Integration of detailed modules in a core model of body fluid homeostasis and blood pressure regulation

This paper presents a contribution to the definition of the interfaces required to perform heterogeneous model integration in the context of integrative physiology. A formalization of the model integration problem is proposed and a coupling method is presented. The extension of the classic Guyton mo...

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Published inProgress in biophysics and molecular biology Vol. 107; no. 1; pp. 169 - 182
Main Authors Hernández, Alfredo I., Le Rolle, Virginie, Ojeda, David, Baconnier, Pierre, Fontecave-Jallon, Julie, Guillaud, François, Grosse, Thibault, Moss, Robert G., Hannaert, Patrick, Thomas, S. Randall
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2011
Elsevier
Subjects
Bioengineering
Blood Circulation - physiology
blood pressure
Blood Pressure - physiology
Body Fluids - physiology
Cardiac function
Cardiovascular physiology
Computer Science
Endocrine System - physiology
Engineering Sciences
heart
Heart - physiology
Heterogeneous model coupling
homeostasis
Homeostasis - physiology
Humans
Kidney - physiology
Life Sciences
Model interactions
Modeling and Simulation
Models, Biological
Renin-Angiotensin System - physiology
Renin–angiotensin system
Signal and Image Processing
Systems Integration
Renin–angiotensin system
Heterogeneous model coupling
Model interactions
Cardiac function
Cardiovascular physiology
Renin-angiotensin system
Online AccessGet full text
ISSN0079-6107
1873-1732
1873-1732
DOI10.1016/j.pbiomolbio.2011.06.008

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Abstract This paper presents a contribution to the definition of the interfaces required to perform heterogeneous model integration in the context of integrative physiology. A formalization of the model integration problem is proposed and a coupling method is presented. The extension of the classic Guyton model, a multi-organ, integrated systems model of blood pressure regulation, is used as an example of the application of the proposed method. To this end, the Guyton model has been restructured, extensive sensitivity analyses have been performed, and appropriate transformations have been applied to replace a subset of its constituting modules by integrating a pulsatile heart and an updated representation of the renin–angiotensin system. Simulation results of the extended integrated model are presented and the impacts of their integration within the original model are evaluated.
AbstractList This paper presents a contribution to the definition of the interfaces required to perform heterogeneous model integration in the context of integrative physiology. A formalization of the model integration problem is proposed and a coupling method is presented. The extension of the classic Guyton model, a multi-organ, integrated systems model of blood pressure regulation, is used as an example of the application of the proposed method. To this end, the Guyton model has been restructured, extensive sensitivity analyses have been performed, and appropriate transformations have been applied to replace a subset of its constituting modules by integrating a pulsatile heart and an updated representation of the renin–angiotensin system. Simulation results of the extended integrated model are presented and the impacts of their integration within the original model are evaluated.
This paper presents a contribution to the definition of the interfaces required to perform heterogeneous model integration in the context of integrative physiology. A formalization of the model integration problem is proposed and a coupling method is presented. The extension of the classic Guyton model, a multi-organ, integrated systems model of blood pressure regulation, is used as an example of the application of the proposed method. To this end, the Guyton model has been restructured, extensive sensitivity analyses have been performed, and appropriate transformations have been applied to replace a subset of its constituting modules by integrating a pulsatile heart and an updated representation of the renin-angiotensin system. Simulation results of the extended integrated model are presented and the impacts of their integration within the original model are evaluated.This paper presents a contribution to the definition of the interfaces required to perform heterogeneous model integration in the context of integrative physiology. A formalization of the model integration problem is proposed and a coupling method is presented. The extension of the classic Guyton model, a multi-organ, integrated systems model of blood pressure regulation, is used as an example of the application of the proposed method. To this end, the Guyton model has been restructured, extensive sensitivity analyses have been performed, and appropriate transformations have been applied to replace a subset of its constituting modules by integrating a pulsatile heart and an updated representation of the renin-angiotensin system. Simulation results of the extended integrated model are presented and the impacts of their integration within the original model are evaluated.
Author Grosse, Thibault
Le Rolle, Virginie
Baconnier, Pierre
Fontecave-Jallon, Julie
Guillaud, François
Moss, Robert G.
Hannaert, Patrick
Thomas, S. Randall
Ojeda, David
Hernández, Alfredo I.
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Issue 1
Keywords Renin–angiotensin system
Heterogeneous model coupling
Model interactions
Cardiac function
Cardiovascular physiology
Renin-angiotensin system
Language English
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SSID ssj0002176
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Snippet This paper presents a contribution to the definition of the interfaces required to perform heterogeneous model integration in the context of integrative...
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SubjectTerms Bioengineering
Blood Circulation - physiology
blood pressure
Blood Pressure - physiology
Body Fluids - physiology
Cardiac function
Cardiovascular physiology
Computer Science
Endocrine System - physiology
Engineering Sciences
heart
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Heterogeneous model coupling
homeostasis
Homeostasis - physiology
Humans
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Life Sciences
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Title Integration of detailed modules in a core model of body fluid homeostasis and blood pressure regulation
URI https://dx.doi.org/10.1016/j.pbiomolbio.2011.06.008
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