Hydrogen Sulfide Biology and Its Role in Cancer

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 11; p. 3389
• Main Authors: Khattak, Saadullah, Rauf, Mohd Ahmar, Khan, Nazeer Hussain, Zhang, Qian-Qian, Chen, Hao-Jie, Muhammad, Pir, Ansari, Mohammad Azam, Alomary, Mohammad N., Jahangir, Muhammad, Zhang, Chun-Yang, Ji, Xin-Ying, Wu, Dong-Dong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.05.2022; MDPI
• Subjects: Angiogenesis; Animals; Biology; Biosynthesis; Brain research; Cancer; Cardiovascular system; Cell cycle; Colorectal cancer; Cysteine; DNA repair; endogenous gases; Enzymes; Glucose; Homocysteine; hydrogen sulfide; Hydrogen Sulfide - metabolism; Kidneys; Liver; Lungs; Mammals; Mammals - metabolism; Metabolism; Metastasis; Microbiota; Mitochondria; Neoplasms - drug therapy; Nervous system; Physiology; Review; Roles; Signal Transduction - physiology; signaling pathways; Small intestine; Sulfur; translational medicine; Uterus; endogenous gases; translational medicine; cancer; signaling pathways; hydrogen sulfide
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27113389

Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian tissues. It plays a very critical role in many pathophysiological processes in the body. It can be endogenously produced through many enzymes analogous to the cysteine family, while the exogenous source may involve inorganic sulfide salts. H2S has recently been well investigated with regard to the onset of various carcinogenic diseases such as lung, breast, ovaries, colon cancer, and neurodegenerative disorders. H2S is considered an oncogenic gas, and a potential therapeutic target for treating and diagnosing cancers, due to its role in mediating the development of tumorigenesis. Here in this review, an in-detail up-to-date explanation of the potential role of H2S in different malignancies has been reported. The study summarizes the synthesis of H2S, its roles, signaling routes, expressions, and H2S release in various malignancies. Considering the critical importance of this active biological molecule, we believe this review in this esteemed journal will highlight the oncogenic role of H2S in the scientific community.