Integration of detailed modules in a core model of body fluid homeostasis and blood pressure regulation

• Published in: Progress in biophysics and molecular biology Vol. 107; no. 1; pp. 169 - 182
• Main Authors: Hernández, Alfredo I., Le Rolle, Virginie, Ojeda, David, Baconnier, Pierre, Fontecave-Jallon, Julie, Guillaud, François, Grosse, Thibault, Moss, Robert G., Hannaert, Patrick, Thomas, S. Randall
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2011; Elsevier
• Subjects: Bioengineering; Blood Circulation - physiology; blood pressure; Blood Pressure - physiology; Body Fluids - physiology; Cardiac function; Cardiovascular physiology; Computer Science; Endocrine System - physiology; Engineering Sciences; heart; Heart - physiology; Heterogeneous model coupling; homeostasis; Homeostasis - physiology; Humans; Kidney - physiology; Life Sciences; Model interactions; Modeling and Simulation; Models, Biological; Renin-Angiotensin System - physiology; Renin–angiotensin system; Signal and Image Processing; Systems Integration; Renin–angiotensin system; Heterogeneous model coupling; Model interactions; Cardiac function; Cardiovascular physiology; Renin-angiotensin system
• ISSN: 0079-6107; 1873-1732; 1873-1732
• DOI: 10.1016/j.pbiomolbio.2011.06.008

This paper presents a contribution to the definition of the interfaces required to perform heterogeneous model integration in the context of integrative physiology. A formalization of the model integration problem is proposed and a coupling method is presented. The extension of the classic Guyton model, a multi-organ, integrated systems model of blood pressure regulation, is used as an example of the application of the proposed method. To this end, the Guyton model has been restructured, extensive sensitivity analyses have been performed, and appropriate transformations have been applied to replace a subset of its constituting modules by integrating a pulsatile heart and an updated representation of the renin–angiotensin system. Simulation results of the extended integrated model are presented and the impacts of their integration within the original model are evaluated.