory effect of benzyl isothiocyanate on proliferation in vitro of human glioma cells
  publication-title: Asian Pac. J. Cancer Prev.
  doi: 10.7314/APJCP.2013.14.4.2607
– volume: 163
  start-page: 217
  year: 2003
  ident: ref_92
  article-title: Identification of Novel Cellular Targets in Biliary Tract Cancers Using Global Gene Expression Technology
  publication-title: Am. J. Pathol.
  doi: 10.1016/S0002-9440(10)63645-0
– volume: 39
  start-page: 187
  year: 2020
  ident: ref_247
  article-title: Role of Hydrogen Sulfide in Chronic Diseases
  publication-title: DNA Cell Biol.
  doi: 10.1089/dna.2019.5067
– volume: 113
  start-page: 175
  year: 2016
  ident: ref_26
  article-title: Regulation and role of endogenously produced hydrogen sulfide in angiogenesis
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2016.08.026
– volume: 75
  start-page: 365
  year: 2015
  ident: ref_362
  article-title: Impact of pazopanib on docetaxel exposure: Results of a phase I combination study with two different docetaxel schedules
  publication-title: Cancer Chemother. Pharmacol.
  doi: 10.1007/s00280-014-2655-x
– volume: 656
  start-page: 5
  year: 2011
  ident: ref_196
  article-title: Hydrogen sulfide gas has cell growth regulatory role
  publication-title: Eur. J. Pharmacol.
  doi: 10.1016/j.ejphar.2011.01.052
– volume: 64
  start-page: 171
  year: 2017
  ident: ref_115
  article-title: Hydrogen sulfide generation from L-cysteine in the human glioblastoma-astrocytoma U-87 MG and neuroblastoma SHSY5Y cell lines
  publication-title: Acta Biochim. Pol.
– volume: 13
  start-page: 829
  year: 2017
  ident: ref_314
  article-title: Effects of exogenous hydrogen sulfide on the proliferation and invasion of human Bladder cancer cells
  publication-title: J. Cancer Res. Ther.
  doi: 10.4103/jcrt.JCRT_423_17
– volume: 11
  start-page: 1828
  year: 2020
  ident: ref_82
  article-title: Aminooxyacetic acid (AOAA) sensitizes colon cancer cells to oxaliplatin via exaggerating apoptosis induced by ROS
  publication-title: J. Cancer
  doi: 10.7150/jca.35375
– volume: 9
  start-page: 153
  year: 2009
  ident: ref_147
  article-title: Cell cycle, CDKs and cancer: A changing paradigm
  publication-title: Nat. Cancer
  doi: 10.1038/nrc2602
– volume: 49
  start-page: 482
  year: 2019
  ident: ref_328
  article-title: Systematic review with meta-analysis: The critical role of dermatological events in patients with hepatocellular carcinoma treated with sorafenib
  publication-title: Aliment. Pharmacol. Ther.
  doi: 10.1111/apt.15088
– volume: 1843
  start-page: 2816
  year: 2014
  ident: ref_186
  article-title: Hydrogen sulfide mitigates hyperglycemic remodeling via liver kinase B1-adenosine monophosphate-activated protein kinase signaling
  publication-title: Biochim. Biophys. Acta (BBA)-Mol. Cell Res.
  doi: 10.1016/j.bbamcr.2014.08.005
– volume: 30
  start-page: 67
  year: 2016
  ident: ref_292
  article-title: Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanate
  publication-title: Mitochondrion
  doi: 10.1016/j.mito.2016.06.006
– volume: 6
  start-page: 181
  year: 2011
  ident: ref_345
  article-title: Toxicities of targeted agents in advanced renal cell carcinoma
  publication-title: Curr. Clin. Pharmacol.
  doi: 10.2174/157488411797189442
– volume: 23
  start-page: 2470
  year: 2012
  ident: ref_353
  article-title: Concomitant use of pazopanib and simvastatin increases the risk of transaminase elevations in patients with cancer
  publication-title: Ann. Oncol.
  doi: 10.1093/annonc/mds249
– volume: 103
  start-page: 815
  year: 2010
  ident: ref_230
  article-title: Comparison of the protective effects of steamed and cooked broccolis on ischaemia–reperfusion-induced cardiac injury
  publication-title: Br. J. Nutr.
  doi: 10.1017/S0007114509992492
– volume: 136
  start-page: 1
  year: 2015
  ident: ref_360
  article-title: Treatment-related fatigue with sorafenib, sunitinib and pazopanib in patients with advanced solid tumors: An up-to-date review and meta-analysis of clinical trials
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.28715
– volume: 79
  start-page: 483.e1
  year: 2012
  ident: ref_90
  article-title: Characterization of Hydrogen Sulfide and Its Synthases, Cystathionine β-Synthase and Cystathionine γ-Lyase, in Human Prostatic Tissue and Cells
  publication-title: Urology
  doi: 10.1016/j.urology.2011.10.013
– volume: 10
  start-page: 68
  year: 2011
  ident: ref_263
  article-title: Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: Competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly
  publication-title: Mol. Cancer
  doi: 10.1186/1476-4598-10-68
– ident: ref_291
  doi: 10.3390/biom9120839
– volume: 27
  start-page: 101190
  year: 2019
  ident: ref_249
  article-title: S-nitrosothiols and H2 donors: Potential chemo-therapeutic agents in cancer
  publication-title: Redox Biol.
  doi: 10.1016/j.redox.2019.101190
– volume: 75
  start-page: 5130
  year: 2015
  ident: ref_269
  article-title: Naturally Occurring Isothiocyanates Exert Anticancer Effects by Inhibiting Deubiquitinating Enzymes
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-15-1544
– volume: 2019
  start-page: 2360945
  year: 2019
  ident: ref_76
  article-title: Hydrogen Sulfide: Emerging Role in Bladder, Kidney, and Prostate Malignancies
  publication-title: Oxidative Med. Cell. Longev.
  doi: 10.1155/2019/2360945
– volume: 153
  start-page: 116168
  year: 2021
  ident: ref_207
  article-title: Biologic and pathologic aspects of osteocytes in the setting of medication-related osteonecrosis of the jaw (MRONJ)
  publication-title: Bone
  doi: 10.1016/j.bone.2021.116168
– ident: ref_88
  doi: 10.1371/journal.pone.0079167
– volume: 97
  start-page: 336
  year: 2016
  ident: ref_298
  article-title: Benzyl isothiocyanate promotes apoptosis of oral cancer cells via an acute redox stress-mediated DNA damage response
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2016.09.028
– volume: 7
  start-page: 149
  year: 2021
  ident: ref_210
  article-title: Implication of ferroptosis in aging
  publication-title: Cell Death Discov.
  doi: 10.1038/s41420-021-00553-6
– volume: 2016
  start-page: 6043038
  year: 2016
  ident: ref_379
  article-title: Hydrogen Sulfide and Cellular Redox Homeostasis
  publication-title: Oxidative Med. Cell. Longev.
  doi: 10.1155/2016/6043038
– volume: 9
  start-page: 1561
  year: 2018
  ident: ref_123
  article-title: Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-03899-1
– volume: 10
  start-page: e0122062
  year: 2015
  ident: ref_14
  article-title: Investigation of Hydrogen Sulfide Exposure and Lung Function, Asthma and Chronic Obstructive Pulmonary Disease in a Geothermal Area of New Zealand
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0122062
– volume: 154
  start-page: 104083
  year: 2020
  ident: ref_74
  article-title: Potential role of the 3-mercaptopyruvate sulfurtransferase (3-MST)—Hydrogen sulfide (H2S) pathway in cancer cells
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2018.11.034
– volume: 72
  start-page: 2394
  year: 2012
  ident: ref_233
  article-title: Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor–negative breast cancer
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-11-3115
– volume: 104
  start-page: 17977
  year: 2007
  ident: ref_67
  article-title: Hydrogen sulfide mediates the vasoactivity of garlic
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0705710104
– volume: 46
  start-page: 2194
  year: 2015
  ident: ref_141
  article-title: Exogenous hydrogen sulfide exerts proliferation/anti-apoptosis/angiogenesis/migration effects via amplifying the activation of NF-κB pathway in PLC/PRF/5 hepatoma cells
  publication-title: Int. J. Oncol.
  doi: 10.3892/ijo.2015.2914
– ident: ref_254
  doi: 10.1016/bs.enz.2015.05.003
– volume: 52
  start-page: 288
  year: 2018
  ident: ref_220
  article-title: Hydrogen sulfide increases glutathione biosynthesis, and glucose uptake and utilisation in C2C12 mouse myotubes
  publication-title: Free. Radic. Res.
  doi: 10.1080/10715762.2018.1431626
– volume: 14
  start-page: 289
  year: 2020
  ident: ref_19
  article-title: Hydrogen Sulfide Metabolism and Its Role in Kidney Function in a Rat Model of Chronic Kidney Disease
  publication-title: Health Probl. Civiliz.
  doi: 10.5114/hpc.2020.96571
– volume: 2015
  start-page: 186908
  year: 2015
  ident: ref_35
  article-title: Role of Hydrogen Sulfide in Ischemia-Reperfusion Injury
  publication-title: Oxidative Med. Cell. Longev.
  doi: 10.1155/2015/186908
– volume: 12
  start-page: 706814
  year: 2021
  ident: ref_226
  article-title: A Nomogram Integrating Ferroptosis- and Immune-Related Biomarkers for Prediction of Overall Survival in Lung Adenocarcinoma
  publication-title: Front. Genet.
  doi: 10.3389/fgene.2021.706814
– volume: 34
  start-page: 699
  year: 2014
  ident: ref_174
  article-title: Effect of hydrogen sulfide on human colon cancer SW480 cell proliferation and migration in vitro
  publication-title: Nan Fang Yi Ke Da Xue Xue Bao = J. South. Med. Univ.
– volume: 52
  start-page: 2276
  year: 2012
  ident: ref_60
  article-title: Analytical measurement of discrete hydrogen sulfide pools in biological specimens
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2012.04.007
– volume: 161
  start-page: 105119
  year: 2020
  ident: ref_204
  article-title: Hydrogen sulfide: An endogenous regulator of the immune system
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2020.105119
– volume: 11
  start-page: 249
  year: 2011
  ident: ref_228
  article-title: Anticancer effects of garlic and garlic-derived compounds for breast cancer control
  publication-title: Anti-Cancer Agents Med. Chem. (Former. Curr. Med. Chem. Anti-Cancer Agents)
– volume: 94
  start-page: 1588
  year: 2016
  ident: ref_195
  article-title: Major pathogenic mechanisms in vascular dementia: Roles of cellular stress response and hormesis in neuroprotection
  publication-title: J. Neurosci. Res.
  doi: 10.1002/jnr.23925
– volume: 84
  start-page: 597
  year: 2015
  ident: ref_384
  article-title: Volatile organic compounds in plasma for the diagnosis of esophageal adenocarcinoma: A pilot study
  publication-title: Gastrointest. Endosc.
  doi: 10.1016/j.gie.2015.11.031
– volume: 330
  start-page: 135
  year: 2015
  ident: ref_117
  article-title: Dedifferentiation of cancer cells following recovery from a potentially lethal damage is mediated by H2–Nampt
  publication-title: Exp. Cell Res.
  doi: 10.1016/j.yexcr.2014.09.027
– volume: 20
  start-page: 831
  year: 2014
  ident: ref_181
  article-title: Anti-Cancer Activity of New Designer Hydrogen Sulfide-Donating Hybrids
  publication-title: Antioxi. Redox Signal.
  doi: 10.1089/ars.2013.5308
– volume: 36
  start-page: 275
  year: 2022
  ident: ref_157
  article-title: Signaling Integration of Hydrogen Sulfide and Iron on Cellular Functions
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2021.0203
– ident: ref_156
  doi: 10.1159/000521671
– volume: 434
  start-page: 864
  year: 2005
  ident: ref_148
  article-title: DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
  publication-title: Nature
  doi: 10.1038/nature03482
– volume: 18
  start-page: 184
  year: 2009
  ident: ref_252
  article-title: Cruciferous Vegetable Consumption and Lung Cancer Risk: A Systematic Review
  publication-title: Cancer Epidemiol. Biomark. Prev.
  doi: 10.1158/1055-9965.EPI-08-0710
– volume: 58
  start-page: 7501
  year: 2015
  ident: ref_41
  article-title: Design, synthesis, and cardioprotective effects of N-mercapto-based hydrogen sulfide donors
  publication-title: J. Med. Chem.
  doi: 10.1021/acs.jmedchem.5b01033
– volume: 159
  start-page: 1236
  year: 2010
  ident: ref_240
  article-title: Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346)
  publication-title: J. Cereb. Blood Flow Metab.
– volume: 34
  start-page: 1154
  year: 2020
  ident: ref_310
  article-title: Diallyl trisulfide, a H2 donor, inhibits cell growth of human papillary thyroid carcinoma KTC-1 cells through a positive feedback loop between H2 and cystathionine-gamma-lyase
  publication-title: Phytother. Res.
  doi: 10.1002/ptr.6586
– volume: 56
  start-page: 611
  year: 2010
  ident: ref_106
  article-title: Glutathione depletion causes a JNK and p38MAPK-mediated increase in expression of cystathionine-γ-lyase and upregulation of the transsulfuration pathway in C6 glioma cells
  publication-title: Neurochem. Int.
  doi: 10.1016/j.neuint.2010.01.004
– volume: 2015
  start-page: 1
  year: 2015
  ident: ref_111
  article-title: An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells
  publication-title: Oxidative Med. Cell. Longev.
– volume: 13
  start-page: 1847
  year: 2007
  ident: ref_176
  article-title: Garlic-Derived S-allylmercaptocysteine Is a Novel In vivo Antimetastatic Agent for Androgen-Independent Prostate Cancer
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-06-2074
– volume: 24
  start-page: 183
  year: 2010
  ident: ref_340
  article-title: Current status of vascular endothelial growth factor inhibition in age-related macular degeneration
  publication-title: BioDrugs
  doi: 10.2165/11318550-000000000-00000
– volume: 99
  start-page: 1441
  year: 2007
  ident: ref_382
  article-title: Drug Resistance and the Solid Tumor Microenvironment
  publication-title: J. Natl. Cancer Inst.
  doi: 10.1093/jnci/djm135
– volume: 66
  start-page: 285
  year: 2013
  ident: ref_253
  article-title: Benzyl Isothiocyanate Inhibits HNSCC Cell Migration and Invasion, and Sensitizes HNSCC Cells to Cisplatin
  publication-title: Nutr. Cancer
  doi: 10.1080/01635581.2014.868912
– volume: 20
  start-page: e45986
  year: 2019
  ident: ref_192
  article-title: Dysregulation of cystathionine γ-lyase promotes prostate cancer progression and metastasis
  publication-title: EMBO Rep.
  doi: 10.15252/embr.201845986
– volume: 16
  start-page: 1386
  year: 2019
  ident: ref_215
  article-title: Potential for therapeutic use of hydrogen sulfide in oxidative stress-induced neurodegenerative diseases
  publication-title: Int. J. Med. Sci.
  doi: 10.7150/ijms.36516
– volume: 13
  start-page: 210
  year: 2015
  ident: ref_357
  article-title: First-Line and Sequential Use of Pazopanib Followed by Mammalian Target of Rapamycin Inhibitor Therapy Among Patients with Advanced Renal Cell Carcinoma in a US Community Oncology Setting
  publication-title: Clin. Genitourin. Cancer
  doi: 10.1016/j.clgc.2014.11.001
– volume: 411
  start-page: 342
  year: 2001
  ident: ref_169
  article-title: Proliferation, cell cycle and apoptosis in cancer
  publication-title: Nature
  doi: 10.1038/35077213
– volume: 16
  start-page: 1792
  year: 2002
  ident: ref_24
  article-title: Two’s company, three’s a crowd: Can H2S be the third endogenous gaseous transmitter?
  publication-title: FASEB J.
  doi: 10.1096/fj.02-0211hyp
– volume: 2019
  start-page: 6927298
  year: 2019
  ident: ref_309
  article-title: Exogenous Hydrogen Sulfide Regulates the Growth of Human Thyroid Carcinoma Cells
  publication-title: Oxidative Med. Cell. Longev.
  doi: 10.1155/2019/6927298
– volume: 9
  start-page: 47
  year: 2010
  ident: ref_273
  article-title: Sulforaphane induces cell cycle arrest by protecting RB-E2F-1 complex in epithelial ovarian cancer cells
  publication-title: Mol. Cancer
  doi: 10.1186/1476-4598-9-47
– volume: 35
  start-page: 2825
  year: 2016
  ident: ref_12
  article-title: Hydrogen sulfide promotes cell proliferation of oral cancer through activation of the COX2/AKT/ERK1/2 axis
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2016.4691
– volume: 6
  start-page: 36125
  year: 2016
  ident: ref_125
  article-title: Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics
  publication-title: Sci. Rep.
  doi: 10.1038/srep36125
– volume: 4
  start-page: 1626
  year: 2013
  ident: ref_175
  article-title: Sulfhydration mediates neuroprotective actions of parkin
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms2623
– volume: 594
  start-page: 1
  year: 2008
  ident: ref_17
  article-title: Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative inhibit rat vascular smooth muscle cell proliferation
  publication-title: Eur. J. Pharmacol.
  doi: 10.1016/j.ejphar.2008.07.029
– volume: 15
  start-page: 792
  year: 2014
  ident: ref_109
  article-title: S-sulfhydration of MEK 1 leads to PARP-1 activation and DNA damage repair
  publication-title: EMBO Rep.
  doi: 10.1002/embr.201338213
– volume: 14
  start-page: 518
  year: 2013
  ident: ref_172
  article-title: Control of cell cycle transcription during G1 and S phases
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3629
– ident: ref_13
  doi: 10.3390/biom11050682
– volume: 5
  start-page: e1534
  year: 2014
  ident: ref_284
  article-title: Nuclear factor-kappaB sensitizes to benzyl isothiocyanate-induced antiproliferation in p53-deficient colorectal cancer cells
  publication-title: Cell Death Dis.
  doi: 10.1038/cddis.2014.495
– ident: ref_159
  doi: 10.3390/nano12020258
– ident: ref_8
  doi: 10.1371/journal.pone.0021077
– volume: 41
  start-page: 101926
  year: 2021
  ident: ref_188
  article-title: On-tissue polysulfide visualization by surface-enhanced Raman spectroscopy benefits patients with ovarian cancer to predict post-operative chemosensitivity
  publication-title: Redox Biol.
  doi: 10.1016/j.redox.2021.101926
– volume: 52
  start-page: 284
  year: 2014
  ident: ref_367
  article-title: Evaluation of the effects of formulation and food on the pharmacokinetics of lenvatinib (E7080) in healthy volunteers
  publication-title: Int. J. Clin. Pharmacol. Ther.
  doi: 10.5414/CP201937
– volume: 122
  start-page: 664
  year: 2008
  ident: ref_363
  article-title: E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.23131
– volume: 291
  start-page: 27122
  year: 2016
  ident: ref_285
  article-title: Benzyl Isothiocyanate (BITC) Induces Reactive Oxygen Species-dependent Repression of STAT3 Protein by Down-regulation of Specificity Proteins in Pancreatic Cancer
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M116.746339
– volume: 127
  start-page: 1116
  year: 2013
  ident: ref_51
  article-title: H2S Protects Against Pressure Overload–Induced Heart Failure via Upregulation of Endothelial Nitric Oxide Synthase
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.112.000855
– volume: 24
  start-page: 1229
  year: 2012
  ident: ref_112
  article-title: Sp1 is involved in regulation of cystathionine γ-lyase gene expression and biological function by PI3K/Akt pathway in human hepatocellular carcinoma cell lines
  publication-title: Cell. Signal.
  doi: 10.1016/j.cellsig.2012.02.003
– volume: 81
  start-page: 1124
  year: 2016
  ident: ref_368
  article-title: Population pharmacokinetic analysis of lenvatinib in healthy subjects and patients with cancer
  publication-title: Br. J. Clin. Pharmacol.
  doi: 10.1111/bcp.12907
– volume: 76
  start-page: 29
  year: 2007
  ident: ref_25
  article-title: The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation
  publication-title: Cardiovasc. Res.
  doi: 10.1016/j.cardiores.2007.05.026
– volume: 285
  start-page: 21903
  year: 2010
  ident: ref_45
  article-title: Redox Biochemistry of Hydrogen Sulfide
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.R110.128363
– volume: 13
  start-page: 159
  year: 2012
  ident: ref_342
  article-title: Optimizing treatment for patients with metastatic renal cell carcinoma in the central and Eastern European region
  publication-title: Expert Opin. Pharmacother.
  doi: 10.1517/14656566.2012.647406
– volume: 149
  start-page: 186
  year: 2018
  ident: ref_10
  article-title: Role of endogenous and exogenous nitric oxide, carbon monoxide and hydrogen sulfide in HCT116 colon cancer cell proliferation
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2017.10.011
– volume: 6
  start-page: 917
  year: 2007
  ident: ref_57
  article-title: Hydrogen sulphide and its therapeutic potential
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd2425
– volume: 279
  start-page: 8558
  year: 2004
  ident: ref_70
  article-title: The Dominant Role of Sp1 in Regulating the Cystathionine β-Synthase –1a and –1b Promoters Facilitates Potential Tissue-specific Regulation by Kruppel-like Factors
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M310211200
– volume: 6
  start-page: 5237
  year: 2015
  ident: ref_259
  article-title: Allyl isothiocyanate induces replication-associated DNA damage response in NSCLC cells and sensitizes to ionizing radiation
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.3026
– volume: 112
  start-page: 296
  year: 2015
  ident: ref_350
  article-title: QTc interval prolongation with vascular endothelial growth factor receptor tyrosine kinase inhibitors
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.2014.564
– volume: 131
  start-page: 120
  year: 2018
  ident: ref_33
  article-title: Hydrogen sulfide and autophagy: A double edged sword
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2018.03.002
– volume: 20
  start-page: 723
  year: 2016
  ident: ref_241
  article-title: A novel orally administered trimebutine compound (GIC-1001) is anti-nociceptive and features peripheral opioid agonistic activity and Hydrogen Sulphide-releasing capacity in mice
  publication-title: Eur. J. Pain
  doi: 10.1002/ejp.798
– ident: ref_209
  doi: 10.3390/ijms22179271
– volume: 28
  start-page: 479
  year: 2013
  ident: ref_238
  article-title: Diallyl sulfide, diallyl disulfide, and diallyl trisulfide inhibit migration and invasion in human colon cancer colo 205 cells through the inhibition of matrix metalloproteinase-2, -7, and -9 expressions
  publication-title: Environ. Toxicol.
  doi: 10.1002/tox.20737
– volume: 283
  start-page: 30151
  year: 2008
  ident: ref_277
  article-title: Benzyl Isothiocyanate Targets Mitochondrial Respiratory Chain to Trigger Reactive Oxygen Species-dependent Apoptosis in Human Breast Cancer Cells
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M802529200
– volume: 32
  start-page: 2226
  year: 2018
  ident: ref_173
  article-title: Effect of glucoraphanin and sulforaphane against chemotherapy-induced neuropathic pain: Kv7 potassium channels modulation by H2 S release in vivo
  publication-title: Phytother. Res.
  doi: 10.1002/ptr.6159
– volume: 26
  start-page: 2017
  year: 2015
  ident: ref_329
  article-title: Regorafenib-associated hand–foot skin reaction: Practical advice on diagnosis, prevention, and management
  publication-title: Ann. Oncol.
  doi: 10.1093/annonc/mdv244
– volume: 25
  start-page: 1409
  year: 2004
  ident: ref_271
  article-title: Allyl-isothiocyanate causes mitotic block, loss of cell adhesion and disrupted cytoskeletal structure in HT29 cells
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgh149
– volume: 14
  start-page: 7878
  year: 2008
  ident: ref_347
  article-title: A Phase II Trial of Erlotinib in Combination with Bevacizumab in Patients with Metastatic Breast Cancer
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-08-0141
– volume: 15
  start-page: 87
  year: 2012
  ident: ref_358
  article-title: A randomized, phase II study of pazopanib in castrate-sensitive prostate cancer: A University of Chicago Phase II Consortium/Department of Defense Prostate Cancer Clinical Trials Consortium study
  publication-title: Prostate Cancer Prostatic Dis.
  doi: 10.1038/pcan.2011.49
– volume: 27
  start-page: 475
  year: 2006
  ident: ref_280
  article-title: Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with β-phenylethyl isothiocyanate and curcumin
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgi272
– volume: 17
  start-page: 119
  year: 2012
  ident: ref_68
  article-title: Hydrogen Sulfide in Biochemistry and Medicine
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2012.4612
– volume: 110
  start-page: 12679
  year: 2013
  ident: ref_87
  article-title: Oxygen-sensitive mitochondrial accumulation of cystathionine β-synthase mediated by Lon protease
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1308487110
– volume: 33
  start-page: 1505
  year: 2009
  ident: ref_290
  article-title: Benzyl isothiocyanate inhibits murine WEHI-3 leukemia cells in vitro and promotes phagocytosis in BALB/c mice in vivo
  publication-title: Leuk. Res.
  doi: 10.1016/j.leukres.2009.01.030
– volume: 29
  start-page: 203
  year: 2015
  ident: ref_377
  article-title: GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats
  publication-title: J. Biomed. Res.
  doi: 10.7555/JBR.28.20140037
– volume: 17
  start-page: 14
  year: 2018
  ident: ref_3
  article-title: Protective effects of hydrogen sulfide on chronic kidney disease by reducing oxidative stress, inflammation and apoptosis
  publication-title: EXCLI J.
– volume: 2022
  start-page: 1886277
  year: 2022
  ident: ref_11
  article-title: Role of Hydrogen Sulfide in Oral Disease
  publication-title: Oxidative Med. Cell. Longev.
– volume: 161
  start-page: 467
  year: 2010
  ident: ref_142
  article-title: Protective effect of hydrogen sulphide against 6-OHDA-induced cell injury in SH-SY5Y cells involves PKC/PI3K/Akt pathway
  publication-title: J. Cereb. Blood Flow Metab.
– volume: 11
  start-page: 671
  year: 2011
  ident: ref_165
  article-title: Dysregulated pH: A perfect storm for cancer progression
  publication-title: Nat. Cancer
  doi: 10.1038/nrc3110
– volume: 61
  start-page: 554
  year: 2012
  ident: ref_385
  article-title: Generation of gaseous sulfur-containing compounds in tumour tissue and suppression of gas diffusion as an antitumour treatment
  publication-title: Gut
  doi: 10.1136/gutjnl-2011-300721
– volume: 38
  start-page: 101772
  year: 2021
  ident: ref_28
  article-title: Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics
  publication-title: Redox Biol.
  doi: 10.1016/j.redox.2020.101772
– volume: 2012
  start-page: 718320
  year: 2012
  ident: ref_258
  article-title: Phenethyl Isothiocyanate (PEITC) inhibits the growth of human oral squamous carcinoma HSC-3 cells through G0/G1 phase arrest and mitochondria-mediated apoptotic cell death
  publication-title: Evid. Based Complement. Altern. Med.
  doi: 10.1155/2012/718320
– volume: 289
  start-page: 34543
  year: 2014
  ident: ref_132
  article-title: Characterization and Interaction Studies of Two Isoforms of the Dual Localized 3-Mercaptopyruvate Sulfurtransferase TUM1 from Humans
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M114.605733
– volume: 73
  start-page: 55
  year: 2019
  ident: ref_197
  article-title: The Ataxia telangiectasia-mutated and Rad3-related protein kinase regulates cellular hydrogen sulfide concentrations
  publication-title: DNA Repair
  doi: 10.1016/j.dnarep.2018.11.002
– volume: 8
  start-page: 2776
  year: 2017
  ident: ref_203
  article-title: A new H2S-specific near-infrared fluorescence-enhanced probe that can visualize the H2S level in colorectal cancer cells in mice
  publication-title: Chem. Sci.
  doi: 10.1039/C6SC05646F
– volume: 60
  start-page: 1426
  year: 2000
  ident: ref_281
  article-title: Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells
  publication-title: Cancer Res.
– volume: 62
  start-page: 530
  year: 2015
  ident: ref_194
  article-title: HORMESIS: A Fundamental Concept with Widespread Biological and Biomedical Applications
  publication-title: Gerontology
  doi: 10.1159/000441520
– volume: 137
  start-page: 569
  year: 2009
  ident: ref_39
  article-title: Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2009.04.012
– volume: 15
  start-page: 379
  year: 2011
  ident: ref_46
  article-title: Mitochondria and Sulfide: A Very Old Story of Poisoning, Feeding, and Signaling?
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2010.3678
– volume: 284
  start-page: 11601
  year: 2009
  ident: ref_44
  article-title: H2S Biogenesis by Human Cystathionine γ-Lyase Leads to the Novel Sulfur Metabolites Lanthionine and Homolanthionine and Is Responsive to the Grade of Hyperhomocysteinemia
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M808026200
– volume: 9
  start-page: 168
  year: 2022
  ident: ref_158
  article-title: A ROS-responsive, self-immolative and self-reporting hydrogen sulfide donor with multiple biological activities for the treatment of myocardial infarction
  publication-title: Bioact. Mater.
– volume: 119
  start-page: 50
  year: 2017
  ident: ref_327
  article-title: Hand-foot skin reaction with vascular endothelial growth factor receptor tyrosine kinase inhibitors in cancer patients: A systematic review and meta-analysis
  publication-title: Crit. Rev. Oncol.
  doi: 10.1016/j.critrevonc.2017.09.016
– volume: 5
  start-page: e02244
  year: 2019
  ident: ref_9
  article-title: Hydrogen sulfide donor GYY4137 suppresses proliferation of human colorectal cancer Caco-2 cells by inducing both cell cycle arrest and cell death
  publication-title: Heliyon
  doi: 10.1016/j.heliyon.2019.e02244
– volume: 2019
  start-page: 8102936
  year: 2019
  ident: ref_80
  article-title: Hydrogen Sulfide Oxidation: Adaptive Changes in Mitochondria of SW480 Colorectal Cancer Cells upon Exposure to Hypoxia
  publication-title: Oxidative Med. Cell. Longev.
– volume: 282
  start-page: 310
  year: 1998
  ident: ref_65
  article-title: Sulfur reduction by human erythrocytes
  publication-title: J. Exp. Zool.
  doi: 10.1002/(SICI)1097-010X(19981015)282:3<310::AID-JEZ4>3.0.CO;2-P
– volume: 19
  start-page: 1749
  year: 2013
  ident: ref_190
  article-title: Polysulfides link H2 to protein thiol oxidation
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2012.5041
– ident: ref_170
  doi: 10.1371/journal.pone.0037572
– volume: 44
  start-page: 1259
  year: 2014
  ident: ref_171
  article-title: GYY4137, a hydrogen sulfide (H2) donor, shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway
  publication-title: Int. J. Oncol.
  doi: 10.3892/ijo.2014.2305
– volume: 7
  start-page: 583
  year: 2011
  ident: ref_64
  article-title: Protective Actions of H2S in Acute Myocardial Infarction and Heart Failure
  publication-title: Compr. Physiol.
– volume: 28
  start-page: 1287
  year: 2006
  ident: ref_262
  article-title: Phenylhexyl isothiocyanate inhibits histone deacetylases and remodels chromatins to induce growth arrest in human leukemia cells
  publication-title: Int. J. Oncol.
– volume: 86
  start-page: 228
  year: 2015
  ident: ref_95
  article-title: Role of cystathionine β-synthase in human breast Cancer
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2015.05.024
– volume: 16
  start-page: 399
  year: 2015
  ident: ref_351
  article-title: Treatment of Unfit Patients with Advanced Non–Small-Cell Lung Cancer: Definition Criteria According an Expert Panel
  publication-title: Clin. Lung Cancer
  doi: 10.1016/j.cllc.2015.04.008
– volume: 599
  start-page: 76
  year: 2006
  ident: ref_261
  article-title: Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae
  publication-title: Mutat. Res. Mol. Mech. Mutagen.
  doi: 10.1016/j.mrfmmm.2006.01.007
– volume: 45
  start-page: 6108
  year: 2016
  ident: ref_23
  article-title: A practical guide to working with H2S at the interface of chemistry and biology
  publication-title: Chem. Soc. Rev.
  doi: 10.1039/C6CS00212A
– volume: 279
  start-page: 49199
  year: 2004
  ident: ref_48
  article-title: Cystathionine γ-lyase overexpression inhibits cell proliferation via a H2-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M408997200
– volume: 6
  start-page: 1013
  year: 2007
  ident: ref_276
  article-title: Sulforaphane induces cell type–specific apoptosis in human breast cancer cell lines
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-06-0494
– volume: 18
  start-page: 947
  year: 2019
  ident: ref_376
  article-title: Distribution and Activity of Lenvatinib in Brain Tumor Models of Human Anaplastic Thyroid Cancer Cells in Severe Combined Immune Deficient Mice
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-18-0695
– ident: ref_218
  doi: 10.3390/nu11020295
– volume: 67
  start-page: 647
  year: 2015
  ident: ref_49
  article-title: Hydrogen sulfide in pharmacology and medicine–An update
  publication-title: Pharmacol. Rep.
  doi: 10.1016/j.pharep.2015.01.005
– ident: ref_119
  doi: 10.1186/s12885-018-4508-1
– volume: 38
  start-page: 101675
  year: 2021
  ident: ref_31
  article-title: Hydrogen sulfide and DNA repair
  publication-title: Redox Biol.
  doi: 10.1016/j.redox.2020.101675
– volume: 53
  start-page: 25
  year: 2014
  ident: ref_198
  article-title: Upregulation of the ATR-CHEK1 pathway in oral squamous cell carcinomas
  publication-title: Genes Chromosom. Cancer
  doi: 10.1002/gcc.22115
– volume: 16
  start-page: 557
  year: 2008
  ident: ref_326
  article-title: Dermatological reactions to the multitargeted tyrosine kinase inhibitor sunitinib
  publication-title: Support. Care Cancer
  doi: 10.1007/s00520-008-0409-1
– volume: 20
  start-page: 805
  year: 2014
  ident: ref_62
  article-title: Hydrogen Sulfide and the Pathogenesis of Atherosclerosis
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2013.5324
– volume: 177
  start-page: 884
  year: 2020
  ident: ref_150
  article-title: Modulation of the functions of myeloid-derived suppressor cells: A new strategy of hydrogen sulfide anti-cancer effects
  publication-title: J. Cereb. Blood Flow Metab.
– volume: 141
  start-page: 318
  year: 2022
  ident: ref_223
  article-title: Hydrogen sulfide attenuates ferroptosis and stimulates autophagy by blocking mTOR signaling in sepsis-induced acute lung injury
  publication-title: Mol. Immunol.
  doi: 10.1016/j.molimm.2021.12.003
– volume: 85
  start-page: 689
  year: 2013
  ident: ref_52
  article-title: Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2012.10.019
– volume: 23
  start-page: 9408
  year: 2005
  ident: ref_146
  article-title: Targeting the Cell Cycle: A New Approach to Cancer Therapy
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2005.01.5594
– volume: 19
  start-page: 392
  year: 2021
  ident: ref_225
  article-title: Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer
  publication-title: J. Nanobiotechnol.
  doi: 10.1186/s12951-021-01069-y
– volume: 60
  start-page: 665
  year: 2012
  ident: ref_282
  article-title: Benzyl Isothiocyanate (BITC) Induces G2/M Phase Arrest and Apoptosis in Human Melanoma A375.S2 Cells through Reactive Oxygen Species (ROS) and both Mitochondria-Dependent and Death Receptor-Mediated Multiple Signaling Pathways
  publication-title: J. Agric. Food Chem.
  doi: 10.1021/jf204193v
– volume: 15
  start-page: 7229
  year: 2009
  ident: ref_365
  article-title: E7080, a Multi-Tyrosine Kinase Inhibitor, Suppresses the Progression of Malignant Pleural Mesothelioma with Different Proangiogenic Cytokine Production Profiles
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-09-1980
– volume: 41
  start-page: 113
  year: 2011
  ident: ref_69
  article-title: Hydrogen sulfide: Its production, release and functions
  publication-title: Amino Acids
  doi: 10.1007/s00726-010-0510-x
– volume: 283
  start-page: 22136
  year: 2008
  ident: ref_270
  article-title: Covalent binding to tubulin by isothiocyanates: A mechanism of cell growth arrest and apoptosis
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M802330200
– volume: 171
  start-page: 2099
  year: 2014
  ident: ref_86
  article-title: Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms
  publication-title: J. Cereb. Blood Flow Metab.
– volume: 285
  start-page: 17318
  year: 2010
  ident: ref_244
  article-title: Effects of Hydrogen Sulfide-releasing l-DOPA Derivatives on Glial Activation: Potential for treating Parkinson disease
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.115261
– volume: 7
  start-page: 5134
  year: 2017
  ident: ref_250
  article-title: Hydrogen sulfide acts as a double-edged sword in human hepatocellular carcinoma cells through EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-05457-z
– volume: 46
  start-page: 24
  year: 2007
  ident: ref_266
  article-title: Dual action on promoter demethylation and chromatin by an isothiocyanate restored GSTP1 silenced in prostate cancer
  publication-title: Mol. Carcinog.
  doi: 10.1002/mc.20258
– volume: 12
  start-page: 125
  year: 2014
  ident: ref_145
  article-title: Cell division in apicomplexan parasites
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrmicro3184
– volume: 28
  start-page: 437
  year: 2021
  ident: ref_27
  article-title: Molecular Functions of Hydrogen Sulfide in Cancer
  publication-title: Pathophysiology
  doi: 10.3390/pathophysiology28030028
– volume: 34
  start-page: 2901
  year: 2015
  ident: ref_274
  article-title: Isothiocyanates inhibit the invasion and migration of C6 glioma cells by blocking FAK/JNK-mediated MMP-9 expression
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2015.4292
– volume: 763
  start-page: 10
  year: 2014
  ident: ref_105
  article-title: Hydrogen sulfide (H2)/cystathionine γ-lyase (CSE) pathway contributes to the proliferation of hepatoma cells
  publication-title: Mutat. Res./Fundam. Mol. Mech. Mutagen.
  doi: 10.1016/j.mrfmmm.2014.03.002
– volume: 13
  start-page: 1763
  year: 2010
  ident: ref_229
  article-title: Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2009.3074
– volume: 39
  start-page: 432
  year: 2019
  ident: ref_121
  article-title: Hydrogen sulfide attenuates paraquat—Induced epithelial-mesenchymal transition of human alveolar epithelial cells through regulating transforming growth factor—β1/Smad2/3 signaling pathway
  publication-title: J. Appl. Toxicol.
  doi: 10.1002/jat.3734
– volume: 41
  start-page: 302
  year: 2017
  ident: ref_202
  article-title: Targeting ATR in cancer medicine
  publication-title: Curr. Probl. Cancer
  doi: 10.1016/j.currproblcancer.2017.05.002
– volume: 3
  start-page: 1353
  year: 2014
  ident: ref_359
  article-title: Fatigue in patients with advanced renal cell carcinoma receiving sunitinib on an intermittent versus continuous dosing schedule in a randomized phase II trial
  publication-title: Cancer Med.
  doi: 10.1002/cam4.286
– volume: 90
  start-page: 135
  year: 2013
  ident: ref_37
  article-title: Hydrogen sulphide vasodilates human pulmonary arteries: A possible role in pulmonary hypertension?
  publication-title: Microvasc. Res.
  doi: 10.1016/j.mvr.2013.09.002
– volume: 177
  start-page: 866
  year: 2020
  ident: ref_130
  article-title: 3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics
  publication-title: J. Cereb. Blood Flow Metab.
– volume: 34
  start-page: 1284
  year: 2013
  ident: ref_246
  article-title: Hydrogen sulfide and translational medicine
  publication-title: Acta Pharmacol. Sin.
  doi: 10.1038/aps.2013.127
– volume: 71
  start-page: 431
  year: 2012
  ident: ref_349
  article-title: Incidence and risk of hypertension with pazopanib in patients with cancer: A meta-analysis
  publication-title: Cancer Chemother. Pharmacol.
  doi: 10.1007/s00280-012-2025-5
– volume: 46
  start-page: 129
  year: 2015
  ident: ref_388
  article-title: New biomarkers in serum and urine for detection of prostate cancer
  publication-title: Aktuelle Urol.
  doi: 10.1055/s-0034-1398544
– volume: 11
  start-page: 1818
  year: 2018
  ident: ref_184
  article-title: Expression of hydrogen sulfide synthases and Hh signaling pathway components correlate with the clinicopathological characteristics of papillary thyroid cancer patients
  publication-title: Int. J. Clin. Exp. Pathol.
– volume: 15
  start-page: 8225
  year: 2014
  ident: ref_313
  article-title: Potential Mechanisms of Benzyl Isothiocyanate Suppression of Invasion and Angiogenesis by the U87MG Human Glioma Cell Line
  publication-title: Asian Pac. J. Cancer Prev.
  doi: 10.7314/APJCP.2014.15.19.8225
– volume: 21
  start-page: 6848
  year: 2002
  ident: ref_91
  article-title: Comparison of gene expression profiling between malignant and normal plasma cells with oligonucleotide arrays
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1205868
– volume: 41
  start-page: 151
  year: 2011
  ident: ref_114
  article-title: The expression and activity of cystathionine-γ-lyase and 3-mercaptopyruvate sulfurtransferase in human neoplastic cell lines
  publication-title: Amino Acids
  doi: 10.1007/s00726-010-0606-3
– volume: 277
  start-page: 121103
  year: 2021
  ident: ref_227
  article-title: Multifaceted roles of a bioengineered nanoreactor in repressing radiation-induced lung injury
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2021.121103
– volume: 149
  start-page: 1060
  year: 2012
  ident: ref_208
  article-title: Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
  publication-title: Cell
  doi: 10.1016/j.cell.2012.03.042
– volume: 23
  start-page: 461
  year: 2021
  ident: ref_216
  article-title: Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells
  publication-title: Neoplasia
  doi: 10.1016/j.neo.2021.03.009
– volume: 9
  start-page: 569
  year: 2015
  ident: ref_200
  article-title: Untangling the ATR-CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer
  publication-title: Mol. Oncol.
  doi: 10.1016/j.molonc.2014.10.013
– volume: 133
  start-page: 15
  year: 2011
  ident: ref_231
  article-title: Cysteine-activated hydrogen sulfide (H2) donors
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja1085723
– volume: 20
  start-page: 1070
  year: 2019
  ident: ref_325
  article-title: Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): A randomised, multicentre, open-label, phase 2 study
  publication-title: Lancet Oncol.
  doi: 10.1016/S1470-2045(19)30272-4
– volume: 396
  start-page: 1247
  year: 2015
  ident: ref_311
  article-title: Exogenous hydrogen sulfide exhibits anti-cancer effects though p38 MAPK signaling pathway in C6 glioma cells
  publication-title: Biol. Chem.
  doi: 10.1515/hsz-2015-0148
– volume: 24
  start-page: e450
  year: 2019
  ident: ref_336
  article-title: Large-Scale, Prospective Observational Study of Regorafenib in Japanese Patients with Metastatic Colorectal Cancer in a Real-World Clinical Setting
  publication-title: Oncologist
  doi: 10.1634/theoncologist.2018-0377
– volume: 106
  start-page: 61
  year: 2019
  ident: ref_373
  article-title: Impact of dose interruption on the efficacy of lenvatinib in a phase 3 study in patients with radioiodine-refractory differentiated thyroid cancer
  publication-title: Eur. J. Cancer
  doi: 10.1016/j.ejca.2018.10.002
– volume: 230
  start-page: 243
  year: 2015
  ident: ref_299
  article-title: Role of H2S donors in cancer biology
  publication-title: Chem. Biochem. Pharmacol. Hydrog. Sulfide
  doi: 10.1007/978-3-319-18144-8_13
– volume: 18
  start-page: 1906
  year: 2013
  ident: ref_144
  article-title: Hydrogen Sulfide Protects Against Cellular Senescence via S-Sulfhydration of Keap1 and Activation of Nrf2
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2012.4645
– volume: 8
  start-page: 763
  year: 2017
  ident: ref_300
  article-title: Intracellular Hyper-Acidification Potentiated by Hydrogen Sulfide Mediates Invasive and Therapy Resistant Cancer Cell Death
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2017.00763
– volume: 25
  start-page: 1290
  year: 2014
  ident: ref_239
  article-title: Design and Synthesis of Polymeric Hydrogen Sulfide Donors
  publication-title: Bioconjug. Chem.
  doi: 10.1021/bc500150s
– volume: 20
  start-page: 252
  year: 1997
  ident: ref_193
  article-title: NF-kB: A crucial transcription factor for glial and neuronal cell function
  publication-title: Trends Neurosci.
  doi: 10.1016/S0166-2236(96)01035-1
– volume: 182
  start-page: 114267
  year: 2020
  ident: ref_84
  article-title: Mechanism of cystathionine-β-synthase inhibition by disulfiram: The role of bis (N, N-diethyldithiocarbamate)-copper (II)
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2020.114267
– volume: 12
  start-page: 1147
  year: 2010
  ident: ref_179
  article-title: The Effect of Hydrogen Sulfide Donors on Lipopolysaccharide-Induced Formation of Inflammatory Mediators in Macrophages
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2009.2899
– volume: 7
  start-page: 40070
  year: 2017
  ident: ref_294
  article-title: Benzyl Isothiocyanate potentiates p53 signaling and antitumor effects against breast cancer through activation of p53-LKB1 and p73-LKB1 axes
  publication-title: Sci. Rep.
  doi: 10.1038/srep40070
– volume: 7
  start-page: 455
  year: 2017
  ident: ref_137
  article-title: Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF-κB signaling pathways
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-00557-2
– volume: 48
  start-page: 1263
  year: 2010
  ident: ref_380
  article-title: Modulation of thiol homeostasis induced by H2-releasing aspirin
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2010.02.014
– volume: 51
  start-page: 832
  year: 2017
  ident: ref_283
  article-title: Benzyl isothiocyanate and phenethyl isothiocyanate inhibit murine melanoma B16F10 cell migration and invasion in vitro
  publication-title: Int. J. Oncol.
  doi: 10.3892/ijo.2017.4084
– volume: 10
  start-page: 79
  year: 2022
  ident: ref_221
  article-title: Ferroptosis due to Cystathionine γ Lyase/Hydrogen Sulfide Downregulation Under High Hydrostatic Pressure Exacerbates VSMC Dysfunction
  publication-title: Front. Cell Dev. Biol.
  doi: 10.3389/fcell.2022.829316
– volume: 35
  start-page: 5
  year: 2013
  ident: ref_66
  article-title: Hydrogen sulfide chemical biology: Pathophysiological roles and detection
  publication-title: Nitric Oxide
  doi: 10.1016/j.niox.2013.07.002
– volume: 106
  start-page: 1598
  year: 2012
  ident: ref_370
  article-title: A phase I study of E7080, a multitargeted tyrosine kinase inhibitor, in patients with advanced solid tumours
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.2012.154
– volume: 358
  start-page: 1142
  year: 2007
  ident: ref_167
  article-title: Hydrogen sulphide regulates intracellular pH in vascular smooth muscle cells
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2007.05.063
– volume: 8
  start-page: e2688
  year: 2017
  ident: ref_185
  article-title: Hydrogen sulfide promotes autophagy of hepatocellular carcinoma cells through the PI3K/Akt/mTOR signaling pathway
  publication-title: Cell Death Dis.
  doi: 10.1038/cddis.2017.18
– volume: 92
  start-page: 791
  year: 2012
  ident: ref_58
  article-title: Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00017.2011
– volume: 6
  start-page: 593
  year: 2013
  ident: ref_234
  article-title: Could hydrogen sulfide be the next blockbuster treatment for inflammatory disease?
  publication-title: Expert Rev. Clin. Pharmacol.
  doi: 10.1586/17512433.2013.842126
– volume: 51
  start-page: 1825
  year: 2013
  ident: ref_386
  article-title: Thiosulfate in urine as a facilitator in the diagnosis of prostate cancer for patients with prostate-specific antigen less or equal 10 ng/mL
  publication-title: Clin. Chem. Lab. Med. (CCLM)
  doi: 10.1515/cclm-2013-0069
– volume: 52
  start-page: e8409
  year: 2019
  ident: ref_317
  article-title: Benzyl isothiocyanate inhibits invasion and induces apoptosis via reducing S100A4 expression and increases PUMA expression in oral squamous cell carcinoma cells
  publication-title: Braz. J. Med. Biol. Res.
  doi: 10.1590/1414-431x20198409
– volume: 32
  start-page: 96
  year: 2020
  ident: ref_243
  article-title: Activatable Small-Molecule Hydrogen Sulfide Donors
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2019.7841
– volume: 130
  start-page: 61
  year: 2010
  ident: ref_303
  article-title: Oral administration of benzyl-isothiocyanate inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice
  publication-title: Breast Cancer Res. Treat.
  doi: 10.1007/s10549-010-1299-8
– volume: 389
  start-page: 56
  year: 2017
  ident: ref_331
  article-title: Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): A randomised, double-blind, placebo-controlled, phase 3 trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(16)32453-9
– volume: 4
  start-page: 211
  year: 2016
  ident: ref_361
  article-title: A Phase I, Dose-Escalation Trial of Pazopanib in Combination with Cisplatin in Patients with Advanced Solid Tumors: A UNICANCER Study
  publication-title: Oncol. Ther.
  doi: 10.1007/s40487-016-0027-x
– volume: 33
  start-page: 845
  year: 2019
  ident: ref_251
  article-title: Anticancer properties of erucin, an H2-releasing isothiocyanate, on human pancreatic adenocarcinoma cells (AsPC-1)
  publication-title: Phytother. Res.
  doi: 10.1002/ptr.6278
– ident: ref_316
  doi: 10.3390/molecules23112966
– volume: 11
  start-page: 88
  year: 2020
  ident: ref_211
  article-title: Ferroptosis: Past, present and future
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-020-2298-2
– volume: 35
  start-page: 47
  year: 2020
  ident: ref_296
  article-title: Benzyl isothiocyanate promotes miR-99a expression through ERK/AP-1-dependent pathway in bladder cancer cells
  publication-title: Environ. Toxicol.
  doi: 10.1002/tox.22841
– volume: 64
  start-page: 5767
  year: 2004
  ident: ref_264
  article-title: A novel mechanism of chemoprotection by sulforaphane: Inhibition of histone deacetylase
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-04-1326
– volume: 12
  start-page: 1
  year: 2010
  ident: ref_219
  article-title: Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2008.2282
– volume: 35
  start-page: 3551
  year: 2017
  ident: ref_333
  article-title: Hand-foot skin reaction (HFSR) and outcomes in the phase 3 CORRECT trial of regorafenib for metastatic colorectal cancer (mCRC)
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2017.35.15_suppl.3551
– volume: 30
  start-page: 871
  year: 2012
  ident: ref_343
  article-title: Meta-Analysis of Randomized Controlled Trials for the Incidence and Risk of Treatment-Related Mortality in Patients with Cancer Treated with Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitors
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2011.37.1195
– volume: 37
  start-page: 510
  year: 2012
  ident: ref_320
  article-title: Differentiating among incretin therapies: A multiple-target approach to type 2 diabetes
  publication-title: J. Clin. Pharm. Ther.
  doi: 10.1111/j.1365-2710.2012.01342.x
– volume: 100
  start-page: 1630
  year: 2019
  ident: ref_154
  article-title: Ovine uterine artery hydrogen sulfide biosynthesis in vivo: Effects of ovarian cycle and pregnancy
  publication-title: Biol. Reprod.
  doi: 10.1093/biolre/ioz027
– volume: 38
  start-page: 539
  year: 2017
  ident: ref_307
  article-title: Benzyl isothiocyanate induces protective autophagy in human lung cancer cells through an endoplasmic reticulum stress-mediated mechanism
  publication-title: Acta Pharmacol. Sin.
  doi: 10.1038/aps.2016.146
– volume: 25
  start-page: 110
  year: 2011
  ident: ref_180
  article-title: S-propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: Involvement of TNF signaling and NF-κB pathway in rats
  publication-title: Brain Behav. Immun.
  doi: 10.1016/j.bbi.2010.09.001
– volume: 41
  start-page: 2065
  year: 2012
  ident: ref_255
  article-title: ERK-modulated intrinsic signaling and G2/M phase arrest contribute to the induction of apoptotic death by allyl isothiocyanate in MDA-MB-468 human breast adenocarcinoma cells
  publication-title: Int. J. Oncol.
  doi: 10.3892/ijo.2012.1640
– volume: 52
  start-page: 622
  year: 2011
  ident: ref_97
  article-title: Hydrogen sulfide contributes to hypoxia-induced radioresistance on hepatoma cells
  publication-title: J. Radiat. Res.
  doi: 10.1269/jrr.11004
– volume: 78
  start-page: 109870
  year: 2021
  ident: ref_222
  article-title: Hydrogen sulfide guards myoblasts from ferroptosis by inhibiting ALOX12 acetylation
  publication-title: Cell. Signal.
  doi: 10.1016/j.cellsig.2020.109870
– volume: 18
  start-page: e117
  year: 2019
  ident: ref_323
  article-title: Third- or Later-line Therapy for Metastatic Colorectal Cancer: Reviewing Best Practice
  publication-title: Clin. Color. Cancer
  doi: 10.1016/j.clcc.2018.11.002
– ident: ref_78
  doi: 10.3390/cells8080828
– volume: 172
  start-page: 113775
  year: 2020
  ident: ref_29
  article-title: Hydrogen sulfide modulates epithelial-mesenchymal transition and angiogenesis in non-small cell lung cancer via HIF-1α activation
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2019.113775
– volume: 473
  start-page: 931
  year: 2016
  ident: ref_20
  article-title: Novel hydrogen sulfide-releasing compound, S-propargyl-cysteine, prevents STZ-induced diabetic nephropathy
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2016.03.154
– volume: 106
  start-page: 21972
  year: 2009
  ident: ref_134
  article-title: Hydrogen sulfide is an endogenous stimulator of angiogenesis
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0908047106
– volume: 66
  start-page: 92
  year: 2010
  ident: ref_168
  article-title: Hydrogen sulfide regulates intracellular pH in rat primary cultured glia cells
  publication-title: Neurosci. Res.
  doi: 10.1016/j.neures.2009.09.1713
– volume: 1491
  start-page: 188
  year: 2013
  ident: ref_139
  article-title: Exogenous hydrogen sulfide protects against global cerebral ischemia/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2012.10.046
– ident: ref_324
  doi: 10.1007/s11030-022-10406-8
– volume: 200
  start-page: 475
  year: 2013
  ident: ref_354
  article-title: Complications of Targeted Drug Therapies for Solid Malignancies: Manifestations and Mechanisms
  publication-title: Am. J. Roentgenol.
  doi: 10.2214/AJR.12.9049
– volume: 23
  start-page: 1254
  year: 2017
  ident: ref_372
  article-title: Optimizing Lenvatinib Therapy in Patients with Metastatic Radioactive Iodine-resistant Differentiated Thyroid Cancers
  publication-title: Endocr. Pract.
  doi: 10.4158/EP171822.OR
– volume: 41
  start-page: 1020
  year: 2016
  ident: ref_53
  article-title: Pharmacological Actions of Hydrogen Sulfide Donors on Sympathetic Neurotransmission in the Bovine Anterior Uvea, In Vitro
  publication-title: Neurochem. Res.
  doi: 10.1007/s11064-015-1784-x
– volume: 33
  start-page: 1097
  year: 2018
  ident: ref_293
  article-title: Benzyl isothiocyanate inhibits human brain glioblastoma multiforme GBM 8401 cell xenograft tumor in nude mice in vivo
  publication-title: Environ. Toxicol.
  doi: 10.1002/tox.22581
– volume: 12
  start-page: 1155
  year: 2010
  ident: ref_232
  article-title: Protective Effects of Cysteine Analogues on Acute Myocardial Ischemia: Novel Modulators of Endogenous H2 Production
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2009.2947
– volume: 5
  start-page: 287
  year: 2006
  ident: ref_301
  article-title: Benzyl isothiocyanate (BITC) induces apoptosis in ovarian cancer cells in vitro
  publication-title: J. Exp. Ther. Oncol.
– volume: 47
  start-page: 103
  year: 2009
  ident: ref_235
  article-title: GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2009.04.014
– volume: 34
  start-page: 166.e15
  year: 2016
  ident: ref_113
  article-title: Expression profile of hydrogen sulfide and its synthases correlates with tumor stage and grade in urothelial cell carcinoma of bladder
  publication-title: Urol. Oncol. Semin. Orig. Investig.
– volume: 45
  start-page: 13
  year: 2012
  ident: ref_143
  article-title: Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2011.10.021
– volume: 88
  start-page: 4393
  year: 2005
  ident: ref_237
  article-title: Effect of Garlic Oil and Four of its Compounds on Rumen Microbial Fermentation
  publication-title: J. Dairy Sci.
  doi: 10.3168/jds.S0022-0302(05)73126-X
– volume: 76
  start-page: 1153
  year: 2015
  ident: ref_369
  article-title: A phase 1 study of lenvatinib, multiple receptor tyrosine kinase inhibitor, in Japanese patients with advanced solid tumors
  publication-title: Cancer Chemother. Pharmacol.
  doi: 10.1007/s00280-015-2899-0
– volume: 257
  start-page: 420
  year: 2011
  ident: ref_107
  article-title: Hydrogen sulfide mediates the anti-survival effect of sulforaphane on human prostate cancer cells
  publication-title: Toxicol. Appl. Pharmacol.
  doi: 10.1016/j.taap.2011.09.026
– volume: 278
  start-page: 119551
  year: 2021
  ident: ref_217
  article-title: Hydrogen sulfide alleviates the anxiety-like and depressive-like behaviors of type 1 diabetic mice via inhibiting inflammation and ferroptosis
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2021.119551
– volume: 381
  start-page: 303
  year: 2013
  ident: ref_322
  article-title: Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): An international, multicentre, randomised, placebo-controlled, phase 3 trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(12)61900-X
– ident: ref_387
  doi: 10.1371/journal.pone.0022486
– ident: ref_151
  doi: 10.3390/cells10020220
– volume: 110
  start-page: 1
  year: 2016
  ident: ref_297
  article-title: Anticancer activity of glucomoringin isothiocyanate in human malignant astrocytoma cells
  publication-title: Fitoterapia
  doi: 10.1016/j.fitote.2016.02.007
– volume: 39
  start-page: 199
  year: 2013
  ident: ref_352
  article-title: Risk of tyrosine kinase inhibitors-induced hepatotoxicity in cancer patients: A meta-analysis
  publication-title: Cancer Treat. Rev.
  doi: 10.1016/j.ctrv.2012.09.004
– volume: 285
  start-page: 18225
  year: 2010
  ident: ref_96
  article-title: Ischemia/Reperfusion Reduces Transcription Factor Sp1-mediated Cystathionine β-Synthase Expression in the Kidney
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.132142
– volume: 38
  start-page: 3843
  year: 2018
  ident: ref_124
  article-title: Hydrogen Sulfide Is Increased in Oral Squamous Cell Carcinoma Compared to Adjacent Benign Oral Mucosae
  publication-title: Anticancer Res.
  doi: 10.21873/anticanres.12668
– volume: 16
  start-page: 1
  year: 2016
  ident: ref_335
  article-title: Survival, safety, and prognostic factors for outcome with Regorafenib in patients with metastatic colorectal cancer refractory to standard therapies: Results from a multicenter study (REBECCA) nested within a compassionate use program
  publication-title: BMC Cancer
– ident: ref_201
  doi: 10.1177/1758835920982853
– volume: 17
  start-page: 73
  year: 2021
  ident: ref_7
  article-title: Role of hydrogen sulfide donors in cancer development and progression
  publication-title: Int. J. Biol. Sci.
  doi: 10.7150/ijbs.47850
– volume: 10
  start-page: 252
  year: 2020
  ident: ref_30
  article-title: Hydrogen Sulfide Mediates Tumor Cell Resistance to Thioredoxin Inhibitor
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2020.00252
– ident: ref_161
  doi: 10.1186/s12885-021-07833-5
– volume: 15
  start-page: 8484
  year: 2018
  ident: ref_120
  article-title: Increased H2 and its synthases in urothelial cell carcinoma of the bladder, and enhanced cisplatin-induced apoptosis following H2 inhibition in EJ cells
  publication-title: Oncol. Lett.
– volume: 3
  start-page: e44
  year: 2016
  ident: ref_279
  article-title: 44 Allyl isothiocyanate induces reactive oxygen species-mediated autophagy through beclin-1 in human prostate cancer cells
  publication-title: Eur. Urol. Suppl.
  doi: 10.1016/S1569-9056(16)60046-5
– volume: 10
  start-page: 341
  year: 2014
  ident: ref_302
  article-title: Inhibition of invasion and epithelial-mesenchymal transition of human breast cancer cells by hydrogen sulfide through decreased phospho-p38 expression
  publication-title: Mol. Med. Rep.
  doi: 10.3892/mmr.2014.2161
– volume: 65
  start-page: 1554
  year: 2005
  ident: ref_93
  article-title: Expression Profiling of Homocysteine Junction Enzymes in the NCI60 Panel of Human Cancer Cell Lines
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-04-1554
– volume: 9
  start-page: 327
  year: 2012
  ident: ref_356
  article-title: Treatment selection in metastatic renal cell carcinoma: Expert consensus
  publication-title: Nat. Rev. Clin. Oncol.
  doi: 10.1038/nrclinonc.2012.59
– volume: 149
  start-page: 110
  year: 2018
  ident: ref_2
  article-title: A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2017.11.014
– volume: 14
  start-page: 329
  year: 2015
  ident: ref_56
  article-title: Hydrogen sulfide-based therapeutics: Exploiting a unique but ubiquitous gasotransmitter
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd4433
– volume: 19
  start-page: 669
  year: 2014
  ident: ref_330
  article-title: Optimizing Treatment Outcomes with Regorafenib: Personalized Dosing and Other Strategies to Support Patient Care
  publication-title: Oncologist
  doi: 10.1634/theoncologist.2013-0059
– volume: 38
  start-page: 5165
  year: 2018
  ident: ref_308
  article-title: Benzyl Isothiocyanate Induces Apoptotic Cell Death through Mitochondria-dependent Pathway in Gefitinib-resistant NCI-H460 Human Lung Cancer Cells In Vitro
  publication-title: Anticancer Res.
  doi: 10.21873/anticanres.12839
– volume: 230
  start-page: 233
  year: 2015
  ident: ref_100
  article-title: Hydrogen sulfide and cancer
  publication-title: Chem. Biochem. Pharmacol. Hydrog. Sulfide
  doi: 10.1007/978-3-319-18144-8_12
– ident: ref_98
  doi: 10.1371/journal.pone.0049683
– volume: 27
  start-page: 811
  year: 2006
  ident: ref_265
  article-title: Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgi265
– volume: 7
  start-page: 10924
  year: 2017
  ident: ref_4
  article-title: GYY4137, a Hydrogen Sulfide Donor Modulates miR194-Dependent Collagen Realignment in Diabetic Kidney
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-11256-3
– volume: 25
  start-page: 107
  year: 1993
  ident: ref_128
  article-title: Transamination and transsulphuration of l-cysteine in ehrlich ascites tumor cells and mouse liver: The nonenzymatic reaction of l-cysteine with pyruvate
  publication-title: Int. J. Biochem.
  doi: 10.1016/0020-711X(93)90496-2
– ident: ref_40
  doi: 10.1371/journal.pone.0020525
– volume: 73
  start-page: 181
  year: 2014
  ident: ref_371
  article-title: A phase 1b clinical trial of the multi-targeted tyrosine kinase inhibitor lenvatinib (E7080) in combination with everolimus for treatment of metastatic renal cell carcinoma (RCC)
  publication-title: Cancer Chemother. Pharmacol.
  doi: 10.1007/s00280-013-2339-y
– volume: 50
  start-page: 213
  year: 2009
  ident: ref_177
  article-title: Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds
  publication-title: Environ. Mol. Mutagen.
  doi: 10.1002/em.20454
– volume: 12
  start-page: 191
  year: 2012
  ident: ref_346
  article-title: Cardiac Toxicity of Targeted Therapies Used in the Treatment for Solid Tumours: A Review
  publication-title: Cardiovasc. Toxicol.
  doi: 10.1007/s12012-012-9164-0
– volume: 84
  start-page: 9550
  year: 2012
  ident: ref_383
  article-title: Selected Ion Flow Tube-MS Analysis of Headspace Vapor from Gastric Content for the Diagnosis of Gastro-Esophageal Cancer
  publication-title: Anal. Chem.
  doi: 10.1021/ac302409a
– volume: 50
  start-page: 38
  year: 2015
  ident: ref_248
  article-title: Hydrogen sulfide in cancer: Friend or foe?
  publication-title: Nitric Oxide
  doi: 10.1016/j.niox.2015.08.004
– volume: 7
  start-page: 299
  year: 2011
  ident: ref_348
  article-title: Molecular Mechanisms of Hypertension and Heart Failure Due to Antiangiogenic Cancer Therapies
  publication-title: Hear. Fail. Clin.
  doi: 10.1016/j.hfc.2011.03.004
– volume: 16
  start-page: 619
  year: 2015
  ident: ref_332
  article-title: Regorafenib plus best supportive care versus placebo plus best supportive care in Asian patients with previously treated metastatic colorectal cancer (CONCUR): A randomised, double-blind, placebo-controlled, phase 3 trial
  publication-title: Lancet Oncol.
  doi: 10.1016/S1470-2045(15)70156-7
– volume: 98
  start-page: e14774
  year: 2019
  ident: ref_374
  article-title: Efficacy and tolerability of initial low-dose lenvatinib to treat differentiated thyroid cancer
  publication-title: Medicine
  doi: 10.1097/MD.0000000000014774
– volume: 7
  start-page: 385
  year: 2016
  ident: ref_381
  article-title: The Role of Hydrogen Sulfide in Renal System
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2016.00385
– volume: 7
  start-page: 1947
  year: 2015
  ident: ref_199
  article-title: ATR-Chk1 signaling inhibition as a therapeutic strategy to enhance cisplatin chemosensitivity in urothelial bladder cancer
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.6482
– ident: ref_205
  doi: 10.3390/biology10020083
– volume: 265
  start-page: 78
  year: 2017
  ident: ref_16
  article-title: Hydrogen sulfide attenuates calcification of vascular smooth muscle cells via KEAP1/NRF2/NQO1 activation
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2017.08.012
– volume: 117
  start-page: 2351
  year: 2008
  ident: ref_236
  article-title: Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137)
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.107.753467
– volume: 134
  start-page: 2004
  year: 2004
  ident: ref_275
  article-title: Dietary Isothiocyanates Inhibit the Growth of Human Bladder Carcinoma Cells
  publication-title: J. Nutr.
  doi: 10.1093/jn/134.8.2004
– ident: ref_1
  doi: 10.3390/biom10020323
– volume: 9
  start-page: 667
  year: 2004
  ident: ref_149
  article-title: PI3K-Akt pathway: Its functions and alterations in human cancer
  publication-title: Apoptosis
  doi: 10.1023/B:APPT.0000045801.15585.dd
– volume: 36
  start-page: 1909
  year: 2016
  ident: ref_187
  article-title: Exogenous hydrogen sulfide exerts proliferation, anti-apoptosis, migration effects and accelerates cell cycle progression in multiple myeloma cells via activating the Akt pathway
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2016.5014
– ident: ref_214
  doi: 10.3390/biom11060896
– volume: 32
  start-page: 359
  year: 2010
  ident: ref_304
  article-title: Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgq267
– volume: 60
  start-page: 195
  year: 2013
  ident: ref_59
  article-title: Microbial regulation of host hydrogen sulfide bioavailability and metabolism
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2013.02.024
– volume: 22
  start-page: 1
  year: 2021
  ident: ref_213
  article-title: Iron regulatory protein 1 promotes ferroptosis by sustaining cellular iron homeostasis in melanoma
  publication-title: Oncol. Lett.
  doi: 10.3892/ol.2021.12918
– volume: 12
  start-page: 1203
  year: 2010
  ident: ref_42
  article-title: Novel Insights into Hydrogen Sulfide–Mediated Cytoprotection
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2009.2882
– volume: 16
  start-page: 55
  year: 1960
  ident: ref_127
  article-title: The rate of cleavage of β-mercaptopyruvate by rapidly dividing cells
  publication-title: Experientia
  doi: 10.1007/BF02170255
– volume: 134
  start-page: 2229
  year: 2004
  ident: ref_272
  article-title: Sulforaphane Inhibits Human MCF-7 Mammary Cancer Cell Mitotic Progression and Tubulin Polymerization
  publication-title: J. Nutr.
  doi: 10.1093/jn/134.9.2229
– volume: 15
  start-page: 373
  year: 2011
  ident: ref_47
  article-title: Free and acid-labile hydrogen sulfide concentrations in mouse tissues: Anomalously high free hydrogen sulfide in aortic tissue
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2010.3525
– volume: 34
  start-page: 101564
  year: 2020
  ident: ref_152
  article-title: Hydrogen sulfide and its donors: Novel antitumor and antimetastatic therapies for triple-negative breast cancer
  publication-title: Redox Biol.
  doi: 10.1016/j.redox.2020.101564
– volume: Volume 1219
  start-page: 335
  year: 2020
  ident: ref_77
  article-title: Hydrogen Sulfide Metabolism and Signaling in the Tumor Microenvironment
  publication-title: Advances in Experimental Medicine and Biology
  doi: 10.1007/978-3-030-34025-4_17
– volume: 43
  start-page: 692
  year: 2018
  ident: ref_50
  article-title: Comparative Effects of Hydrogen Sulfide-Releasing Compounds on [3H]D-Aspartate Release from Bovine Isolated Retinae
  publication-title: Neurochem. Res.
  doi: 10.1007/s11064-018-2471-5
– volume: 26
  start-page: 2801
  year: 2014
  ident: ref_103
  article-title: Wnt/β-catenin signaling induces the transcription of cystathionine-γ-lyase, a stimulator of tumor in colon cancer
  publication-title: Cell. Signal.
  doi: 10.1016/j.cellsig.2014.08.023
– volume: 2
  start-page: ra72
  year: 2009
  ident: ref_101
  article-title: H2S signals through protein S-sulfhydration
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.2000464
– volume: 8
  start-page: 227
  year: 2016
  ident: ref_191
  article-title: Signaling via the NFκB system
  publication-title: Wiley Interdiscip. Rev. Syst. Biol. Med.
  doi: 10.1002/wsbm.1331
– volume: 34
  start-page: 2413
  year: 2015
  ident: ref_312
  article-title: Exogenous hydrogen sulfide promotes C6 glioma cell growth through activation of the p38 MAPK/ERK1/2-COX-2 pathways
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2015.4248
– volume: 286
  start-page: 39848
  year: 2011
  ident: ref_183
  article-title: Hydrogen sulfide and L-cysteine increase phosphatidylinositol 3, 4, 5-trisphosphate (PIP3) and glucose utilization by inhibiting phosphatase and tensin homolog (PTEN) protein and activating phosphoinositide 3-kinase (PI3K)/serine/threonine protein kinase (AKT)/protein kinase Cζ/λ (PKCζ/λ) in 3T3l1 adipocytes
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.270884
– volume: 34
  start-page: 91
  year: 1995
  ident: ref_319
  article-title: Some practical considerations and applications of the national cancer institute in vitro anticancer drug discovery screen
  publication-title: Drug Dev. Res.
  doi: 10.1002/ddr.430340203
– volume: 175
  start-page: 577
  year: 2018
  ident: ref_131
  article-title: Multiple role of 3-mercaptopyruvate sulfurtransferase: Antioxidative function, H2 and polysulfide production and possible SOx production
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/bph.14100
– volume: 12
  start-page: 237
  year: 2012
  ident: ref_321
  article-title: Combining immunotherapy and targeted therapies in cancer treatment
  publication-title: Nat. Cancer
  doi: 10.1038/nrc3237
– ident: ref_81
  doi: 10.3390/biom10030447
– volume: 21
  start-page: 1699
  year: 2007
  ident: ref_133
  article-title: Sulfide, the first inorganic substrate for human cells
  publication-title: FASEB J.
  doi: 10.1096/fj.06-7407com
– volume: 51
  start-page: 169
  year: 2011
  ident: ref_72
  article-title: Hydrogen sulfide and cell signaling
  publication-title: Annu. Rev. Pharmacol. Toxicol.
  doi: 10.1146/annurev-pharmtox-010510-100505
– ident: ref_71
  doi: 10.1007/978-3-319-18144-8_1
– volume: 28
  start-page: 61
  year: 2015
  ident: ref_89
  article-title: Role of the cystathionine γ lyase/hydrogen sulfide pathway in human melanoma progression
  publication-title: Pigment. Cell Melanoma Res.
  doi: 10.1111/pcmr.12312
– volume: 491
  start-page: 364
  year: 2012
  ident: ref_164
  article-title: How cancer metabolism is tuned for proliferation and vulnerable to disruption
  publication-title: Nature
  doi: 10.1038/nature11706
– volume: 11
  start-page: 564281
  year: 2020
  ident: ref_18
  article-title: Roles of Hydrogen Sulfide Donors in Common Kidney Diseases
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2020.564281
– volume: 149
  start-page: 174
  year: 2018
  ident: ref_118
  article-title: Drug resistance induces the upregulation of H2-producing enzymes in HCT116 colon cancer cells
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2017.10.007
– volume: 129
  start-page: 742
  year: 2011
  ident: ref_366
  article-title: Antitumour activity of oral E7080, a novel inhibitor of multiple tyrosine kinases, in human sarcoma xenografts
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.25922
– volume: 27
  start-page: 601
  year: 2013
  ident: ref_116
  article-title: Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics
  publication-title: FASEB J.
  doi: 10.1096/fj.12-216507
– volume: 20
  start-page: 783
  year: 2014
  ident: ref_63
  article-title: Production and Physiological Effects of Hydrogen Sulfide
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2013.5309
– volume: 219
  start-page: S132
  year: 2014
  ident: ref_102
  article-title: Aminooxyacetic Acid in Combination with Oxaliplatin Significantly Decreases Colorectal Liver Metastasis in vivo
  publication-title: J. Am. Coll. Surg.
  doi: 10.1016/j.jamcollsurg.2014.07.315
– volume: 9
  start-page: 501
  year: 2009
  ident: ref_178
  article-title: Apoptosis and cancer: The genesis of a research field
  publication-title: Nat. Cancer
  doi: 10.1038/nrc2663
– ident: ref_268
  doi: 10.1371/journal.pone.0025799
– volume: 17
  start-page: 141
  year: 2012
  ident: ref_136
  article-title: Hydrogen Sulfide in the Mammalian Cardiovascular System
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2011.4005
– volume: 45
  start-page: 1
  year: 2021
  ident: ref_153
  article-title: Therapeutic potential of endogenous hydrogen sulfide inhibition in breast cancer (Review)
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2021.8019
– volume: 294
  start-page: 12077
  year: 2019
  ident: ref_79
  article-title: Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.RA119.009442
– volume: 7
  start-page: 75749
  year: 2016
  ident: ref_289
  article-title: Alpha fetoprotein antagonises benzyl isothiocyanate inhibition of the malignant behaviors of hepatocellular carcinoma cells
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.12407
– volume: 28
  start-page: 501
  year: 2007
  ident: ref_38
  article-title: Hydrogen sulfide-releasing anti-inflammatory drugs
  publication-title: Trends Pharmacol. Sci.
  doi: 10.1016/j.tips.2007.09.003
– volume: 32
  start-page: 371
  year: 2016
  ident: ref_54
  article-title: Effect of Hydrogen Sulfide Donors on Intraocular Pressure in Rabbits
  publication-title: J. Ocul. Pharmacol. Ther.
  doi: 10.1089/jop.2015.0144
– volume: 51
  start-page: 102233
  year: 2022
  ident: ref_155
  article-title: Overproduction of hydrogen sulfide, generated by cystathionine β-synthase, disrupts brain wave patterns and contributes to neurobehavioral dysfunction in a rat model of down syndrome
  publication-title: Redox Biol.
  doi: 10.1016/j.redox.2022.102233
– volume: 24
  start-page: 1
  year: 2021
  ident: ref_206
  article-title: Ferroptosis: An iron-dependent cell death form linking metabolism, diseases, immune cell and targeted therapy
  publication-title: Clin. Transl. Oncol.
  doi: 10.1007/s12094-021-02669-8
– volume: 554
  start-page: 3
  year: 2015
  ident: ref_75
  article-title: Mechanistic Chemical Perspective of Hydrogen Sulfide Signaling
  publication-title: Methods Enzymol.
  doi: 10.1016/bs.mie.2014.11.036
– volume: 172
  start-page: 1516
  year: 2015
  ident: ref_110
  article-title: Interactions of hydrogen sulfide with myeloperoxidase
  publication-title: J. Cereb. Blood Flow Metab.
– volume: 261
  start-page: 118348
  year: 2020
  ident: ref_83
  article-title: Inhibition of endogenous hydrogen sulfide biosynthesis enhances the anti-cancer effect of 3,3′-diindolylmethane in human gastric cancer cells
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2020.118348
– volume: 39
  start-page: 2969
  year: 2018
  ident: ref_305
  article-title: Anticancer effect of exogenous hydrogen sulfide in cisplatin-resistant A549/DDP cells
  publication-title: Oncol. Rep.
– volume: 2015
  start-page: 1
  year: 2015
  ident: ref_378
  article-title: Hydrogen Sulfide Donor GYY4137 Protects against Myocardial Fibrosis
  publication-title: Oxidative Med. Cell. Longev.
  doi: 10.1155/2015/691070
– volume: 61
  start-page: 324
  year: 2010
  ident: ref_260
  article-title: Effects of phenylethyl isothiocyanate and its metabolite on cell-cycle arrest and apoptosis in LNCaP human prostate cancer cells
  publication-title: Int. J. Food Sci. Nutr.
  doi: 10.3109/09637481003639092
– volume: 19
  start-page: 21350
  year: 2014
  ident: ref_122
  article-title: Is development of high-grade gliomas sulfur-dependent?
  publication-title: Molecules
  doi: 10.3390/molecules191221350
– ident: ref_160
  doi: 10.3390/cells11030325
– volume: 11
  start-page: 3247
  year: 2018
  ident: ref_318
  article-title: Exogenous H2S promotes cancer progression by activating JAK2/STAT3 signaling pathway in esophageal EC109 cells
  publication-title: Int. J. Clin. Exp. Pathol.
– volume: 51
  start-page: 1
  year: 2019
  ident: ref_389
  article-title: Disturbed homocysteine metabolism is associated with cancer
  publication-title: Exp. Mol. Med.
  doi: 10.1038/s12276-019-0216-4
– volume: 11
  start-page: 8963
  year: 2021
  ident: ref_162
  article-title: A novel cystathionine γ-lyase inhibitor, I194496, inhibits the growth and metastasis of human TNBC via downregulating multiple signaling pathways
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-021-88355-9
– volume: 195
  start-page: 110464
  year: 2020
  ident: ref_306
  article-title: Exogenous hydrogen sulfide donor NaHS alleviates nickel-induced epithelial-mesenchymal transition and the migration of A549 cells by regulating TGF-β1/Smad2/Smad3 signaling
  publication-title: Ecotoxicol. Environ. Saf.
  doi: 10.1016/j.ecoenv.2020.110464
– volume: 109
  start-page: 1259
  year: 2011
  ident: ref_135
  article-title: Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.111.240242
– volume: 32
  start-page: 4145
  year: 2018
  ident: ref_189
  article-title: Cystathionine β-synthase regulates mitochondrial morphogenesis in ovarian cancer
  publication-title: FASEB J.
  doi: 10.1096/fj.201701095R
– volume: 67
  start-page: 612
  year: 2018
  ident: ref_338
  article-title: Complete response under sorafenib in patients with hepatocellular carcinoma: Relationship with dermatologic adverse events
  publication-title: Hepatology
  doi: 10.1002/hep.29515
– volume: 144
  start-page: 646
  year: 2011
  ident: ref_163
  article-title: Hallmarks of cancer: The next generation
  publication-title: Cell
  doi: 10.1016/j.cell.2011.02.013
– volume: 15
  start-page: 185
  year: 2015
  ident: ref_22
  article-title: Gasotransmitters in cancer: From pathophysiology to experimental therapy
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd.2015.1
– volume: 107
  start-page: 1047.e9
  year: 2017
  ident: ref_375
  article-title: Unusual Magnetic Resonance Imaging Findings of a Glioblastoma Arising During Treatment with Lenvatinib for Thyroid Cancer
  publication-title: World Neurosurg.
  doi: 10.1016/j.wneu.2017.08.017
– volume: 58
  start-page: 103
  year: 2010
  ident: ref_245
  article-title: Hydrogen sulfide-releasing NSAIDs attenuate neuroinflammation induced by microglial and astrocytic activation
  publication-title: Glia
  doi: 10.1002/glia.20905
– volume: 2019
  start-page: 3831713
  year: 2019
  ident: ref_61
  article-title: Hydrogen Sulfide as a Novel Regulatory Factor in Liver Health and Disease
  publication-title: Oxidative Med. Cell. Longev.
– volume: 171
  start-page: 4322
  year: 2014
  ident: ref_166
  article-title: Utilizing hydrogen sulfide as a novel anti-cancer agent by targeting cancer glycolysis and pH imbalance
  publication-title: J. Cereb. Blood Flow Metab.
– volume: 12
  start-page: 1398
  year: 2014
  ident: ref_99
  article-title: Decreased expression of cystathionine β-synthase promotes glioma tumorigenesis
  publication-title: Mol. Cancer Res.
  doi: 10.1158/1541-7786.MCR-14-0184
– volume: 110
  start-page: 12474
  year: 2013
  ident: ref_34
  article-title: Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1306241110
– volume: 1
  start-page: 1
  year: 2008
  ident: ref_278
  article-title: Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways
  publication-title: J. Hematol. Oncol.
  doi: 10.1186/1756-8722-1-6
– ident: ref_212
  doi: 10.3390/ijms22168898
– volume: 10
  start-page: 1945
  year: 2019
  ident: ref_390
  article-title: Dual-biomarker-triggered fluorescence probes for differentiating cancer cells and revealing synergistic antioxidant effects under oxidative stress
  publication-title: Chem. Sci.
  doi: 10.1039/C8SC03781G
– volume: 14
  start-page: 5459
  year: 2008
  ident: ref_364
  article-title: Multi-Kinase Inhibitor E7080 Suppresses Lymph Node and Lung Metastases of Human Mammary Breast Tumor MDA-MB-231 via Inhibition of Vascular Endothelial Growth Factor-Receptor (VEGF-R) 2 and VEGF-R3 Kinase
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-07-5270
– volume: 61
  start-page: 318
  year: 2014
  ident: ref_337
  article-title: Early dermatologic adverse events predict better outcome in HCC patients treated with sorafenib
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2014.03.030
– volume: 114
  start-page: 730
  year: 2014
  ident: ref_55
  article-title: Emergence of Hydrogen Sulfide as an Endogenous Gaseous Signaling Molecule in Cardiovascular Disease
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.114.300505
– volume: 35
  start-page: 2089
  year: 2016
  ident: ref_286
  article-title: Benzyl isothiocyanate alters the gene expression with cell cycle regulation and cell death in human brain glioblastoma GBM 8401 cells
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2016.4577
– volume: 80
  start-page: 1271
  year: 2011
  ident: ref_355
  article-title: Proteinuria and hypertension with tyrosine kinase inhibitors
  publication-title: Kidney Int.
  doi: 10.1038/ki.2011.288
– volume: 41
  start-page: 38
  year: 2014
  ident: ref_43
  article-title: Hydrogen sulfide and nitric oxide interactions in inflammation
  publication-title: Nitric Oxide
  doi: 10.1016/j.niox.2014.05.014
– volume: 4
  start-page: e515
  year: 2013
  ident: ref_288
  article-title: Downregulation of Mcl-1 through inhibition of translation contributes to benzyl isothiocyanate-induced cell cycle arrest and apoptosis in human leukemia cells
  publication-title: Cell Death Dis.
  doi: 10.1038/cddis.2013.41
– volume: 24
  start-page: 4486
  year: 2005
  ident: ref_267
  article-title: Suppression of NF-κB and NF-κB-regulated gene expression by sulforaphane and PEITC through IκBα, IKK pathway in human prostate cancer PC-3 cells
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1208656
– volume: 11
  start-page: 172
  year: 2013
  ident: ref_341
  article-title: Understanding and managing toxicities of vascular endothelial growth factor (VEGF) inhibitors
  publication-title: Eur. J. Cancer Suppl.
  doi: 10.1016/j.ejcsup.2013.07.016
– volume: 309
  start-page: C107
  year: 2015
  ident: ref_315
  article-title: Novel mechanism of hydrogen sulfide-induced guinea pig urinary bladder smooth muscle contraction: Role of BK channels and cholinergic neurotransmission
  publication-title: Am. J. Physiol. Physiol.
  doi: 10.1152/ajpcell.00021.2015
– volume: 34
  start-page: 565
  year: 2010
  ident: ref_104
  article-title: Hydrogen sulfide induces human colon cancer cell proliferation: Role of Akt, ERK and p21
  publication-title: Cell Biol. Int.
  doi: 10.1042/CBI20090368
– volume: 8
  start-page: 81
  year: 2012
  ident: ref_36
  article-title: Hydrogen Sulfide: Potent Regulator of Vascular Tone and Stimulator of Angiogenesis
  publication-title: Int. J. Biomed. Sci. IJBS
  doi: 10.59566/IJBS.2012.8081
– ident: ref_334
  doi: 10.1200/JCO.2018.36.4_suppl.412
– volume: 455
  start-page: 60
  year: 2019
  ident: ref_5
  article-title: A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2019.04.031
– volume: 11
  start-page: 3990
  year: 2005
  ident: ref_140
  article-title: Hydrogen sulfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocyanate induced apoptosis
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v11.i26.3990
– volume: 230
  start-page: 193
  year: 2015
  ident: ref_242
  article-title: Brain, learning, and memory: Role of H 2 S in neurodegenerative diseases
  publication-title: Chem. Biochem. Pharmacol. Hydrog. Sulfide
  doi: 10.1007/978-3-319-18144-8_10
– ident: ref_129
  doi: 10.3390/biom10040653
– volume: 31
  start-page: 1
  year: 2019
  ident: ref_32
  article-title: A review of hydrogen sulfide synthesis, metabolism, and measurement: Is modulation of hydrogen sulfide a novel therapeutic for cancer?
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2017.7058
– volume: 21
  start-page: 156
  year: 2014
  ident: ref_94
  article-title: Hydrogen sulfide accelerates cell cycle progression in oral squamous cell carcinoma cell lines
  publication-title: Oral Dis.
  doi: 10.1111/odi.12223
– volume: 165
  start-page: 105393
  year: 2021
  ident: ref_85
  article-title: Pharmacological induction of mesenchymal-epithelial transition via inhibition of H2 biosynthesis and consequent suppression of ACLY activity in colon cancer cells
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2020.105393
– ident: ref_339
  doi: 10.1371/journal.pone.0101145
– volume: 35
  start-page: 183
  year: 2017
  ident: ref_344
  article-title: The potential role of follicle-stimulating hormone in the cardiovascular, metabolic, skeletal, and cognitive effects associated with androgen deprivation therapy
  publication-title: Urol. Oncol. Semin. Orig. Investig.
– volume: 9
  start-page: 1005
  year: 2018
  ident: ref_224
  article-title: A pharmacological probe identifies cystathionine β-synthase as a new negative regulator for ferroptosis
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-018-1063-2
– volume: 5
  start-page: 2931
  year: 2006
  ident: ref_257
  article-title: Benzyl isothiocyanate–induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-06-0396
– volume: 9
  start-page: 1066
  year: 2018
  ident: ref_21
  article-title: Hydrogen Sulfide (H2S)-Releasing Compounds: Therapeutic Potential in Cardiovascular Diseases
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2018.01066
– volume: 11
  start-page: 585
  year: 2018
  ident: ref_126
  article-title: Hydrogen Sulfide and Hydrogen Sulfide-Synthesizing Enzymes Are Altered in a Case of Oral Adenoid Cystic Carcinoma
  publication-title: Case Rep. Oncol.
  doi: 10.1159/000492464
– volume: 3
  start-page: 718
  year: 2010
  ident: ref_287
  article-title: p53-Independent Apoptosis by Benzyl Isothiocyanate in Human Breast Cancer Cells Is Mediated by Suppression of XIAP Expression
  publication-title: Cancer Prev. Res.
  doi: 10.1158/1940-6207.CAPR-10-0048
– volume: 320
  start-page: 247
  year: 2014
  ident: ref_182
  article-title: Differential susceptibility to hydrogen sulfide-induced apoptosis between PHLDA1-overexpressing oral cancer cell lines and oral keratinocytes: Role of PHLDA1 as an apoptosis suppressor
  publication-title: Exp. Cell Res.
  doi: 10.1016/j.yexcr.2013.10.023
– volume: 104
  start-page: 262
  year: 2017
  ident: ref_138
  article-title: Hydrogen sulfide reduces RAGE toxicity through inhibition of its dimer formation
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2017.01.026
– volume: 322
  start-page: 587
  year: 2008
  ident: ref_108
  article-title: H2 as a physiologic vasorelaxant: Hypertension in mice with deletion of cystathionine γ-lyase
  publication-title: Science
  doi: 10.1126/science.1162667
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Snippet Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian tissues. It plays a very critical role in many pathophysiological...
Hydrogen sulfide (H S) is an endogenous biologically active gas produced in mammalian tissues. It plays a very critical role in many pathophysiological...
Hydrogen sulfide (H 2 S) is an endogenous biologically active gas produced in mammalian tissues. It plays a very critical role in many pathophysiological...
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StartPage 3389
SubjectTerms Angiogenesis
Animals
Biology
Biosynthesis
Brain research
Cancer
Cardiovascular system
Cell cycle
Colorectal cancer
Cysteine
DNA repair
endogenous gases
Enzymes
Glucose
Homocysteine
hydrogen sulfide
Hydrogen Sulfide - metabolism
Kidneys
Liver
Lungs
Mammals
Mammals - metabolism
Metabolism
Metastasis
Microbiota
Mitochondria
Neoplasms - drug therapy
Nervous system
Physiology
Review
Roles
Signal Transduction - physiology
signaling pathways
Small intestine
Sulfur
translational medicine
Uterus
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Title Hydrogen Sulfide Biology and Its Role in Cancer
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